Gene/Proteome Database (LMPD)
LMPD ID
LMP013252
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 9
Gene Symbol
Alternate Names
glycerol-3-phosphate acyltransferase 3; GPAT3; GPAT-3; 1-AGPAT 9; LPAAT-theta; 1-AGP acyltransferase 9; lysophosphatidic acid acyltransferase theta; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9;
Chromosome
14
Map Location
14p22
EC Number
2.3.1.15
Proteins
| glycerol-3-phosphate acyltransferase 3 | |
|---|---|
| Refseq ID | NP_001020841 |
| Protein GI | 71043846 |
| UniProt ID | Q4V8J4 |
| mRNA ID | NM_001025670 |
| Length | 457 |
| MEGTDLVVKLLSTWLTLVGSLILLPSAFGLSLGISEIYMKILVKTLEWATLRIEKGAPKESVLKSPASMGIIQRDESPMEKGLSGLRGRDFELSDVFYFSKKGLEAIVEDEVTQRFSSEELVSWNLLTRTNVNFHYISPKLTIVWVLGVLVRYCFLLPLRVTLAFIGISLLIIGTTLVGQLPDSSLKNWLSELVHLTCCRICVRSLSGTIHYHNKQYRPQKGGICVANHTSPIDVLILATDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERSEIKDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIYPVAIKYNPQFGDAFWNSSKYNLVSYLLRIMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAIAVQGGLTELPWDGGLKRAKVKDTFKEEQQKTYSKMIVGNGSPSLALDSSTVDNHGSPEPAFRSESL | |
Gene Information
Entrez Gene ID
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 9
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | ISS:UniProtKB | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0003841 | IEA:UniProtKB-EC | F | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| GO:0004366 | ISS:UniProtKB | F | glycerol-3-phosphate O-acyltransferase activity |
| GO:0016024 | IEA:UniProtKB-UniPathway | P | CDP-diacylglycerol biosynthetic process |
| GO:0032006 | IEA:Ensembl | P | regulation of TOR signaling |
| GO:0019432 | ISS:UniProtKB | P | triglyceride biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00561 | Glycerolipid metabolism |
| rno00561 | Glycerolipid metabolism |
| ko00564 | Glycerophospholipid metabolism |
| rno00564 | Glycerophospholipid metabolism |
| rno01100 | Metabolic pathways |
| M00089 | Triacylglycerol biosynthesis |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002123 | Phospholipid/glycerol acyltransferase |
UniProt Annotations
Entry Information
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 9
Protein Entry
GPAT3_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. |
| Catalytic Activity | Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate. |
| Caution | Despite its name, the human ortholog of this protein appears to lack measurable glycerol-3-phosphate acyltransferase activity under some conditions (PMID:19318427) |
| Domain | The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate |
| Function | May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid, or PA) (By similarity) |
| Pathway | Glycerolipid metabolism; triacylglycerol biosynthesis. |
| Pathway | Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. |
| Similarity | Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . |
Identical and Related Proteins
Unique RefSeq proteins for LMP013252 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 71043846 | RefSeq | NP_001020841 | 457 | glycerol-3-phosphate acyltransferase 3 |
Identical Sequences to LMP013252 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71043846 | RefSeq | XP_008768241.1 | 457 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X1 [Rattus norvegicus] |
| GI:71043846 | RefSeq | XP_008768242.1 | 457 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X1 [Rattus norvegicus] |
| GI:71043846 | RefSeq | XP_008768243.1 | 457 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X1 [Rattus norvegicus] |
| GI:71043846 | SwissProt | Q4V8J4.1 | 457 | RecName: Full=Glycerol-3-phosphate acyltransferase 3; Short=GPAT-3; AltName: Full=1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; Short=1-AGP acyltransferase 9; Short=1-AGPAT 9; AltName: Full=Lysophosphatidic acid acyltransferase theta; Short=LPAAT-theta [Rattus norvegicus] |
Related Sequences to LMP013252 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71043846 | GenBank | AAH97362.1 | 457 | 1-acylglycerol-3-phosphate O-acyltransferase 9 [Rattus norvegicus] |
| GI:71043846 | RefSeq | XP_008768242.1 | 457 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X1 [Rattus norvegicus] |
| GI:71043846 | RefSeq | XP_008768243.1 | 457 | PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X1 [Rattus norvegicus] |
| GI:71043846 | SwissProt | Q4V8J4.1 | 457 | RecName: Full=Glycerol-3-phosphate acyltransferase 3; Short=GPAT-3; AltName: Full=1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; Short=1-AGP acyltransferase 9; Short=1-AGPAT 9; AltName: Full=Lysophosphatidic acid acyltransferase theta; Short=LPAAT-theta [Rattus norvegicus] |