Gene/Proteome Database (LMPD)

LMPD ID
LMP013170
Gene ID
299194
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin reductase 2
Gene Symbol
Ptgr2
Synonyms
Zadh1;
Alternate Names
prostaglandin reductase 2; PRG-2 {ECO:0000250|UniProtKB:Q8VDQ1}; ptgr2 {ECO:0000250|UniProtKB:Q8VDQ1}; zinc binding alcohol dehydrogenase, domain containing 1; prostaglandin reductase 2 {ECO:0000250|UniProtKB:Q8VDQ1}; zinc-binding alcohol dehydrogenase domain-containing protein 1; 15-oxoprostaglandin 13-reductase {ECO:0000250|UniProtKB:Q8VDQ1};
Chromosome
6
Map Location
6q31
EC Number
1.3.1.48

Proteins

prostaglandin reductase 2
Refseq ID NP_001015009
Protein GI 62543513
UniProt ID Q5BK81
mRNA ID NM_001015009
Length 281
MIIQRVVLDSRPGKNGNPVAENFRVEEVSLPDTINEGQVRVRTLYLSVDPYMRCKMNEETGADYLAPWQLAQVADGGGLGVIEESKHQKLAKGDFVTSFYWPWQTKAILDGNGLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGVQEKGHVSAGSNQTMVVSGAAGACGSLAGQIGHLLGCSRVVGICGTHEKCLFLTSELGFDAAVNYKTGNVAEQLREACPDGVDVYFDNVGGDISNAVISQIKETVANGLENMGVAFQSMMTGGNIGKQIVRISEDSSP

Gene Information

Entrez Gene ID
299194
Gene Name
prostaglandin reductase 2
Gene Symbol
Ptgr2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0036132 IEA:UniProtKB-EC F 13-prostaglandin reductase activity
GO:0047522 ISS:UniProtKB F 15-oxoprostaglandin 13-oxidase activity
GO:0006693 ISS:UniProtKB P prostaglandin metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR013149 Alcohol dehydrogenase, C-terminal
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
prostaglandin reductase 2
Protein Entry
PTGR2_RAT
UniProt ID
Q5BK81
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q5BK81-1; Sequence=Displayed; Note=Gene prediction based on similarity to mouse ortholog. ; Name=2 ; IsoId=Q5BK81-2; Sequence=VSP_052852; Note=No experimental confirmation available. ;
Catalytic Activity 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13- dienoate + NAD(P)H
Function Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)
Similarity Belongs to the NADP-dependent oxidoreductase L4BD family
Subcellular Location Cytoplasm .
Subunit Monomer

Identical and Related Proteins

Unique RefSeq proteins for LMP013170 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62543513 RefSeq NP_001015009 281 prostaglandin reductase 2

Identical Sequences to LMP013170 proteins

Reference Database Accession Length Protein Name
GI:62543513 GenBank AAH91173.1 281 Prostaglandin reductase 2 [Rattus norvegicus]

Related Sequences to LMP013170 proteins

Reference Database Accession Length Protein Name
GI:62543513 GenBank AAH91173.1 281 Prostaglandin reductase 2 [Rattus norvegicus]
GI:62543513 GenBank EDL81483.1 351 zinc binding alcohol dehydrogenase, domain containing 1, isoform CRA_b [Rattus norvegicus]
GI:62543513 RefSeq XP_006240388.1 351 PREDICTED: prostaglandin reductase 2 isoform X1 [Rattus norvegicus]
GI:62543513 RefSeq XP_006240389.1 351 PREDICTED: prostaglandin reductase 2 isoform X1 [Rattus norvegicus]