Gene/Proteome Database (LMPD)

LMPD ID
LMP013163
Gene ID
298596
Species
Rattus norvegicus (Rat)
Gene Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Symbol
Sdhb
Alternate Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; ip; iron-sulfur subunit of complex II;
Chromosome
5
Map Location
5q36
EC Number
1.3.5.1

Proteins

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
Refseq ID NP_001094009
Protein GI 209915614
UniProt ID P21913
mRNA ID NM_001100539
Length 282
MAAVVGVSLKRGFSATALGRVGLQFQACREAQTAAAAAPRIKTFAIYRWDPDKAGDKPRMQTYKVDLNKCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLGKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDEFTEERLAKLQDPFSLYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA
transit_peptide: 1..30 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P21913.2) calculated_mol_wt: 3124 peptide sequence: MAAVVGVSLKRGFSATALGRVGLQFQACRE mat_peptide: 31..282 product: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P21913.2) calculated_mol_wt: 28724 peptide sequence: AQTAAAAAPRIKTFAIYRWDPDKAGDKPRMQTYKVDLNKCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLGKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDEFTEERLAKLQDPFSLYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA

Gene Information

Entrez Gene ID
298596
Gene Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Symbol
Sdhb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005743 ISS:UniProtKB C mitochondrial inner membrane
GO:0005749 ISS:UniProtKB C mitochondrial respiratory chain complex II
GO:0051537 ISS:UniProtKB F 2 iron, 2 sulfur cluster binding
GO:0051538 ISS:UniProtKB F 3 iron, 4 sulfur cluster binding
GO:0051539 ISS:UniProtKB F 4 iron, 4 sulfur cluster binding
GO:0009055 IEA:InterPro F electron carrier activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0008177 IMP:RGD F succinate dehydrogenase (ubiquinone) activity
GO:0048039 ISS:UniProtKB F ubiquinone binding
GO:0022904 IMP:RGD P respiratory electron transport chain
GO:0006105 IMP:RGD P succinate metabolic process
GO:0006099 IEA:UniProtKB-UniPathway P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
ko05010 Alzheimer's disease
rno05010 Alzheimer's disease
ko01200 Carbon metabolism
rno01200 Carbon metabolism
ko00020 Citrate cycle (TCA cycle)
rno00020 Citrate cycle (TCA cycle)
M00009 Citrate cycle (TCA cycle, Krebs cycle)
M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
ko05016 Huntington's disease
rno05016 Huntington's disease
rno01100 Metabolic pathways
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko00190 Oxidative phosphorylation
rno00190 Oxidative phosphorylation
rno05012 Parkinson's disease
M00148 Succinate dehydrogenase (ubiquinone)

REACTOME Pathway Links

REACTOME Pathway ID Description
5953285 Citric acid cycle (TCA cycle)
5953250 Metabolism
5953269 Pyruvate metabolism and Citric Acid (TCA) cycle
5953747 Respiratory electron transport
5953748 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
IPR001041 2Fe-2S ferredoxin-type domain
IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
IPR009051 Alpha-helical ferredoxin
IPR012675 Beta-grasp domain
IPR025192 Succinate dehydogenase/fumarate reductase N-terminal
IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein

UniProt Annotations

Entry Information

Gene Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Protein Entry
SDHB_RAT
UniProt ID
P21913
Species
Rat

Comments

Comment Type Description
Catalytic Activity Succinate + a quinone = fumarate + a quinol.
Cofactor Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence= ; Note=Binds 1 [2Fe-2S] cluster. ;
Cofactor Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence= ; Note=Binds 1 [3Fe-4S] cluster. ;
Cofactor Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence= ; Note=Binds 1 [4Fe-4S] cluster. ;
Function Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Similarity Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family
Similarity Contains 1 2Fe-2S ferredoxin-type domain
Similarity Contains 1 4Fe-4S ferredoxin-type domain
Subcellular Location Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
Subunit Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD

Identical and Related Proteins

Unique RefSeq proteins for LMP013163 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
209915614 RefSeq NP_001094009 282 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

Identical Sequences to LMP013163 proteins

Reference Database Accession Length Protein Name
GI:209915614 GenBank EDL80954.1 282 succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (predicted), isoform CRA_d [Rattus norvegicus]
GI:209915614 GenBank AAI58621.1 282 Sdhb protein [Rattus norvegicus]
GI:209915614 SwissProt P21913.2 282 RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; AltName: Full=Iron-sulfur subunit of complex II; Short=Ip; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013163 proteins

Reference Database Accession Length Protein Name
GI:209915614 GenBank EDL80954.1 282 succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (predicted), isoform CRA_d [Rattus norvegicus]
GI:209915614 GenBank AAI58621.1 282 Sdhb protein [Rattus norvegicus]
GI:209915614 RefSeq XP_005352976.1 282 PREDICTED: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [Microtus ochrogaster]
GI:209915614 SwissProt P21913.2 282 RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; AltName: Full=Iron-sulfur subunit of complex II; Short=Ip; Flags: Precursor [Rattus norvegicus]