Gene/Proteome Database (LMPD)

LMPD ID
LMP013158
Gene ID
298399
Species
Rattus norvegicus (Rat)
Gene Name
glucosidase beta 2
Gene Symbol
Gba2
Alternate Names
non-lysosomal glucosylceramidase; NLGase; beta-glucosidase 2; glucosylceramidase 2; beta-glucocerebrosidase 2; bile acid beta-glucosidase;
Chromosome
5
Map Location
5q22
EC Number
3.2.1.45

Proteins

non-lysosomal glucosylceramidase
Refseq ID NP_001013109
Protein GI 189217893
UniProt ID D4A6U0
mRNA ID NM_001013091
Length 904
MVTCVPASEQIGCAERDSQIYSEDTGGTEAVRVTDCRSPEDSGPQNEPGYCNSEDSGQLMASYEGKARGYQVPPFGWRICLAHEFAEKRKPFQANNVSLSNLVKHFGMGLRYLKWWYRKTQVEKKTPFIDMFNSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQFIVCLRRDGRTVYQQVLSLELPSVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDETLDVSIMFSMRNGLGGEDDAAGGLWNEPFRLEQDGTTVQGLLLHHPTPPNPYTMAVAARHTADTTVTYTTAFDPDSTGQQVWQDLLQDGQLDSPAGQSTPTQRGEGVAGAVCASSKLLPRGRCCLEFSLAWDMPRIMFGAKGQVHYRRYTRFFGSDGDVAPALSHYALCQYAGWENSISAWQNPVLDDRSLPAWYKSALFNELYFLADGGTVWLEVPEDSLPEELGGSMYQLRPILQDYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATFKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQGFLKDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAVLCGAQDVQDKFSSILCRGREAYERLLWNGRYYNYDSSSQPQSRSVMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALKTIFELNVQAFAGGAMGAVNGMQPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKNSSRPAVTQGTAPSTA

Gene Information

Entrez Gene ID
298399
Gene Name
glucosidase beta 2
Gene Symbol
Gba2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:UniProtKB-SubCell C endoplasmic reticulum membrane
GO:0000139 IEA:UniProtKB-SubCell C Golgi membrane
GO:0016021 IEA:InterPro C integral component of membrane
GO:0004348 IEA:UniProtKB-EC F glucosylceramidase activity
GO:0006680 IEA:InterPro P glucosylceramide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00511 Other glycan degradation
rno00511 Other glycan degradation
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954485 Glycosphingolipid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR014551 Beta-glucosidase, GBA2 type
IPR024462 Beta-glucosidase, GBA2 type, N-terminal
IPR006775 Glucosylceramidase
IPR008928 Six-hairpin glycosidase-like

UniProt Annotations

Entry Information

Gene Name
glucosidase beta 2
Protein Entry
D4A6U0_RAT
UniProt ID
D4A6U0
Species
Rat

Comments

Comment Type Description
Catalytic Activity D-glucosyl-N-acylsphingosine + H(2)O = D- glucose + N-acylsphingosine
Function Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide
Similarity Belongs to the non-lysosomal glucosylceramidase family
Subcellular Location Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Note=Not localized to lipid rafts

Identical and Related Proteins

Unique RefSeq proteins for LMP013158 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189217893 RefSeq NP_001013109 904 non-lysosomal glucosylceramidase

Identical Sequences to LMP013158 proteins

Reference Database Accession Length Protein Name
GI:189217893 GenBank EDL98757.1 904 glucosidase beta 2 [Rattus norvegicus]

Related Sequences to LMP013158 proteins

Reference Database Accession Length Protein Name
GI:189217893 GenBank AAH56935.1 918 Glucosidase beta 2 [Mus musculus]
GI:189217893 GenBank EDL98757.1 904 glucosidase beta 2 [Rattus norvegicus]
GI:189217893 RefSeq NP_766280.2 918 non-lysosomal glucosylceramidase [Mus musculus]
GI:189217893 SwissProt Q5M868.2 912 RecName: Full=Non-lysosomal glucosylceramidase; Short=NLGase; AltName: Full=Beta-glucocerebrosidase 2; Short=Beta-glucosidase 2; AltName: Full=Glucosylceramidase 2 [Rattus norvegicus]