Gene/Proteome Database (LMPD)

LMPD ID
LMP013147
Gene ID
296757
Species
Rattus norvegicus (Rat)
Gene Name
N-acyl phosphatidylethanolamine phospholipase D
Gene Symbol
Napepld
Synonyms
NAPE-PLD;
Alternate Names
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D;
Chromosome
4
Map Location
4q11
EC Number
3.1.4.54;
Summary
an atypical phospholipase D that catalyzes the conversion of N-acyl-phosphatidylethanolamines to anandamide and other N-acylethanolamines but has no activity with phosphatidylcholine or phosphatidylethanolamine [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Napepld

Proteins

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Refseq ID NP_955413
Protein GI 40786461
UniProt ID Q769K2
mRNA ID NM_199381
Length 396
MDENENSQSPAPSHQYPKETLRKRQNSVQNSGGSESSRLSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNVSIPNVLRWLIMEKDHSSVPGSKEELDKELPVLKPYFISDPEEAGVREAGLRVTWLGHATLMVEMDELILLTDPMFSSRASPSQYMGPKRFRRPPCTISELPPIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDVQAKRSVAIHWGTFALANEHYLEPPVKLNEALERYGLKSEDFFILKHGESRYLNTDDKAFEET

Gene Information

Entrez Gene ID
296757
Gene Name
N-acyl phosphatidylethanolamine phospholipase D
Gene Symbol
Napepld
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0070290 IEA:InterPro F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0004620 IMP:RGD F phospholipase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0009395 IEA:UniProtKB-KW P phospholipid catabolic process
GO:0006644 TAS:RGD P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04723 Retrograde endocannabinoid signaling
rno04723 Retrograde endocannabinoid signaling

REACTOME Pathway Links

REACTOME Pathway ID Description
5954581 Biosynthesis of A2E, implicated in retinal degradation
5953253 Disease
5953382 Diseases associated with visual transduction
5954579 Retinoid cycle disease events
5953381 Signal Transduction
5953384 The canonical retinoid cycle in rods (twilight vision)
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR001279 Beta-lactamase-like
IPR024884 N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D

UniProt Annotations

Entry Information

Gene Name
N-acyl phosphatidylethanolamine phospholipase D
Protein Entry
NAPEP_RAT
UniProt ID
Q769K2
Species
Rat

Comments

Comment Type Description
Catalytic Activity An N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 1 or 2 zinc ions per subunit. ;
Enzyme Regulation Activity is stimulated by divalent cations
Function Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors. {ECO:0000269|PubMed:14634025, ECO:0000269|PubMed:16527816}.
Similarity Belongs to the NAPE-PLD family
Subcellular Location Membrane .
Subunit Monomer. {ECO:0000269|PubMed:14634025, ECO:0000269|PubMed:16527816}.

Identical and Related Proteins

Unique RefSeq proteins for LMP013147 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
40786461 RefSeq NP_955413 396 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Identical Sequences to LMP013147 proteins

Reference Database Accession Length Protein Name
GI:40786461 EMBL CBX86082.1 396 unnamed protein product [Rattus norvegicus]
GI:40786461 GenBank EDL99421.1 396 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [Rattus norvegicus]
GI:40786461 RefSeq XP_006235973.1 396 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [Rattus norvegicus]
GI:40786461 RefSeq XP_008760861.1 396 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [Rattus norvegicus]

Related Sequences to LMP013147 proteins

Reference Database Accession Length Protein Name
GI:40786461 DBBJ BAD02398.1 396 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [Rattus norvegicus]
GI:40786461 EMBL CBX86082.1 396 unnamed protein product [Rattus norvegicus]
GI:40786461 RefSeq XP_008760861.1 396 PREDICTED: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [Rattus norvegicus]
GI:40786461 SwissProt Q769K2.1 396 RecName: Full=N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Short=N-acyl phosphatidylethanolamine phospholipase D; Short=NAPE-PLD; Short=NAPE-hydrolyzing phospholipase D [Rattus norvegicus]