Gene/Proteome Database (LMPD)

LMPD ID
LMP013303
Gene ID
308909
Species
Rattus norvegicus (Rat)
Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbol
Smpd1
Alternate Names
sphingomyelin phosphodiesterase;
Chromosome
1
Map Location
1q33
EC Number
3.1.4.12

Proteins

sphingomyelin phosphodiesterase
Refseq ID NP_001006998
Protein GI 55741778
UniProt ID Q5XIA6
mRNA ID NM_001006997
Length 627
MPHHGASSGQGHLRAGWEQRLERSLPAPKLGLLWMGLGLALVLALFDSTVLWVPARAYPLPSQGHSVKFSAVAPQLQNAFGWRNLTCPACKVLFTALNYGLKKEPNVARVGSVAIKMCKMLNIAPLNVCQSAVHLFEDDVVDVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHDYLEGTDPNCADPLCCRRGSGWPPNSRTGAGYWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALNTITDLVWKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVDELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLGPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAPGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRADEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDAHSLWSRPLLC

Gene Information

Entrez Gene ID
308909
Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbol
Smpd1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:RGD C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0042599 IDA:RGD C lamellar body
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity
GO:0046513 IMP:RGD P ceramide biosynthetic process
GO:0043407 IEA:Ensembl P negative regulation of MAP kinase activity
GO:0043065 IMP:RGD P positive regulation of apoptotic process
GO:0035307 IEA:Ensembl P positive regulation of protein dephosphorylation
GO:0042220 IDA:RGD P response to cocaine
GO:0042493 IEP:RGD P response to drug
GO:0006685 IEA:InterPro P sphingomyelin catabolic process
GO:0023021 IEA:Ensembl P termination of signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
ko04142 Lysosome
rno04142 Lysosome
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954485 Glycosphingolipid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
IPR008139 Saposin B
IPR011001 Saposin-like
IPR011160 Sphingomyelin phosphodiesterase

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Protein Entry
Q5XIA6_RAT
UniProt ID
Q5XIA6
Species
Rat

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine
Function Converts sphingomyelin to ceramide
Similarity Belongs to the acid sphingomyelinase family

Identical and Related Proteins

Unique RefSeq proteins for LMP013303 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
55741778 RefSeq NP_001006998 627 sphingomyelin phosphodiesterase

Identical Sequences to LMP013303 proteins

Reference Database Accession Length Protein Name
GI:55741778 GenBank AAH83780.1 627 Sphingomyelin phosphodiesterase 1, acid lysosomal [Rattus norvegicus]
GI:55741778 GenBank EDM18044.1 627 sphingomyelin phosphodiesterase 1, acid lysosomal, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP013303 proteins

Reference Database Accession Length Protein Name
GI:55741778 DBBJ BAC40171.1 627 unnamed protein product [Mus musculus]
GI:55741778 GenBank AAH83780.1 627 Sphingomyelin phosphodiesterase 1, acid lysosomal [Rattus norvegicus]
GI:55741778 GenBank EDM18044.1 627 sphingomyelin phosphodiesterase 1, acid lysosomal, isoform CRA_a [Rattus norvegicus]
GI:55741778 RefSeq NP_035551.1 627 sphingomyelin phosphodiesterase precursor [Mus musculus]