Gene/Proteome Database (LMPD)

LMPD ID
LMP013313
Gene ID
309288
Species
Rattus norvegicus (Rat)
Gene Name
RAR-related orphan receptor B
Gene Symbol
Rorb
Alternate Names
nuclear receptor ROR-beta; transcription factor; nuclear receptor RZR-beta; RAR-related orphan receptor beta; retinoid-related orphan receptor-beta; nuclear receptor subfamily 1 group F member 2;
Chromosome
1
Map Location
1q43
Summary
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
Orthologs
View orthologs and multiple alignments for Rorb

Proteins

nuclear receptor ROR-beta
Refseq ID NP_001257887
Protein GI 400974222
mRNA ID NM_001270958
Length 459
MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNTETGGTYANGHVIDLPKSEGYYNIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLLEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFNPDCAAVCK

Gene Information

Entrez Gene ID
309288
Gene Name
RAR-related orphan receptor B
Gene Symbol
Rorb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 ISS:UniProtKB C nucleus
GO:0004879 IEA:InterPro F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008502 IDA:RGD F melatonin receptor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IDA:UniProtKB F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0007186 IDA:GOC P G-protein coupled receptor signaling pathway
GO:0035881 ISS:UniProtKB P amacrine cell differentiation
GO:0007420 IEP:RGD P brain development
GO:0071300 IDA:UniProtKB P cellular response to retinoic acid
GO:0007623 IEP:RGD P circadian rhythm
GO:0042462 ISS:UniProtKB P eye photoreceptor cell development
GO:0045668 ISS:UniProtKB P negative regulation of osteoblast differentiation
GO:0045892 IDA:UniProtKB P negative regulation of transcription, DNA-templated
GO:0045893 IDA:UniProtKB P positive regulation of transcription, DNA-templated
GO:0042752 ISS:UniProtKB P regulation of circadian rhythm
GO:0009725 IEP:RGD P response to hormone
GO:0060041 ISS:UniProtKB P retina development in camera-type eye
GO:0046549 ISS:UniProtKB P retinal cone cell development
GO:0046548 ISS:UniProtKB P retinal rod cell development
GO:0007601 IEA:UniProtKB-KW P visual perception

KEGG Pathway Links

KEGG Pathway ID Description
ko04710 Circadian rhythm
rno04710 Circadian rhythm

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR003079 ROR_rcpt
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
RAR-related orphan receptor B
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative promoter usage; Named isoforms=2; Name=2; Synonyms=ROR-beta 2; IsoId=P45446-2; Sequence=Displayed; Note=Shows a 4-fold higher transcriptional activation of an optimal promoter compared to isoform 1.; Name=1; Synonyms=ROR-beta 1; IsoId=P45446-1; Sequence=VSP_022577;
Domain AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity (PubMed:8816759 and PubMed:11689423). {ECO:0000269|PubMed:11689423, ECO:0000269|PubMed:8816759}.
Function Isoform 1: Critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity). {ECO:0000250}.
Function Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity. {ECO:0000269|PubMed:12958591, ECO:0000269|PubMed:8816759}.
Induction Isoform 2 oscillates diurnally in eye and pineal gland, with highest levels shortly after midnight. {ECO:0000269|PubMed:9729429}.
Sequence Caution Sequence=AAA42095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Monomer. Interacts with CRX. {ECO:0000269|PubMed:11689423, ECO:0000269|PubMed:12958591, ECO:0000269|PubMed:8816759}.
Tissue Specificity Isoform 2 expressed with circadian rhythm in eye and pineal gland. Isoform 1 expressed in retina cortex, thalamus, and hypothalamus. {ECO:0000269|PubMed:9670004, ECO:0000269|PubMed:9729429}.

Identical and Related Proteins

Unique RefSeq proteins for LMP013313 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
400974222 RefSeq NP_001257887 459 nuclear receptor ROR-beta

Identical Sequences to LMP013313 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP013313 proteins

Reference Database Accession Length Protein Name
GI:400974222 GenBank AAA42095.1 483 transcription factor, partial [Rattus norvegicus]
GI:400974222 GenBank ABG77269.1 459 retinoid-related orphan receptor beta 1 isoform [Mus musculus]
GI:400974222 RefSeq NP_001036819.1 459 nuclear receptor ROR-beta isoform 1 [Mus musculus]
GI:400974222 RefSeq XP_006985477.1 459 PREDICTED: nuclear receptor ROR-beta isoform X2 [Peromyscus maniculatus bairdii]