Gene/Proteome Database (LMPD)
Proteins
| low-density lipoprotein receptor precursor | |
|---|---|
| Refseq ID | NP_786938 |
| Protein GI | 28461161 |
| UniProt ID | P35952 |
| mRNA ID | NM_175762 |
| Length | 879 |
| MSTADLMLRWAIALLLAAAGVAAEDSCGKNEFQCRDGKCIVSKWVCDGSRECPDGSDESPETCMSVTCRSGEFSCGGRVSRCIPDSWRCDGRTDCENGSDELDCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDGSDEAHCAATTCGPAHFRCNSSSCIPSLWACDGDRDCDDGSDEWPQNCGAEDTAAEVVSSPCSSLEFHCGSSECIHRSWVCDGAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCINVTQCDGPNKFKCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHICKDLKIGYECLCPSGFRLVDGHQCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFHMDPHTRVCKAVGSIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQRKIYSAVMDQGTSLSYDAIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGGRKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKNLMSPEDIVLFHNVTQPRGVNWCEATVLPNGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDTVPTTQGTSTIGPVVTTSAAVSLKRKEDPSATRHKEDPSATRHNEDPSATSTSRQPGDTPELSTVESVTVSSQVQGDMAGRGDEVQRHGVGFLSIFLPIALVALLVFGAILLWRNWRLRNINSINFDNPVYQKTTEDEIHICRSQDGYTYPSRQMVSLEDDVA | |
| sig_peptide: 1..21 note: signal peptide (-21 to -1) calculated_mol_wt: 2188 peptide sequence: MSTADLMLRWAIALLLAAAGV mat_peptide: 22..879 product: low-density lipoprotein receptor calculated_mol_wt: 94453 peptide sequence: AAEDSCGKNEFQCRDGKCIVSKWVCDGSRECPDGSDESPETCMSVTCRSGEFSCGGRVSRCIPDSWRCDGRTDCENGSDELDCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDGSDEAHCAATTCGPAHFRCNSSSCIPSLWACDGDRDCDDGSDEWPQNCGAEDTAAEVVSSPCSSLEFHCGSSECIHRSWVCDGAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCINVTQCDGPNKFKCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHICKDLKIGYECLCPSGFRLVDGHQCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFHMDPHTRVCKAVGSIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQRKIYSAVMDQGTSLSYDAIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGGRKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKNLMSPEDIVLFHNVTQPRGVNWCEATVLPNGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDTVPTTQGTSTIGPVVTTSAAVSLKRKEDPSATRHKEDPSATRHNEDPSATSTSRQPGDTPELSTVESVTVSSQVQGDMAGRGDEVQRHGVGFLSIFLPIALVALLVFGAILLWRNWRLRNINSINFDNPVYQKTTEDEIHICRSQDGYTYPSRQMVSLEDDVA | |
Gene Information
Entrez Gene ID
Gene Name
low density lipoprotein receptor
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | ISS:UniProtKB | C | Golgi apparatus |
| GO:0005901 | IDA:RGD | C | caveola |
| GO:0009986 | ISS:UniProtKB | C | cell surface |
| GO:0005905 | IEA:UniProtKB-KW | C | coated pit |
| GO:0005769 | ISS:UniProtKB | C | early endosome |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005770 | ISS:UniProtKB | C | late endosome |
| GO:0034362 | IEA:UniProtKB-KW | C | low-density lipoprotein particle |
| GO:0005764 | ISS:UniProtKB | C | lysosome |
| GO:0005886 | IDA:RGD | C | plasma membrane |
| GO:0055038 | IDA:RGD | C | recycling endosome membrane |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0005041 | IMP:RGD | F | low-density lipoprotein receptor activity |
| GO:0007568 | IEP:RGD | P | aging |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0006897 | IMP:RGD | P | endocytosis |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
| GO:0006898 | IMP:GOC | P | receptor-mediated endocytosis |
| GO:0032355 | IEP:RGD | P | response to estradiol |
| GO:0043627 | IEP:RGD | P | response to estrogen |
| GO:0033762 | IEP:RGD | P | response to glucagon |
| GO:0009725 | IEP:RGD | P | response to hormone |
| GO:0001666 | IEP:RGD | P | response to hypoxia |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR026823 | Complement Clr-like EGF domain |
| IPR001881 | EGF-like calcium-binding domain |
| IPR018097 | EGF-like calcium-binding, conserved site |
| IPR013032 | EGF-like, conserved site |
| IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| IPR000742 | Epidermal growth factor-like domain |
| IPR009030 | Insulin-like growth factor binding protein, N-terminal |
| IPR000033 | LDLR class B repeat |
| IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
| IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| IPR011042 | Six-bladed beta-propeller, TolB-like |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | The NPXY motif mediates the interaction with the clathrin adaptor DAB2 involved in receptor internalization |
| Function | Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. |
| Ptm | Ubiquitinated by MYLIP leading to degradation |
| Similarity | Belongs to the LDLR family |
| Similarity | Contains 3 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}. |
| Similarity | Contains 6 LDL-receptor class B repeats |
| Similarity | Contains 7 LDL-receptor class A domains |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit ; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus . Early endosome {ECO:0000250}. Late endosome . Cell surface {ECO:0000250}. Lysosome . Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9 (By similarity) |
| Subunit | Interacts with LDLRAP1, ARRB1, SNX17. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts with the full length immature form of PCSK9 (via C-terminus) (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP013190 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 28461161 | RefSeq | NP_786938 | 879 | low-density lipoprotein receptor precursor |
Identical Sequences to LMP013190 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:28461161 | EMBL | CAA32001.1 | 879 | unnamed protein product [Rattus norvegicus] |
| GI:28461161 | SwissProt | P35952.1 | 879 | RecName: Full=Low-density lipoprotein receptor; Short=LDL receptor; Flags: Precursor [Rattus norvegicus] |
Related Sequences to LMP013190 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:28461161 | EMBL | CAA32001.1 | 879 | unnamed protein product [Rattus norvegicus] |
| GI:28461161 | GenBank | AAH19207.1 | 862 | Low density lipoprotein receptor [Mus musculus] |
| GI:28461161 | GenBank | EDL78274.1 | 879 | low density lipoprotein receptor, isoform CRA_a [Rattus norvegicus] |
| GI:28461161 | SwissProt | P35952.1 | 879 | RecName: Full=Low-density lipoprotein receptor; Short=LDL receptor; Flags: Precursor [Rattus norvegicus] |