Gene/Proteome Database (LMPD)

LMPD ID
LMP013311
Gene ID
309212
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin D2 receptor 2
Gene Symbol
Ptgdr2
Synonyms
Gpr44;
Alternate Names
prostaglandin D2 receptor 2; G protein-coupled receptor 44;
Chromosome
1
Map Location
1q43

Proteins

prostaglandin D2 receptor 2
Refseq ID NP_001012070
Protein GI 58865714
UniProt ID Q6XKD3
mRNA ID NM_001012070
Length 403
MANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLSTGPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQEKQGSLSCTLD

Gene Information

Entrez Gene ID
309212
Gene Name
prostaglandin D2 receptor 2
Gene Symbol
Ptgdr2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004930 ISS:UniProtKB F G-protein coupled receptor activity
GO:0004956 ISS:UniProtKB F prostaglandin D receptor activity
GO:0004958 IEA:Ensembl F prostaglandin F receptor activity
GO:0001785 IEA:Ensembl F prostaglandin J receptor activity
GO:0007193 IEA:Ensembl P adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0019722 ISS:UniProtKB P calcium-mediated signaling
GO:0006935 ISS:UniProtKB P chemotaxis
GO:0007186 ISS:UniProtKB P G-protein coupled receptor signaling pathway
GO:0045745 IEA:Ensembl P positive regulation of G-protein coupled receptor protein signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5954152 G alpha (i) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954201 Prostanoid ligand receptors
5953391 Signaling by GPCR
5953381 Signal Transduction

Domain Information

InterPro Annotations

Accession Description
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000276 G protein-coupled receptor, rhodopsin-like

UniProt Annotations

Entry Information

Gene Name
prostaglandin D2 receptor 2
Protein Entry
PD2R2_RAT
UniProt ID
Q6XKD3
Species
Rat

Comments

Comment Type Description
Domain The 329-DSEL-332 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for ADRBK1/GRK2 and GPRK5/GRK5 to promote agonist-induced internalization (By similarity). Thr-351 is a major site for PKC-induced internalization of the receptor (By similarity)
Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity)
Ptm Phosphorylated
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane ; Multi-pass membrane protein . Note=Internalized receptors colocalized with RAB11A

Identical and Related Proteins

Unique RefSeq proteins for LMP013311 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865714 RefSeq NP_001012070 403 prostaglandin D2 receptor 2

Identical Sequences to LMP013311 proteins

Reference Database Accession Length Protein Name
GI:58865714 GenBank EDM12854.1 403 rCG48174 [Rattus norvegicus]
GI:58865714 RefSeq XP_006231102.1 403 PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus]
GI:58865714 RefSeq XP_008758453.1 403 PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus]
GI:58865714 SwissProt Q6XKD3.1 403 RecName: Full=Prostaglandin D2 receptor 2; AltName: Full=G protein-coupled receptor 44 [Rattus norvegicus]

Related Sequences to LMP013311 proteins

Reference Database Accession Length Protein Name
GI:58865714 GenBank AAP57088.1 403 G protein-coupled receptor 44 [Rattus norvegicus]
GI:58865714 GenBank EDM12854.1 403 rCG48174 [Rattus norvegicus]
GI:58865714 RefSeq XP_006231102.1 403 PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus]
GI:58865714 RefSeq XP_008758453.1 403 PREDICTED: prostaglandin D2 receptor 2 isoform X1 [Rattus norvegicus]