Gene/Proteome Database (LMPD)

LMPD ID
LMP013328
Gene ID
310773
Species
Rattus norvegicus (Rat)
Gene Name
choline/ethanolamine phosphotransferase 1
Gene Symbol
Cept1
Alternate Names
choline/ethanolaminephosphotransferase 1;
Chromosome
2
Map Location
2q34
EC Number
2.7.8.1

Proteins

choline/ethanolaminephosphotransferase 1
Refseq ID NP_001007700
Protein GI 56090333
UniProt ID Q6AXM5
mRNA ID NM_001007699
Length 416
MSGHRSTRKRCGDSHPESPVGFGHMSTTGCILNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVGRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQIFIIIMHLLAVIGGPPFWQSMIPVLNIQMKLFPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAVMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKTSTAHSNHH

Gene Information

Entrez Gene ID
310773
Gene Name
choline/ethanolamine phosphotransferase 1
Gene Symbol
Cept1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004142 IEA:UniProtKB-EC F diacylglycerol cholinephosphotransferase activity
GO:0004307 IEA:UniProtKB-EC F ethanolaminephosphotransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006646 IEA:UniProtKB-UniPathway P phosphatidylethanolamine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00565 Ether lipid metabolism
rno00565 Ether lipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954091 Synthesis of PC
5954474 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase
IPR014472 Choline/ethanolamine phosphotransferase

UniProt Annotations

Entry Information

Gene Name
choline/ethanolamine phosphotransferase 1
Protein Entry
CEPT1_RAT
UniProt ID
Q6AXM5
Species
Rat

Comments

Comment Type Description
Catalytic Activity CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.
Catalytic Activity CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Function Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity (By similarity)
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . Nucleus membrane {ECO:0000250}; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013328 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
56090333 RefSeq NP_001007700 416 choline/ethanolaminephosphotransferase 1

Identical Sequences to LMP013328 proteins

Reference Database Accession Length Protein Name
GI:56090333 GenBank EDL81841.1 416 choline/ethanolamine phosphotransferase 1, isoform CRA_a [Rattus norvegicus]
GI:56090333 RefSeq XP_006233178.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Rattus norvegicus]
GI:56090333 RefSeq XP_006233180.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Rattus norvegicus]
GI:56090333 SwissProt Q6AXM5.1 416 RecName: Full=Choline/ethanolaminephosphotransferase 1 [Rattus norvegicus]

Related Sequences to LMP013328 proteins

Reference Database Accession Length Protein Name
GI:56090333 GenBank AAH79471.1 416 Choline/ethanolamine phosphotransferase 1 [Rattus norvegicus]
GI:56090333 GenBank EDL81841.1 416 choline/ethanolamine phosphotransferase 1, isoform CRA_a [Rattus norvegicus]
GI:56090333 RefSeq XP_006233178.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Rattus norvegicus]
GI:56090333 RefSeq XP_006233180.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Rattus norvegicus]