Gene/Proteome Database (LMPD)

LMPD ID
LMP013199
Gene ID
301059
Species
Rattus norvegicus (Rat)
Gene Name
myeloid differentiation primary response 88
Gene Symbol
Myd88
Alternate Names
myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene 88;
Chromosome
8
Map Location
8q32
Summary
an adaptor protein which binds toll-like receptors and links them to other downstream signalling molecules [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Myd88

Proteins

myeloid differentiation primary response protein MyD88
Refseq ID NP_937763
Protein GI 37693503
UniProt ID Q6Y1S1
mRNA ID NM_198130
Length 296
MSAGGPRVGSVSVDSYLFSLPLVALNVGVRRRLSLFLNPRTTAAADWTSLAEEMGFEYLEIREFETRPDPTRSLLDAWQGRSGSSVGRLLELLALLDREDILYELKDRIEEDCQKYIRNQQKQESEKPLQVARVESSVPQTKELGGITTLDDPLGQTPELFDAFICYCPNDIEFVQEMIRQLEQTDYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGVQQKRLIPIKYKAMKKDFPSILRFITICDYTNPCTKSWFWTRLAKALSLP

Gene Information

Entrez Gene ID
301059
Gene Name
myeloid differentiation primary response 88
Gene Symbol
Myd88
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005886 IEA:Ensembl C plasma membrane
GO:0014069 IDA:RGD C postsynaptic density
GO:0043234 IDA:RGD C protein complex
GO:0005121 IDA:RGD F Toll binding
GO:0005149 IPI:RGD F interleukin-1 receptor binding
GO:0005102 IPI:RGD F receptor binding
GO:0070935 IEA:Ensembl P 3'-UTR-mediated mRNA stabilization
GO:0007254 IMP:RGD P JNK cascade
GO:0002755 IEA:Ensembl P MyD88-dependent toll-like receptor signaling pathway
GO:0008063 IDA:RGD P Toll signaling pathway
GO:0071260 IEA:Ensembl P cellular response to mechanical stimulus
GO:0019221 IMP:RGD P cytokine-mediated signaling pathway
GO:0050830 ISS:UniProtKB P defense response to Gram-positive bacterium
GO:0090557 IEA:Ensembl P establishment of endothelial intestinal barrier
GO:0016064 IEA:Ensembl P immunoglobulin mediated immune response
GO:0006954 IEA:UniProtKB-KW P inflammatory response
GO:0045087 IEA:UniProtKB-KW P innate immune response
GO:0031663 IEA:Ensembl P lipopolysaccharide-mediated signaling pathway
GO:0044130 IEA:Ensembl P negative regulation of growth of symbiont in host
GO:0043123 TAS:RGD P positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046330 IEA:Ensembl P positive regulation of JNK cascade
GO:0051092 IEA:Ensembl P positive regulation of NF-kappaB transcription factor activity
GO:0045080 IEA:Ensembl P positive regulation of chemokine biosynthetic process
GO:0032740 IEA:Ensembl P positive regulation of interleukin-17 production
GO:0032747 IEA:Ensembl P positive regulation of interleukin-23 production
GO:0032755 IEA:Ensembl P positive regulation of interleukin-6 production
GO:0050671 IEA:Ensembl P positive regulation of lymphocyte proliferation
GO:0048661 IMP:RGD P positive regulation of smooth muscle cell proliferation
GO:0032760 IEA:Ensembl P positive regulation of tumor necrosis factor production
GO:0050727 IEA:Ensembl P regulation of inflammatory response
GO:0070555 IEA:Ensembl P response to interleukin-1
GO:0002238 IEA:Ensembl P response to molecule of fungal origin
GO:0032494 IEA:Ensembl P response to peptidoglycan
GO:0009615 IEA:Ensembl P response to virus
GO:0045351 IEA:Ensembl P type I interferon biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko05143 African trypanosomiasis
rno05143 African trypanosomiasis
ko04210 Apoptosis
rno04210 Apoptosis
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
rno05161 Hepatitis B
ko05168 Herpes simplex infection
rno05168 Herpes simplex infection
ko05164 Influenza A
rno05164 Influenza A
ko05134 Legionellosis
rno05134 Legionellosis
ko05140 Leishmaniasis
rno05140 Leishmaniasis
ko05144 Malaria
rno05144 Malaria
ko05162 Measles
rno05162 Measles
rno04064 NF-kappa B signaling pathway
ko05133 Pertussis
rno05133 Pertussis
ko05132 Salmonella infection
rno05132 Salmonella infection
ko04620 Toll-like receptor signaling pathway
rno04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
rno05145 Toxoplasmosis
ko05152 Tuberculosis
rno05152 Tuberculosis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953551 Activated TLR4 signalling
5953536 Cytokine Signaling in Immune system
5953792 Cytosolic sensors of pathogen-associated DNA
5953794 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
5953410 Immune System
5953409 Innate Immune System
5953797 Interleukin-1 signaling
5953565 MyD88 cascade initiated on plasma membrane
5953562 MyD88 dependent cascade initiated on endosome
5953559 MyD88-independent cascade
5953550 MyD88:Mal cascade initiated on plasma membrane
5953789 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
5953790 RIP-mediated NFkB activation via ZBP1
5953381 Signal Transduction
5953535 Signaling by Interleukins
5953395 Signalling by NGF
5953787 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
5954373 TRAF6 mediated IRF7 activation
5954377 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
5953788 TRAF6 mediated NF-kB activation
5953561 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
5953558 TRIF-mediated TLR3/TLR4 signaling
5953566 Toll Like Receptor 10 (TLR10) Cascade
5953555 Toll Like Receptor 2 (TLR2) Cascade
5953560 Toll Like Receptor 3 (TLR3) Cascade
5953552 Toll Like Receptor 4 (TLR4) Cascade
5953567 Toll Like Receptor 5 (TLR5) Cascade
5953564 Toll Like Receptor 7/8 (TLR7/8) Cascade
5953563 Toll Like Receptor 9 (TLR9) Cascade
5953554 Toll Like Receptor TLR1:TLR2 Cascade
5953556 Toll Like Receptor TLR6:TLR2 Cascade
5953553 Toll-Like Receptors Cascades
5953791 ZBP1(DAI) mediated induction of type I IFNs
5953945 p75 NTR receptor-mediated signalling
5953946 p75NTR recruits signalling complexes
5953947 p75NTR signals via NF-kB

