Gene/Proteome Database (LMPD)

LMPD ID
LMP013175
Gene ID
299270
Species
Rattus norvegicus (Rat)
Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Gene Symbol
Serpina6
Synonyms
Cbg;
Alternate Names
corticosteroid-binding globulin; serpin A6; transcortin; corticosteroid binding globulin; serpin peptidase inhibitor, clade A, member 6; serine (or cysteine) peptidase inhibitor, clade A, member 6; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6;
Chromosome
6
Map Location
6q32

Proteins

corticosteroid-binding globulin precursor
Refseq ID NP_001009663
Protein GI 57527135
UniProt ID P31211
mRNA ID NM_001009663
Length 396
MSLALYTCLLWLCTSGLWTAQASTNESSNSHRGLAPTNVDFAFNLYQRLVALNPDKNTLISPVSISMALAMVSLGSAQTQSLQSLGFNLTETSEAEIHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALAIDFEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLRGIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQLIQMDYVGNGTAFFILPDQGQMDTVIAALSRDTIDRWGKLMTPRQVNLYIPKFSISDTYDLKDMLEDLNIKDLLTNQSDFSGNTKDVPLTLTMVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLDIKFNKPFILLLFDKFTWSSLMMSQVVNPA
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2446 peptide sequence: MSLALYTCLLWLCTSGLWTAQA mat_peptide: 23..396 product: Corticosteroid-binding globulin experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P31211.2) calculated_mol_wt: 42243 peptide sequence: STNESSNSHRGLAPTNVDFAFNLYQRLVALNPDKNTLISPVSISMALAMVSLGSAQTQSLQSLGFNLTETSEAEIHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALAIDFEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLRGIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQLIQMDYVGNGTAFFILPDQGQMDTVIAALSRDTIDRWGKLMTPRQVNLYIPKFSISDTYDLKDMLEDLNIKDLLTNQSDFSGNTKDVPLTLTMVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLDIKFNKPFILLLFDKFTWSSLMMSQVVNPA

Gene Information

Entrez Gene ID
299270
Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Gene Symbol
Serpina6
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IBA:RefGenome C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0004867 IBA:RefGenome F serine-type endopeptidase inhibitor activity
GO:0005496 ISS:UniProtKB F steroid binding
GO:0008211 IEA:Ensembl P glucocorticoid metabolic process
GO:0010951 IBA:RefGenome P negative regulation of endopeptidase activity
GO:0030162 IBA:RefGenome P regulation of proteolysis
GO:0006810 IEA:UniProtKB-KW P transport

Domain Information

InterPro Annotations

Accession Description
IPR023795 Serpin, conserved site
IPR023796 Serpin domain
IPR000215 Serpin family

UniProt Annotations

Entry Information

Gene Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Protein Entry
CBG_RAT
UniProt ID
P31211
Species
Rat

Comments

Comment Type Description
Domain Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids (By similarity)
Function Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species
Similarity Belongs to the serpin family
Subcellular Location Secreted.
Tissue Specificity Expressed by the liver; secreted in plasma

Identical and Related Proteins

Unique RefSeq proteins for LMP013175 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
57527135 RefSeq NP_001009663 396 corticosteroid-binding globulin precursor

Identical Sequences to LMP013175 proteins

Reference Database Accession Length Protein Name
GI:57527135 GenBank AAH88300.1 396 Serine (or cysteine) peptidase inhibitor, clade A, member 6 [Rattus norvegicus]
GI:57527135 GenBank EDL81783.1 396 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped) [Rattus norvegicus]
GI:57527135 SwissProt P31211.2 396 RecName: Full=Corticosteroid-binding globulin; Short=CBG; AltName: Full=Serpin A6; AltName: Full=Transcortin; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013175 proteins

Reference Database Accession Length Protein Name
GI:57527135 GenBank AAH88300.1 396 Serine (or cysteine) peptidase inhibitor, clade A, member 6 [Rattus norvegicus]
GI:57527135 GenBank EDL81783.1 396 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (mapped) [Rattus norvegicus]
GI:57527135 PDB 2V95 371 Chain A, Struture Of Corticosteroid-Binding Globulin In Complex With Cortisol
GI:57527135 SwissProt P31211.2 396 RecName: Full=Corticosteroid-binding globulin; Short=CBG; AltName: Full=Serpin A6; AltName: Full=Transcortin; Flags: Precursor [Rattus norvegicus]