Gene/Proteome Database (LMPD)

LMPD ID
LMP013220
Gene ID
303252
Species
Rattus norvegicus (Rat)
Gene Name
arachidonate 12-lipoxygenase, epidermal
Gene Symbol
Alox12e
Synonyms
12-LOX;
Alternate Names
arachidonate 12-lipoxygenase, epidermal-type; arachidonate lipoxygenase, epidermal;
Chromosome
10
Map Location
10q24
EC Number
1.13.11.31;

Proteins

arachidonate 12-lipoxygenase, epidermal-type
Refseq ID NP_001100484
Protein GI 157822649
UniProt ID D3ZQF9
mRNA ID NM_001107014
Length 662
MGKYKILVVTGDSLLAGSTNLVQLWLVGEHAEADLGKQLRPLRGRKTELEIDVPLHLGRLLVVKLRKHKGLLDSDWFCKWITVQGPGIQGEAFFPCYSWVQGKETIYLPEGTALKVNDDTKNLFRKYREQELEDRRNVYRWGSWKEGLILPIAGSTERDLPRNQRFMEDKDLDFSLSLAKVLKDFAIKGTLDFVSRVQHLEDYQKVFPHSKTALAGRVRDSWKEDALFGYQFLNGANPMLLRRSKRLPARLVLPPGMEDLQTQLEKELKAGSLFEADFSLLDGVKPNVIIFKQQHVAAPLVMLKLQSDGRLLPMVIQLQPPRHGCPPPLLFLPSDPPMAWLLAKIWVRSSDFQVHQLQSHLLRGHLMAEVISVATMRSLPSLHPIYKLLAPHFRYTMEINTLARNNLVSEWGIFDLVVSTGSGGHVDILQRATACLTYRSFCPPDDLADRGLLDVKSSLYARDALRLWEIISRYVGRMVELFYKNDREVKEDPELQVWCREVTEIGLLGAQDRGFPLSLESRAQLCRFVTMCIFTCTGQHASTHLGQLDWYSWIPNGPCTMRKPPPTSKNVTEGDILDALPCLQQARMQITFTKFLGRHQPVMVALGQHKEEYFSDPGARAVLKQFQEELAVMDKEIEVRNASLDLPYEYLRPSMVENSVTI

Gene Information

Entrez Gene ID
303252
Gene Name
arachidonate 12-lipoxygenase, epidermal
Gene Symbol
Alox12e
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0004052 IEA:UniProtKB-EC F arachidonate 12-lipoxygenase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0019369 IDA:UniProtKB P arachidonic acid metabolic process
GO:0019372 IDA:UniProtKB P lipoxygenase pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
rno01100 Metabolic pathways
rno04726 Serotonergic synapse

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR020834 Lipoxygenase, conserved site
IPR013819 Lipoxygenase, C-terminal
IPR020833 Lipoxygenase, iron binding site
IPR001885 Lipoxygenase, mammalian
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
arachidonate 12-lipoxygenase, epidermal
Protein Entry
LX12E_RAT
UniProt ID
D3ZQF9
Species
Rat

Comments

Comment Type Description
Catalytic Activity Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)- 12-hydroperoxyicosa-5,8,10,14-tetraenoate.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence= ; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
Function Non-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE
Pathway Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
Similarity Belongs to the lipoxygenase family
Similarity Contains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular Location Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00726}.

Identical and Related Proteins

Unique RefSeq proteins for LMP013220 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157822649 RefSeq NP_001100484 662 arachidonate 12-lipoxygenase, epidermal-type

Identical Sequences to LMP013220 proteins

Reference Database Accession Length Protein Name
GI:157822649 GenBank EDM04999.1 662 arachidonate lipoxygenase, epidermal (predicted) [Rattus norvegicus]
GI:157822649 SwissProt D3ZQF9.1 662 RecName: Full=Arachidonate 12-lipoxygenase, epidermal-type; Short=12-LOX [Rattus norvegicus]

Related Sequences to LMP013220 proteins

Reference Database Accession Length Protein Name
GI:157822649 GenBank AAC52324.1 662 arachidonate lipoxygenase [Mus musculus]
GI:157822649 GenBank EDM04999.1 662 arachidonate lipoxygenase, epidermal (predicted) [Rattus norvegicus]
GI:157822649 RefSeq NP_663717.1 662 arachidonate 12-lipoxygenase, epidermal-type [Mus musculus]
GI:157822649 SwissProt D3ZQF9.1 662 RecName: Full=Arachidonate 12-lipoxygenase, epidermal-type; Short=12-LOX [Rattus norvegicus]