Gene/Proteome Database (LMPD)
LMPD ID
LMP013198
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
SREBF chaperone
Gene Symbol
Alternate Names
sterol regulatory element-binding protein cleavage-activating protein; SREBP cleavage activating protein; SREBP cleavage-activating protein; scap {ECO:0000312|EMBL:AAI31853.1};
Chromosome
8
Map Location
8q32
Proteins
| sterol regulatory element-binding protein cleavage-activating protein | |
|---|---|
| Refseq ID | NP_001094436 |
| Protein GI | 155369287 |
| UniProt ID | A2RRU4 |
| mRNA ID | NM_001100966 |
| Length | 1276 |
| MTLTERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPESCLPSAKPVGRPARYERQLAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVLPASHPDPAFSIFPPDAPKLPENQTLPGELPEHAVPAEGVQDSRAPEVTWGPEDEELWRKLSFRHWPTLFNYYNITLAKRYISLLPVIPVTLHLNPREALEGRHPQDGRTAWAPPEPLPAGLWETGPKGPGGTQTHGDITLYKVAALGLAAGIVLVLLLLCLYRVLCPRNYGQPGGGAGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIECLASDGMLLVSCCLAGQVCVWDAQTGDCLTRIPRPGPRRDSCGGGAFEAQENWERLSDGGKASPEEPGDSPPLRRRPRGPPPPSLFGDQPDLTCLIDTNFSVQLPPEPTQPEPRHRAGCGRSRDSGYDFSRLVQRVYQEEGLAAVHMSALRPPSPGPPLPQASQEEGTAPEKGSPPLAWAPSTAGSIWSLELQGSLIVVGRSSGRLEVWDAIEGVLCCSNEEISSGITALVFLDRRIVAARLNGSLDFFSLETHTSLSPLQFRGTPGRGSSPSSPVYSSSNTVACHLTHTVPCAHQKPITALRAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGAICLWDVLTGSRVSHTFAHRGDVTSLTCTTSCVISSGLDDFINIWDRSTGIKLYSIQQDLGCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCNFGSELSLVYVPSVLEKLD | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031410 | IEA:UniProtKB-KW | C | cytoplasmic vesicle |
| GO:0005789 | IEA:Ensembl | C | endoplasmic reticulum membrane |
| GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0043231 | IDA:RGD | C | intracellular membrane-bounded organelle |
| GO:0043234 | IDA:RGD | C | protein complex |
| GO:0032403 | IPI:RGD | F | protein complex binding |
| GO:0007568 | IEP:RGD | P | aging |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0045540 | IEA:Ensembl | P | regulation of cholesterol biosynthetic process |
| GO:0042304 | IEA:Ensembl | P | regulation of fatty acid biosynthetic process |
| GO:0001666 | IEA:Ensembl | P | response to hypoxia |
| GO:0032868 | IEA:Ensembl | P | response to insulin |
| GO:0032933 | IEA:Ensembl | P | SREBP signaling pathway |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signal on SCAP possibly by moving the signal further away from the ER membrane |
| Function | Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity) |
| Similarity | Belongs to the WD repeat SCAP family |
| Similarity | Contains 1 SSD (sterol-sensing) domain |
| Similarity | Contains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}. |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein . Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols |
| Subunit | Membrane region forms a homotetramer. Forms a stable complex with SREBF1/SREBP1 or SREBF2/SREBP2 through its C-terminal cytoplasmic domain. Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at high sterol concentrations. Interacts with the SEC23/SEC24 complex in a SAR1-GTP-dependent manner through an ER export signal in its third cytoplasmic loop. Binds cholesterol through its SSC domain. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts with RNF139; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP013198 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 155369287 | RefSeq | NP_001094436 | 1276 | sterol regulatory element-binding protein cleavage-activating protein |
Identical Sequences to LMP013198 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:155369287 | RefSeq | XP_006243984.1 | 1276 | PREDICTED: sterol regulatory element-binding protein cleavage-activating protein isoform X1 [Rattus norvegicus] |
| GI:155369287 | RefSeq | XP_006243985.1 | 1276 | PREDICTED: sterol regulatory element-binding protein cleavage-activating protein isoform X1 [Rattus norvegicus] |
| GI:155369287 | RefSeq | XP_006243986.1 | 1276 | PREDICTED: sterol regulatory element-binding protein cleavage-activating protein isoform X1 [Rattus norvegicus] |
| GI:155369287 | RefSeq | XP_006243987.1 | 1276 | PREDICTED: sterol regulatory element-binding protein cleavage-activating protein isoform X1 [Rattus norvegicus] |
Related Sequences to LMP013198 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:155369287 | RefSeq | XP_006243984.1 | 1276 | PREDICTED: sterol regulatory element-binding protein cleavage-activating protein isoform X1 [Rattus norvegicus] |
| GI:155369287 | RefSeq | XP_006243985.1 | 1276 | PREDICTED: sterol regulatory element-binding protein cleavage-activating protein isoform X1 [Rattus norvegicus] |
| GI:155369287 | RefSeq | XP_006243986.1 | 1276 | PREDICTED: sterol regulatory element-binding protein cleavage-activating protein isoform X1 [Rattus norvegicus] |
| GI:155369287 | SwissProt | A2RRU4.1 | 1276 | RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein; Short=SCAP; Short=SREBP cleavage-activating protein [Rattus norvegicus] |