Gene/Proteome Database (LMPD)

LMPD ID
LMP013308
Gene ID
309129
Species
Rattus norvegicus (Rat)
Gene Name
FCH domain only 2
Gene Symbol
Fcho2
Synonyms
RGD1565396;
Alternate Names
FCH domain only protein 2;
Chromosome
2
Map Location
2q12

Proteins

FCH domain only protein 2
Refseq ID NP_001178561
Protein GI 300798518
mRNA ID NM_001191632
Length 855
MRPGGRGRSLGRRRRRRREAGAPWGPVRVYTAAGGCGRGTRRGGGTMVMAHFVENFWGEKNNGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQAIQNITQALQKSKENYNAKCVEQERLKKEGATPREIEKAAVKSKKATDTYKLYVEKYALTKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNMANTTIESLIQKFAESKGTGKERPGLIEFEECDPASAVEGIKPRKRKTFALPGIIKKEKDAESVECPDADSLNIPDVDEEGFSIKPEANQNDTKENHFYSSSDSDSEDEEPKRYRIEIKPVHPNNVHHTMASLDELKVSIGNITLSPAVSRHSPVQMNRNSSNEELTKSKPSSLPTEKGTNDLLAWDPLFGSSLESSSAPLTSSSSARPTTPLSLGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPITSNTSPPPTAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAIALTESVNAYFKGADPTKCIVKITGDVTISFPSGIIKVFTSNPSPAVLCFRVKNISRLEQILPNSQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSGISEKSDSGGSGSLRAKFDLSEGPSKPATLAVQFLSEGNTLSGVDIELVGTGYRLSLVKKRFATGRYLADC

Gene Information

Entrez Gene ID
309129
Gene Name
FCH domain only 2
Gene Symbol
Fcho2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030136 IEA:Ensembl C clathrin-coated vesicle
GO:0005905 ISS:UniProtKB C coated pit
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0035091 ISS:UniProtKB F phosphatidylinositol binding
GO:0005546 ISS:UniProtKB F phosphatidylinositol-4,5-bisphosphate binding
GO:0001786 ISS:UniProtKB F phosphatidylserine binding
GO:0048268 ISS:UniProtKB P clathrin coat assembly
GO:0072583 ISS:UniProtKB P clathrin-mediated endocytosis
GO:0010324 ISS:UniProtKB P membrane invagination
GO:0072659 ISS:UniProtKB P protein localization to plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR001060 FCH domain
IPR028565 Mu homology domain
IPR018808 Muniscin C-terminal

UniProt Annotations

Entry Information

Gene Name
FCH domain only 2
Species
Rat

Comments

Comment Type Description
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor (By similarity). {ECO:0000250}.
Ptm Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity). {ECO:0000250}.
Similarity Belongs to the FCHO family. {ECO:0000305}.
Similarity Contains 1 FCH domain. {ECO:0000255|PROSITE- ProRule:PRU00083}.
Similarity Contains 1 MHD (mu homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00404}.
Subcellular Location Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.
Subunit Homodimer; disulfide-linked. May form homotetramer. Interacts with AP2A1. Interacts with EPS15, EPS15R, ITSN1 and ITSN2; recruit those scaffolding proteins which in turn may interact with the adaptor protein complex AP-2 at the plasma membrane. Interacts with DAB2 (via DPF motifs); mediates LDL receptor/LDLR endocytosis (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitously expressed (at protein level). {ECO:0000269|PubMed:21762413}.

Identical and Related Proteins

Unique RefSeq proteins for LMP013308 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
300798518 RefSeq NP_001178561 855 FCH domain only protein 2

Identical Sequences to LMP013308 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP013308 proteins

Reference Database Accession Length Protein Name
GI:300798518 DBBJ BAE25007.1 809 unnamed protein product [Mus musculus]
GI:300798518 RefSeq NP_766179.2 809 FCH domain only protein 2 [Mus musculus]
GI:300798518 SwissProt Q3UQN2.1 809 RecName: Full=FCH domain only protein 2 [Mus musculus]
GI:300798518 SwissProt D3ZYR1.1 809 RecName: Full=FCH domain only protein 2 [Rattus norvegicus]