Gene/Proteome Database (LMPD)

LMPD ID
LMP013192
Gene ID
300652
Species
Rattus norvegicus (Rat)
Gene Name
sortilin-related receptor, LDLR class A repeats-containing
Gene Symbol
Sorl1
Synonyms
Lr11; RGD619914;
Alternate Names
sortilin-related receptor;
Chromosome
8
Map Location
8q22
Summary
may play a role in lipoprotein metabolism; increased expression occurs in response to balloon injury endothelial denudation in an experimental model for atherogenesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Sorl1

Proteins

sortilin-related receptor precursor
Refseq ID NP_445971
Protein GI 281599339
UniProt ID F1M135
mRNA ID NM_053519
Length 2215
MATRSSRRESRLPFLFTLVALLPPGALGGGWTQRLHGGGAPLPQDRGFFVVQGDPHELRLGTHGDAWGASPAARKPLRTRRSAALQPQPIQVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALTRPKSSDVYVSYDYGKSFNKISEKLNFGVGNSSEAVISQFYHSPADNKRYIFVDAYARYLWITFDFGSTIHGFSIPFRAADLLLHSKASNLLLGFDSSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNTIYIERHEPFGFSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYLFATKVVHLPGSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIADASEDQVFVCVSHSNNSTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMSEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDISLEVCVPDPEFSGKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAMRKSIYRYDLASGATEQLPLSGLRAAVALDFDYEHNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYRLVSEDVKWPNGISVDGHWIYWTDAYLDCIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSRSQVETLASQLTGLMDMKIFYKGKNAGSNACIPQPCSLLCLPKANNSKSCRCPEGVASSVLPSGYLMCDCPQGYERKNNTCVKEENTCLRNQYHCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDADTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCHNGHCIPQRWACDGDADCQDGSDEDPISCEKKCNGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDATFAGCSQDPEFHKECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFHCENGRCIPNRWKCDRENDCGDWSDEKDCGDSHIFPSPTPGPSTCLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEACPSLANSTAASTPTQLGQCDRFEFECRQPKKCIPNWKRCDGHQDCQDGQDEANCPTHSTLTCMSREFKCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWIADFSGDVTLTWTRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQVHCLSKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSEEEGVILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTTKGKVIQAPNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFWSFDAHKQEKKTLNFRGGSSLSHKVSNLTAHTSYEVSAWAKTDLGDSPLAFEHILTRGISPPAPSLKAKAINQTAVECIWTGPKNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVLIPYQGPSSDYVVVKMIPDSRLPPRHLHAVQIGKTSAVIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKQFNETRGYEIHMFDSAVNLTAYLGNTTDNFFKVSNLKMGHNYTFTVQARCLFGSQICGEPAVLLYDELSSGGDATVVQTARSTDVAAVVVPILFLILLSLGVGFAVLYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA
sig_peptide: 1..28 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3058 peptide sequence: MATRSSRRESRLPFLFTLVALLPPGALG

Gene Information

Entrez Gene ID
300652
Gene Name
sortilin-related receptor, LDLR class A repeats-containing
Gene Symbol
Sorl1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005769 IEA:Ensembl C early endosome
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0031985 IEA:Ensembl C Golgi cisterna
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005771 IDA:RGD C multivesicular body
GO:0043025 IDA:RGD C neuronal cell body
GO:0005641 IEA:Ensembl C nuclear envelope lumen
GO:0055037 IEA:Ensembl C recycling endosome
GO:0005802 IEA:Ensembl C trans-Golgi network
GO:0001540 IEA:Ensembl F beta-amyloid binding
GO:0030169 IEA:Ensembl F low-density lipoprotein particle binding
GO:0016477 IMP:RGD P cell migration
GO:0008283 IEP:RGD P cell proliferation
GO:1902960 IEA:Ensembl P negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902430 IEA:Ensembl P negative regulation of beta-amyloid formation
GO:0043407 IEA:Ensembl P negative regulation of MAP kinase activity
GO:1902963 IEA:Ensembl P negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902997 IEA:Ensembl P negative regulation of neurofibrillary tangle assembly
GO:0050768 IEA:Ensembl P negative regulation of neurogenesis
GO:1901215 IEA:Ensembl P negative regulation of neuron death
GO:0032091 IEA:Ensembl P negative regulation of protein binding
GO:0032460 IEA:Ensembl P negative regulation of protein oligomerization
GO:1902948 IEA:Ensembl P negative regulation of tau-protein kinase activity
GO:1902771 IEA:Ensembl P positive regulation of choline O-acetyltransferase activity
GO:1902955 IEA:Ensembl P positive regulation of early endosome to recycling endosome transport
GO:2001137 IEA:Ensembl P positive regulation of endocytic recycling
GO:1902953 IEA:Ensembl P positive regulation of ER to Golgi vesicle-mediated transport
GO:0045732 IEA:Ensembl P positive regulation of protein catabolic process
GO:0070863 IEA:Ensembl P positive regulation of protein exit from endoplasmic reticulum
GO:1902966 IEA:Ensembl P positive regulation of protein localization to early endosome
GO:0006892 IEA:Ensembl P post-Golgi vesicle-mediated transport
GO:0051604 IEA:Ensembl P protein maturation
GO:0045053 IEA:Ensembl P protein retention in Golgi apparatus
GO:0000042 IEA:Ensembl P protein targeting to Golgi
GO:0006622 IEA:Ensembl P protein targeting to lysosome
GO:0014910 IEA:Ensembl P regulation of smooth muscle cell migration

Domain Information

InterPro Annotations

Accession Description
IPR003961 Fibronectin type III
IPR013783 Immunoglobulin-like fold
IPR000033 LDLR class B repeat
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR011042 Six-bladed beta-propeller, TolB-like
IPR006581 VPS10

UniProt Annotations

Entry Information

Gene Name
sortilin-related receptor, LDLR class A repeats-containing
Protein Entry
F1M135_RAT
UniProt ID
F1M135
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP013192 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
281599339 RefSeq NP_445971 2215 sortilin-related receptor precursor

Identical Sequences to LMP013192 proteins

Reference Database Accession Length Protein Name
GI:281599339 GenBank EDL95248.1 2215 rCG58189 [Rattus norvegicus]

Related Sequences to LMP013192 proteins

Reference Database Accession Length Protein Name
GI:281599339 GenBank EDL95248.1 2215 rCG58189 [Rattus norvegicus]
GI:281599339 GenBank AAI72714.1 2215 Sortilin-related receptor, LDLR class A repeats-containing [synthetic construct]
GI:281599339 GenBank AAI56441.1 2215 Sortilin-related receptor, LDLR class A repeats-containing, partial [synthetic construct]
GI:281599339 RefSeq NP_035566.2 2215 sortilin-related receptor precursor [Mus musculus]