Domain Information

InterPro Annotations

Accession Description
IPR011029 DEATH-like_dom
IPR000488 Death_domain
IPR017281 Myelin_different_resp_MyD88
IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

UniProt Annotations

Entry Information

Gene Name
myeloid differentiation primary response 88
Protein Entry
MYD88_RAT
UniProt ID
Q6Y1S1
Species
Rat

Comments

Comment Type Description
Domain The intermediate domain (ID) is required for the phosphorylation and activation of IRAK
Function Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity)
Similarity Contains 1 TIR domain. {ECO:0000255|PROSITE- ProRule:PRU00204}.
Similarity Contains 1 death domain. {ECO:0000255|PROSITE- ProRule:PRU00064}.
Subcellular Location Cytoplasm .
Subunit Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013199 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
37693503 RefSeq NP_937763 296 myeloid differentiation primary response protein MyD88

Identical Sequences to LMP013199 proteins

Reference Database Accession Length Protein Name
GI:37693503 GenBank AAO91937.1 296 myeloid differentiation primary response gene 88 [Rattus norvegicus]

Related Sequences to LMP013199 proteins

Reference Database Accession Length Protein Name
GI:37693503 GenBank AAO91937.1 296 myeloid differentiation primary response gene 88 [Rattus norvegicus]
GI:37693503 GenBank AAH97266.1 296 Myeloid differentiation primary response gene 88 [Rattus norvegicus]
GI:37693503 GenBank EDL76917.1 296 myeloid differentiation primary response gene 88 [Rattus norvegicus]
GI:37693503 SwissProt Q6Y1S1.2 296 RecName: Full=Myeloid differentiation primary response protein MyD88 [Rattus norvegicus]