Gene/Proteome Database (LMPD)

LMPD ID
LMP013311
Gene ID
309212
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin D2 receptor 2
Gene Symbol
Ptgdr2
Synonyms
Gpr44;
Alternate Names
prostaglandin D2 receptor 2; G protein-coupled receptor 44;
Chromosome
1
Map Location
1q43

Proteins

prostaglandin D2 receptor 2
Refseq ID NP_001012070
Protein GI 58865714
UniProt ID Q6XKD3
mRNA ID NM_001012070
Length 403
MANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLSTGPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQEKQGSLSCTLD

Gene Information

Entrez Gene ID
309212
Gene Name
prostaglandin D2 receptor 2
Gene Symbol
Ptgdr2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004930 ISS:UniProtKB F G-protein coupled receptor activity
GO:0004956 ISS:UniProtKB F prostaglandin D receptor activity
GO:0004958 IEA:Ensembl F prostaglandin F receptor activity
GO:0001785 IEA:Ensembl F prostaglandin J receptor activity
GO:0007186 ISS:UniProtKB P G-protein coupled receptor signaling pathway
GO:0007193 IEA:Ensembl P adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0019722 ISS:UniProtKB P calcium-mediated signaling
GO:0006935 ISS:UniProtKB P chemotaxis
GO:0045745 IEA:Ensembl P positive regulation of G-protein coupled receptor protein signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5954152 G alpha (i) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954201 Prostanoid ligand receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM

UniProt Annotations

Entry Information

Gene Name
prostaglandin D2 receptor 2
Protein Entry
PD2R2_RAT
UniProt ID
Q6XKD3
Species
Rat

Comments

Comment Type Description
Domain The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for ADRBK1/GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-351 is a major site for PKC-induced internalization of the receptor (By similarity)
Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity)
Ptm Phosphorylated
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane ; Multi-pass membrane protein . Note=Internalized receptors colocalized with RAB11A

Identical and Related Proteins

Unique RefSeq proteins for LMP013311 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865714 RefSeq NP_001012070 403 prostaglandin D2 receptor 2

Identical Sequences to LMP013311 proteins

Reference Database Accession Length Protein Name
GI:58865714 GenBank EDM12854.1 403 rCG48174 [Rattus norvegicus]
GI:58865714 RefSeq XP_006231102.1 403 PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus]
GI:58865714 RefSeq XP_008758453.1 403 PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus]
GI:58865714 SwissProt Q6XKD3.1 403 RecName: Full=Prostaglandin D2 receptor 2; AltName: Full=G protein-coupled receptor 44 [Rattus norvegicus]

Related Sequences to LMP013311 proteins

Reference Database Accession Length Protein Name
GI:58865714 GenBank AAP57088.1 403 G protein-coupled receptor 44 [Rattus norvegicus]
GI:58865714 GenBank EDM12854.1 403 rCG48174 [Rattus norvegicus]
GI:58865714 RefSeq XP_006231102.1 403 PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus]
GI:58865714 RefSeq XP_008758453.1 403 PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus]