Gene/Proteome Database (LMPD)
LMPD ID
LMP013255
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
steroid 5 alpha-reductase 3
Gene Symbol
Synonyms
S5AR 3; RGD1308828;
Alternate Names
polyprenol reductase; SR type 3; steroid 5-alpha-reductase 3; probable polyprenol reductase; 3-oxo-5-alpha-steroid 4-dehydrogenase 3;
Chromosome
14
Map Location
14p11
EC Number
1.3.1.94
Proteins
| polyprenol reductase | |
|---|---|
| Refseq ID | NP_001014012 |
| Protein GI | 62078709 |
| UniProt ID | Q5RJM1 |
| mRNA ID | NM_001013990 |
| Length | 278 |
| MAGWAGAELSVLNPLRALWLLLAAAFLLALLLQLAPARLLPSCALFQDLIRYGKTKQSGSRRPAVCRAFDVPKRYFSHFYVVSVLWNGSLLWFLSQSLFLGAPFPSWLWALLRTLGVTQFQALGMESKASRIQAGELALSTFLVLVFLWVHSLRRLFECFYVSVFSNTAIHVVQYCFGLVYYVLVGLTVLSQVPMNDKNVYALGKNLLLQARWFHILGMMMFFWSSAHQYKCHVILSNLRRNKKGVVIHCQHRIPFGDWFELYGEERSPGDRFPSSRR | |
Gene Information
Entrez Gene ID
Gene Name
steroid 5 alpha-reductase 3
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | ISS:UniProtKB | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0003865 | ISS:UniProtKB | F | 3-oxo-5-alpha-steroid 4-dehydrogenase activity |
| GO:0047751 | IEA:UniProtKB-EC | F | cholestenone 5-alpha-reductase activity |
| GO:0016628 | ISS:UniProtKB | F | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| GO:0019348 | ISS:UniProtKB | P | dolichol metabolic process |
| GO:0006488 | ISS:UniProtKB | P | dolichol-linked oligosaccharide biosynthetic process |
| GO:0016095 | ISS:UniProtKB | P | polyprenol catabolic process |
| GO:0006486 | IEA:UniProtKB-UniPathway | P | protein glycosylation |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00140 | Steroid hormone biosynthesis |
| rno00140 | Steroid hormone biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953941 | Androgen biosynthesis |
| 5953739 | Asparagine N-linked glycosylation |
| 5953738 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5953345 | Metabolism of proteins |
| 5953937 | Metabolism of steroid hormones and vitamin D |
| 5953728 | Post-translational protein modification |
| 5953925 | Synthesis of Dolichyl-phosphate |
| 5953737 | Synthesis of substrates in N-glycan biosythesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR001104 | 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5RJM1-1; Sequence=Displayed; Name=2; IsoId=Q5RJM1-2; Sequence=VSP_039791; Note=No experimental confirmation available.; |
| Catalytic Activity | A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH |
| Catalytic Activity | Ditrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH |
| Function | Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) |
| Pathway | Protein modification; protein glycosylation. |
| Similarity | Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Expressed in the 2 tissues tested i.e. testis and liver |
Identical and Related Proteins
Unique RefSeq proteins for LMP013255 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 62078709 | RefSeq | NP_001014012 | 278 | polyprenol reductase |
Identical Sequences to LMP013255 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:62078709 | GenBank | AAH86584.1 | 278 | Steroid 5 alpha-reductase 3 [Rattus norvegicus] |
Related Sequences to LMP013255 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:62078709 | GenBank | AAQ38211.1 | 330 | Sequence 144 from patent US 6573095 |
| GI:62078709 | GenBank | AAQ38268.1 | 330 | Sequence 278 from patent US 6573095 |
| GI:62078709 | GenBank | AAH86584.1 | 278 | Steroid 5 alpha-reductase 3 [Rattus norvegicus] |
| GI:62078709 | RefSeq | XP_006250959.1 | 330 | PREDICTED: polyprenol reductase isoform X1 [Rattus norvegicus] |