Gene/Proteome Database (LMPD)

LMPD ID
LMP013181
Gene ID
299809
Species
Rattus norvegicus (Rat)
Gene Name
chaperonin containing TCP1, subunit 2 (beta)
Gene Symbol
Cct2
Alternate Names
T-complex protein 1 subunit beta; CCT-beta; TCP-1-beta;
Chromosome
7
Map Location
7q22

Proteins

T-complex protein 1 subunit beta
Refseq ID NP_001005905
Protein GI 54400730
UniProt ID Q5XIM9
mRNA ID NM_001005905
Length 535
MASLSLAPVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDPRTVYGGGCSEMLMAHAVTMLASRTPGKEAVAMESFAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGRITAGLDMKEGSIGDMAVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC

Gene Information

Entrez Gene ID
299809
Gene Name
chaperonin containing TCP1, subunit 2 (beta)
Gene Symbol
Cct2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0044297 IEA:Ensembl C cell body
GO:0005832 IEA:Ensembl C chaperonin-containing T-complex
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005874 IEA:Ensembl C microtubule
GO:0002199 IEA:Ensembl C zona pellucida receptor complex
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0007339 IEA:Ensembl P binding of sperm to zona pellucida
GO:0051131 IEA:Ensembl P chaperone-mediated protein complex assembly
GO:0006457 IEA:InterPro P protein folding

REACTOME Pathway Links

REACTOME Pathway ID Description
5954190 Association of TriC/CCT with target proteins during biosynthesis
5954184 Chaperonin-mediated protein folding
5954183 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
5954189 Folding of actin by CCT/TriC
5954182 Formation of tubulin folding intermediates by CCT/TriC
5953345 Metabolism of proteins
5954187 Prefoldin mediated transfer of substrate to CCT/TriC
5954185 Protein folding

Domain Information

InterPro Annotations

Accession Description
IPR012716 Chap_CCT_beta
IPR017998 Chaperone_TCP-1
IPR002423 Chaperonin Cpn60/TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR027413 GROEL-like_equatorial
IPR027409 GroEL-like apical domain
IPR027410 TCP-1-like chaperonin intermediate domain

UniProt Annotations

Entry Information

Gene Name
chaperonin containing TCP1, subunit 2 (beta)
Protein Entry
TCPB_RAT
UniProt ID
Q5XIM9
Species
Rat

Comments

Comment Type Description
Function Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity)
Similarity Belongs to the TCP-1 chaperonin family
Subcellular Location Cytoplasm .
Subunit Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013181 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
54400730 RefSeq NP_001005905 535 T-complex protein 1 subunit beta

Identical Sequences to LMP013181 proteins

Reference Database Accession Length Protein Name
GI:54400730 GenBank AAH83650.1 535 Chaperonin containing TCP1, subunit 2 (beta) [Rattus norvegicus]
GI:54400730 GenBank EDM16634.1 535 chaperonin containing TCP1, subunit 2 (beta) [Rattus norvegicus]
GI:54400730 SwissProt Q5XIM9.3 535 RecName: Full=T-complex protein 1 subunit beta; Short=TCP-1-beta; AltName: Full=CCT-beta [Rattus norvegicus]

Related Sequences to LMP013181 proteins

Reference Database Accession Length Protein Name
GI:54400730 GenBank AAH83650.1 535 Chaperonin containing TCP1, subunit 2 (beta) [Rattus norvegicus]
GI:54400730 GenBank EDM16634.1 535 chaperonin containing TCP1, subunit 2 (beta) [Rattus norvegicus]
GI:54400730 RefSeq XP_004845117.1 535 PREDICTED: T-complex protein 1 subunit beta isoform X2 [Heterocephalus glaber]
GI:54400730 SwissProt Q5XIM9.3 535 RecName: Full=T-complex protein 1 subunit beta; Short=TCP-1-beta; AltName: Full=CCT-beta [Rattus norvegicus]