Gene/Proteome Database (LMPD)

LMPD ID
LMP013331
Gene ID
310849
Species
Rattus norvegicus (Rat)
Gene Name
sphingomyelin synthase 2
Gene Symbol
Sgms2
Synonyms
spermatin; RGD1305778;
Alternate Names
phosphatidylcholine:ceramide cholinephosphotransferase 2;
Chromosome
2
Map Location
2q43
EC Number
2.7.8.27

Proteins

phosphatidylcholine:ceramide cholinephosphotransferase 2
Refseq ID NP_001014065
Protein GI 62078817
UniProt ID Q4JM44
mRNA ID NM_001014043
Length 365
MDIIETAKLEGHLESQTNNSTNTYTSPTEAVEEEDKNGKGKPKTLSNGLRKGAKKYPDYIQISMPNDSRNKLPLEWWKTGIAFVYALFNLILTTVMITVVHERVPPKELSPPLPDKFFDYVDRVKWAFSVSEINGMVLVGLWLTQWLFLRYKSIVGRRFFFIMGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKIQRILRLLSGGGLSITGSHILCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIVCILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST

Gene Information

Entrez Gene ID
310849
Gene Name
sphingomyelin synthase 2
Gene Symbol
Sgms2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 IEA:Ensembl C integral component of Golgi membrane
GO:0045203 IDA:UniProtKB C integral component of cell outer membrane
GO:0005887 IEA:Ensembl C integral component of plasma membrane
GO:0047493 IEA:Ensembl F ceramide cholinephosphotransferase activity
GO:0016301 IEA:UniProtKB-KW F kinase activity
GO:0033188 IEA:UniProtKB-EC F sphingomyelin synthase activity
GO:0006686 IEA:Ensembl P sphingomyelin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954266 Sphingolipid de novo biosynthesis
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR025749 Sphingomyelin synthase-like domain

UniProt Annotations

Entry Information

Gene Name
sphingomyelin synthase 2
Protein Entry
SMS2_RAT
UniProt ID
Q4JM44
Species
Rat

Comments

Comment Type Description
Catalytic Activity A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity (By similarity)
Ptm Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization
Similarity Belongs to the sphingomyelin synthase family
Subcellular Location Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Note=Predominantly plasma membrane, some in Golgi apparatus
Tissue Specificity Expression restricted to late round spermatids and elongating spermatids but not detected in late elongate spermatids and Sertoli cells (at protein level)

Identical and Related Proteins

Unique RefSeq proteins for LMP013331 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62078817 RefSeq NP_001014065 365 phosphatidylcholine:ceramide cholinephosphotransferase 2

Identical Sequences to LMP013331 proteins

Reference Database Accession Length Protein Name
GI:62078817 GenBank EDL82215.1 365 similar to RIKEN cDNA 4933405A16, isoform CRA_a [Rattus norvegicus]
GI:62078817 GenBank EDL82216.1 365 similar to RIKEN cDNA 4933405A16, isoform CRA_a [Rattus norvegicus]
GI:62078817 RefSeq XP_006233373.1 365 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1 [Rattus norvegicus]
GI:62078817 RefSeq XP_008759723.1 365 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1 [Rattus norvegicus]

Related Sequences to LMP013331 proteins

Reference Database Accession Length Protein Name
GI:62078817 GenBank EDL82215.1 365 similar to RIKEN cDNA 4933405A16, isoform CRA_a [Rattus norvegicus]
GI:62078817 GenBank EDL82216.1 365 similar to RIKEN cDNA 4933405A16, isoform CRA_a [Rattus norvegicus]
GI:62078817 RefSeq XP_006233373.1 365 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1 [Rattus norvegicus]
GI:62078817 RefSeq XP_008759723.1 365 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1 [Rattus norvegicus]