Gene/Proteome Database (LMPD)
LMPD ID
LMP013185
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
sterol regulatory element binding transcription factor 2
Gene Symbol
Synonyms
SREBP2; SREBP-2; Srebf2_retired;
Alternate Names
sterol regulatory element-binding protein 2; srebf2 {ECO:0000312|EMBL:AAI01903.1}; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; sterol regulatory element-binding transcription factor 2;
Chromosome
7
Map Location
7q34
Summary
transcription factor; may be involved in spermatogenesis [RGD, Feb 2006]
Orthologs
Proteins
| sterol regulatory element-binding protein 2 | |
|---|---|
| Refseq ID | NP_001028866 |
| Protein GI | 76096332 |
| UniProt ID | Q3T1I5 |
| mRNA ID | NM_001033694 |
| Length | 1133 |
| MDENSELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFSDLFSEQLCSSFPGGGGGSGSGGTSNNSSGRGTSGGAADPAVQRSFSQVPLSTFSPSSTSPQAPALQVKVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVATPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGAILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNPDQHPYSGSGRNVLSLESGSGGWFDWMMPTLLLWLLNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSIKSAAKDSLYCAQRNPADPIAQVHQAFCKHLLERAVEALVKPQAKKKAGDREEESCEFSSALEFLKLLHSFVDSVGFVASPFSSSSVLRSALGPDVVCRWWTSAITVAISWLQGDDAAVRSHFTEVERVPKALEVTESPLVKAVFYACRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVVQLLTCDLLLSLRTTLWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS | |
Gene Information
Entrez Gene ID
Gene Name
sterol regulatory element binding transcription factor 2
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:RGD | C | cytoplasm |
| GO:0031410 | IEA:UniProtKB-KW | C | cytoplasmic vesicle |
| GO:0030425 | IDA:RGD | C | dendrite |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0043231 | IDA:RGD | C | intracellular membrane-bounded organelle |
| GO:0005634 | IDA:RGD | C | nucleus |
| GO:0003682 | IDA:RGD | F | chromatin binding |
| GO:0043565 | IDA:MGI | F | sequence-specific DNA binding |
| GO:0007568 | IEP:RGD | P | aging |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0008610 | TAS:RGD | P | lipid biosynthetic process |
| GO:0045893 | IMP:RGD | P | positive regulation of transcription, DNA-templated |
| GO:0045944 | IDA:MGI | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0042493 | IEP:RGD | P | response to drug |
| GO:0009725 | IMP:RGD | P | response to hormone |
| GO:0010288 | IEP:RGD | P | response to lead ion |
| GO:0033993 | IEP:RGD | P | response to lipid |
| GO:0007283 | IEP:RGD | P | spermatogenesis |
| GO:0006351 | IEA:UniProtKB-KW | P | transcription, DNA-templated |
Domain Information
UniProt Annotations
Entry Information
Gene Name
sterol regulatory element binding transcription factor 2
Protein Entry
SRBP2_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Function | Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity) |
| Ptm | At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7 (By similarity) |
| Ptm | Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression |
| Similarity | Belongs to the SREBP family |
| Similarity | Contains 1 bHLH (basic helix-loop-helix) domain |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein . Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols |
| Subcellular Location | Processed sterol regulatory element-binding protein 2: Nucleus {ECO:0000250|UniProtKB:Q12772, ECO:0000255|PROSITE-ProRule:PRU00981}. |
| Subunit | Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts (via C-terminal domain) with RNF139 (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP013185 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 76096332 | RefSeq | NP_001028866 | 1133 | sterol regulatory element-binding protein 2 |
Identical Sequences to LMP013185 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:76096332 | GenBank | AAI01903.1 | 1133 | Sterol regulatory element binding transcription factor 2 [Rattus norvegicus] |
| GI:76096332 | SwissProt | Q3T1I5.1 | 1133 | RecName: Full=Sterol regulatory element-binding protein 2; Short=SREBP-2; AltName: Full=Sterol regulatory element-binding transcription factor 2; Contains: RecName: Full=Processed sterol regulatory element-binding protein 2 [Rattus norvegicus] |
Related Sequences to LMP013185 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:76096332 | GenBank | AAI01903.1 | 1133 | Sterol regulatory element binding transcription factor 2 [Rattus norvegicus] |
| GI:76096332 | GenBank | AAI67259.1 | 1130 | Sterol regulatory element binding factor 2 [synthetic construct] |
| GI:76096332 | RefSeq | XP_006242141.1 | 1103 | PREDICTED: sterol regulatory element-binding protein 2 isoform X1 [Rattus norvegicus] |
| GI:76096332 | SwissProt | Q3T1I5.1 | 1133 | RecName: Full=Sterol regulatory element-binding protein 2; Short=SREBP-2; AltName: Full=Sterol regulatory element-binding transcription factor 2; Contains: RecName: Full=Processed sterol regulatory element-binding protein 2 [Rattus norvegicus] |