Gene/Proteome Database (LMPD)

LMPD ID
LMP013293
Gene ID
308100
Species
Rattus norvegicus (Rat)
Gene Name
acetyl-CoA acetyltransferase 2
Gene Symbol
Acat2
Synonyms
Acat3; Ab2-076;
Alternate Names
acetyl-CoA acetyltransferase, cytosolic; cytosolic acetoacetyl-CoA thiolase; acetyl-Coenzyme A acetyltransferase 2; acetyl-Coenzyme A acetyltransferase 3;
Chromosome
1
Map Location
1q11
EC Number
2.3.1.9

Proteins

acetyl-CoA acetyltransferase, cytosolic
Refseq ID NP_001006996
Protein GI 55741502
UniProt ID Q5XI22
mRNA ID NM_001006995
Length 397
MNAGSDPVVIISAARTAIGSFNGALSTVPVHNLGTTVIKEVLQRAKVAPEEVSEVIFGHVLTAGCGQNPTRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAAQSIAMGDSTIVVAGGMENMSKAPHLAHLRSGVKMGEVPLADSILCDGLTDAFHNYHMGITAENVAKKWQVSREAQDKVAVVSQNRAEHAQKAGHFDKEIVPVHVSSRKGLTEVKIDEFPRHGSNLEAMSKLKPYFLTDGTGTVTPANASGMNDGAAAVVLMKKTEAESRMLKPLAQVVSWSQAGVEPSVMGVGPIPAIKQAVAKAGWSLEDVDVFEINEAFAAVSAAIAKELGLSPEKVNIDGGAIALGHPLGASGCRILVTLLHTLERVGGTRGVAALCIGGGMGIAMCVQRG

Gene Information

Entrez Gene ID
308100
Gene Name
acetyl-CoA acetyltransferase 2
Gene Symbol
Acat2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0003985 IDA:RGD F acetyl-CoA C-acetyltransferase activity
GO:0007420 IEP:RGD P brain development
GO:0071398 IEP:RGD P cellular response to fatty acid
GO:0031670 IEP:RGD P cellular response to nutrient
GO:0046952 IEP:RGD P ketone body catabolic process
GO:0001889 IEP:RGD P liver development

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
ko01200 Carbon metabolism
rno01200 Carbon metabolism
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko00630 Glyoxylate and dicarboxylate metabolism
rno00630 Glyoxylate and dicarboxylate metabolism
ko00310 Lysine degradation
rno00310 Lysine degradation
rno01100 Metabolic pathways
ko00640 Propanoate metabolism
rno00640 Propanoate metabolism
ko00620 Pyruvate metabolism
rno00620 Pyruvate metabolism
ko00072 Synthesis and degradation of ketone bodies
rno00072 Synthesis and degradation of ketone bodies
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis
ko00380 Tryptophan metabolism
rno00380 Tryptophan metabolism
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA acetyltransferase 2
Protein Entry
THIC_RAT
UniProt ID
Q5XI22
Species
Rat

Comments

Comment Type Description
Catalytic Activity 2 acetyl-CoA = CoA + acetoacetyl-CoA
Similarity Belongs to the thiolase family
Subcellular Location Cytoplasm .
Subunit Homotetramer

Identical and Related Proteins

Unique RefSeq proteins for LMP013293 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
55741502 RefSeq NP_001006996 397 acetyl-CoA acetyltransferase, cytosolic

Identical Sequences to LMP013293 proteins

Reference Database Accession Length Protein Name
GI:55741502 GenBank AAH83872.1 397 Acetyl-Coenzyme A acetyltransferase 2 [Rattus norvegicus]
GI:55741502 GenBank EDL83695.1 397 rCG40752, isoform CRA_c [Rattus norvegicus]
GI:55741502 SwissProt Q5XI22.1 397 RecName: Full=Acetyl-CoA acetyltransferase, cytosolic; AltName: Full=Cytosolic acetoacetyl-CoA thiolase [Rattus norvegicus]

Related Sequences to LMP013293 proteins

Reference Database Accession Length Protein Name
GI:55741502 GenBank AAH83872.1 397 Acetyl-Coenzyme A acetyltransferase 2 [Rattus norvegicus]
GI:55741502 GenBank EDL83695.1 397 rCG40752, isoform CRA_c [Rattus norvegicus]
GI:55741502 RefSeq NP_033364.2 397 acetyl-CoA acetyltransferase, cytosolic [Mus musculus]
GI:55741502 SwissProt Q5XI22.1 397 RecName: Full=Acetyl-CoA acetyltransferase, cytosolic; AltName: Full=Cytosolic acetoacetyl-CoA thiolase [Rattus norvegicus]