Gene/Proteome Database (LMPD)
LMPD ID
LMP013259
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Gene Symbol
Alternate Names
phosphatidylinositol 4-kinase type 2-beta; phosphatidylinositol 4-kinase type II-beta; phosphatidylinositol 4-kinase type-II beta;
Chromosome
14
Map Location
14q11
EC Number
2.7.1.67
Proteins
| phosphatidylinositol 4-kinase type 2-beta | |
|---|---|
| Refseq ID | NP_001005883 |
| Protein GI | 54400734 |
| UniProt ID | Q5XIL2 |
| mRNA ID | NM_001005883 |
| Length | 477 |
| MPEPPRDIMAEACEATRPSEDEDEEREPLLPRVAWAQPRRGAPGSAVRLQADQGAAVLREPATEEPPVVSEDRSISASLSTELDRTRNAVSETNTFLEDPEFADVVLKAEQAIEIGVFPERISQGSSGSYFVKDSKRTIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLLPNQGYLSEAGAYLVDTKLQLGIVPKTKVVWLVSETFNYSAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKIGSFQLFVKDYKEAEYWLRRFEAEPLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVKYDEMKYAKKIESEESNWIDDKQLLIRIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEETRNLILPFISDMNFVQDLCEDLYELFKTDKGFDRAAFESQMSVMRGQILNLTQALRDGKSPMQLAQMPCVIVECSKSGGQGRVVHLGSSFTQTVHCRKPFFSSW | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0004430 | IEA:UniProtKB-EC | F | 1-phosphatidylinositol 4-kinase activity |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00562 | Inositol phosphate metabolism |
| rno00562 | Inositol phosphate metabolism |
| M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
| rno01100 | Metabolic pathways |
| ko04070 | Phosphatidylinositol signaling system |
| rno04070 | Phosphatidylinositol signaling system |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5954478 | PI Metabolism |
| 5953474 | Phospholipid metabolism |
| 5954501 | Synthesis of PIPs at the ER membrane |
| 5954502 | Synthesis of PIPs at the Golgi membrane |
| 5954503 | Synthesis of PIPs at the early endosome membrane |
| 5954499 | Synthesis of PIPs at the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Protein Entry
P4K2B_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
| Enzyme Regulation | Recruited and activated by membrane association. Binding to the microsomal membrane has been shown to enhance its activity (By similarity) |
| Function | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity) |
| Similarity | Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily |
| Similarity | Contains 1 PI3K/PI4K domain |
| Subcellular Location | Cytoplasm . Membrane . Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP013259 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 54400734 | RefSeq | NP_001005883 | 477 | phosphatidylinositol 4-kinase type 2-beta |
Identical Sequences to LMP013259 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:54400734 | GenBank | AAH83668.1 | 477 | Phosphatidylinositol 4-kinase type 2 beta [Rattus norvegicus] |
| GI:54400734 | GenBank | EDL99884.1 | 477 | phosphatidylinositol 4-kinase type 2 beta, isoform CRA_a [Rattus norvegicus] |
| GI:54400734 | SwissProt | Q5XIL2.1 | 477 | RecName: Full=Phosphatidylinositol 4-kinase type 2-beta; AltName: Full=Phosphatidylinositol 4-kinase type II-beta [Rattus norvegicus] |
Related Sequences to LMP013259 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:54400734 | GenBank | AAH62144.1 | 469 | Phosphatidylinositol 4-kinase type 2 beta [Mus musculus] |
| GI:54400734 | GenBank | AAH83668.1 | 477 | Phosphatidylinositol 4-kinase type 2 beta [Rattus norvegicus] |
| GI:54400734 | GenBank | EDL99884.1 | 477 | phosphatidylinositol 4-kinase type 2 beta, isoform CRA_a [Rattus norvegicus] |
| GI:54400734 | SwissProt | Q5XIL2.1 | 477 | RecName: Full=Phosphatidylinositol 4-kinase type 2-beta; AltName: Full=Phosphatidylinositol 4-kinase type II-beta [Rattus norvegicus] |