Gene/Proteome Database (LMPD)

LMPD ID
LMP013233
Gene ID
303729
Species
Rattus norvegicus (Rat)
Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 7
Gene Symbol
Enpp7
Synonyms
E-NPP 7;
Alternate Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 7; NPP-7; E-NPP7; alk-SMase; intestinal alkaline sphingomyelinase; sphingomyelinase, intestinal alkaline; alkaline sphingomyelin phosphodiesterase;
Chromosome
10
Map Location
10q32.3
EC Number
3.1.4.12

Proteins

ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor
Refseq ID NP_001012484
Protein GI 60223065
UniProt ID Q5EZ72
mRNA ID NM_001012466
Length 439
MGHSAVLLSVALVILPACVTGGPVQRQQQHKLLLVSFDGFRWNYDQDVETPNLDSMAQEGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTNKVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRANVDTVMKWFTEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLTDSLNLIITSDHGMTTVNKKASDLVEFHKFPNFTFRDIEFELLDYGPNGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFNSGEHGFDNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPNDGHPGVLQPMLRSGSPLSRQHHLVVVLMGILTGLAKVV
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2052 peptide sequence: MGHSAVLLSVALVILPACVTG mat_peptide: 22..439 product: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q5EZ72.1) calculated_mol_wt: 47804 peptide sequence: GPVQRQQQHKLLLVSFDGFRWNYDQDVETPNLDSMAQEGVKARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNMFYNTTNKVRLPYHATLGIQRWWDNGSIPIWITAQRQGLKTGSFFYPGGNVTYQGEAVTMSRKEGVLHNYKNETEWRANVDTVMKWFTEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRHHLTDSLNLIITSDHGMTTVNKKASDLVEFHKFPNFTFRDIEFELLDYGPNGMLIPKEGMLEKVYSVLKDAHPRLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFNSGEHGFDNQDMDMKTIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPNDGHPGVLQPMLRSGSPLSRQHHLVVVLMGILTGLAKVV

Gene Information

Entrez Gene ID
303729
Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 7
Gene Symbol
Enpp7
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
IPR017850 Alkaline-phosphatase-like, core domain
IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

UniProt Annotations

Entry Information

Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 7
Protein Entry
ENPP7_RAT
UniProt ID
Q5EZ72
Species
Rat

Comments

Comment Type Description
Biophysicochemical Properties pH dependence: Optimum pH is 9.0. ;
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Function Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.
Ptm N-glycosylated; required for activity and transport to the plasma membrane
Similarity Belongs to the nucleotide pyrophosphatase/phosphodiesterase family
Subcellular Location Membrane ; Single-pass type I membrane protein . Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex
Tissue Specificity Highly expressed in the jejunum

Identical and Related Proteins

Unique RefSeq proteins for LMP013233 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
60223065 RefSeq NP_001012484 439 ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor

Identical Sequences to LMP013233 proteins

Reference Database Accession Length Protein Name
GI:60223065 GenBank AAU03450.1 439 intestinal alkaline sphingomyelinase [Rattus norvegicus]
GI:60223065 SwissProt Q5EZ72.1 439 RecName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; Short=E-NPP 7; Short=NPP-7; AltName: Full=Alkaline sphingomyelin phosphodiesterase; AltName: Full=Intestinal alkaline sphingomyelinase; Short=Alk-SMase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013233 proteins

Reference Database Accession Length Protein Name
GI:60223065 DBBJ BAE25908.1 439 unnamed protein product [Mus musculus]
GI:60223065 DBBJ BAE39727.1 439 unnamed protein product [Mus musculus]
GI:60223065 GenBank AAU03450.1 439 intestinal alkaline sphingomyelinase [Rattus norvegicus]
GI:60223065 SwissProt Q5EZ72.1 439 RecName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; Short=E-NPP 7; Short=NPP-7; AltName: Full=Alkaline sphingomyelin phosphodiesterase; AltName: Full=Intestinal alkaline sphingomyelinase; Short=Alk-SMase; Flags: Precursor [Rattus norvegicus]