Gene/Proteome Database (LMPD)

LMPD ID
LMP013295
Gene ID
308451
Species
Rattus norvegicus (Rat)
Gene Name
inositol-trisphosphate 3-kinase C
Gene Symbol
Itpkc
Alternate Names
inositol-trisphosphate 3-kinase C; IP3K C; IP3K-C; IP3 3-kinase C; insP 3-kinase C; inositol 1,4,5-trisphosphate 3-kinase C;
Chromosome
1
Map Location
1q21
EC Number
2.7.1.127
Summary
kinase involved in converting inositol 1,4,5-trisphosphate to inositol 1,3,4,5-tetrakisphosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Itpkc

Proteins

inositol-trisphosphate 3-kinase C
Refseq ID NP_835195
Protein GI 30017415
UniProt ID Q80ZG2
mRNA ID NM_178094
Length 678
MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEGFSLHSEAERTDFGPAPCPDGPQAEPCGDEHEECEAAGLGVASEKPSQNKELDGSNLQTHPKLSSPLAEMEMAGSWTDGFRTDLHRPDLQARPKRASLCTQPGFDESWTELDRSELWQTLPERDKPWVDHLRTHQDMSRLQNHPACPSPEPSAGTSCKELSADGSRTPHDTDGFWIESQTDGSLIGPSTQTACRQPANDGFSAQDTDGTLIQPGTDDGPWVDSVLEKSNGDDPLMEPEPRDLVTNLCSHLECSSLCPVPRLIITSESPEPGAQPLGPQARIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRSGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPTYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDVGILRKYVARLEDLRDTLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWAEGNREDGYLWGLDNLICLLQGLAQS

Gene Information

Entrez Gene ID
308451
Gene Name
inositol-trisphosphate 3-kinase C
Gene Symbol
Itpkc
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008440 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0016301 IDA:RGD F kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954514 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol-trisphosphate 3-kinase C
Protein Entry
IP3KC_RAT
UniProt ID
Q80ZG2
Species
Rat

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=0.2 uM for Ins(1,4,5)P3 ; KM=1.5 uM for Ins(2,4,5)P3 ; KM=33 uM for ATP ;
Catalytic Activity ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme Regulation Activated by Ca(2+)/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.
Function Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate
Similarity Belongs to the inositol phosphokinase (IPK) family
Subcellular Location Nucleus . Cytoplasm . Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
Tissue Specificity Highly expressed in tongue epithelium, taste papilla, heart, brain and testis. Weakly expressed in lung, liver and kidney

Identical and Related Proteins

Unique RefSeq proteins for LMP013295 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30017415 RefSeq NP_835195 678 inositol-trisphosphate 3-kinase C

Identical Sequences to LMP013295 proteins

Reference Database Accession Length Protein Name
GI:30017415 EMBL CAD29464.1 678 inositol 1,4,5-trisphosphate 3-kinase [Rattus norvegicus]
GI:30017415 GenBank AAO20335.1 678 inositol 1,4,5-trisphosphate 3-kinase C [Rattus norvegicus]
GI:30017415 GenBank EDM07966.1 678 inositol 1,4,5-trisphosphate 3-kinase C [Rattus norvegicus]
GI:30017415 SwissProt Q80ZG2.1 678 RecName: Full=Inositol-trisphosphate 3-kinase C; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase C; Short=IP3 3-kinase C; Short=IP3K C; Short=InsP 3-kinase C [Rattus norvegicus]

Related Sequences to LMP013295 proteins

Reference Database Accession Length Protein Name
GI:30017415 EMBL CAD29464.1 678 inositol 1,4,5-trisphosphate 3-kinase [Rattus norvegicus]
GI:30017415 GenBank AAO20335.1 678 inositol 1,4,5-trisphosphate 3-kinase C [Rattus norvegicus]
GI:30017415 GenBank EDM07966.1 678 inositol 1,4,5-trisphosphate 3-kinase C [Rattus norvegicus]
GI:30017415 SwissProt Q80ZG2.1 678 RecName: Full=Inositol-trisphosphate 3-kinase C; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase C; Short=IP3 3-kinase C; Short=IP3K C; Short=InsP 3-kinase C [Rattus norvegicus]