Gene/Proteome Database (LMPD)

LMPD ID
LMP013343
Gene ID
311849
Species
Rattus norvegicus (Rat)
Gene Name
carnitine O-acetyltransferase
Gene Symbol
Crat
Alternate Names
carnitine O-acetyltransferase; CAT; carnitine acetylase; carnitine acetyltransferase;
Chromosome
3
Map Location
3p12
EC Number
2.3.1.7
Summary
catalyzes the reversible transfer of an acyl group from acyl-CoA thioesters to carnitine; key enzyme in mitochondrial and endoplasmic reticulum metabolic pathways [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Crat

Proteins

carnitine O-acetyltransferase
Refseq ID NP_001004085
Protein GI 51854229
UniProt ID Q704S8
mRNA ID NM_001004085
Length 626
MLAFAARTVVKPLGLLKPSSLMKVSGRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQTSGGVGERLQKGLERRAKKMENWLSEWWLKTAYLQFRQPVVIYSSPGVLLPKQDFMDLQGQLRFAAKLIEGVLDFKSMIDNETLPVEFLGGQPLCMNQYYQILSSCRVPGLKQDSVVNFLKSKKPPTHITVVHNYQFFELDVYHSDGTPLTSDQIFVQLEKIWNSSLQSNKEPVGILTSNHRNSWAKAYSSLIKDKVNRESVNSIQKSIFTVCLDKQVPRVSDDVYRSHVAGQMLHGGGSKFNSGNRWFDKTLQFIVAEDGSCGMVYEHAAAEGPPIVALVDHVMEYTKKPELVRSPMVPLPMPKKLRFNITPEIKNDIEKAKQNISIMIQDLDIMMLVFHHFGKDFPKSQKLSPDAFIQIALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASTDSLAFVKGMDDPKVPEQQRVELLRKAVQAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMSFGPVVPDGYGICYNPMEAHINFSVSAYNSCAETNAARMAHYLEKALLDMRTLLQNHPRAKL

Gene Information

Entrez Gene ID
311849
Gene Name
carnitine O-acetyltransferase
Gene Symbol
Crat
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 TAS:RGD C endoplasmic reticulum
GO:0005743 IEA:UniProtKB-KW C mitochondrial inner membrane
GO:0005739 TAS:RGD C mitochondrion
GO:0005777 TAS:RGD C peroxisome
GO:0004092 IDA:RGD F carnitine O-acetyltransferase activity
GO:0006631 IDA:RGD P fatty acid metabolic process
GO:0006810 IEA:UniProtKB-KW P transport

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
rno04146 Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6111 mitochondrial L-carnitine shuttle

REACTOME Pathway Links

REACTOME Pathway ID Description
5954181 Beta-oxidation of pristanoyl-CoA
5954188 Beta-oxidation of very long chain fatty acids
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953470 Peroxisomal lipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine O-acetyltransferase
Protein Entry
CACP_RAT
UniProt ID
Q704S8
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + carnitine = CoA + O- acetylcarnitine.
Function Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria (By similarity)
Similarity Belongs to the carnitine/choline acetyltransferase family
Subcellular Location Endoplasmic reticulum . Peroxisome . Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein ; Matrix side .
Subunit Monomer
Tissue Specificity Expressed in flagella of epididymal sperm

Identical and Related Proteins

Unique RefSeq proteins for LMP013343 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51854229 RefSeq NP_001004085 626 carnitine O-acetyltransferase

Identical Sequences to LMP013343 proteins

Reference Database Accession Length Protein Name
GI:51854229 EMBL CAF06525.1 626 Carnitine O-acetyltransferase [Rattus norvegicus]
GI:51854229 GenBank AAH83616.1 626 Carnitine acetyltransferase [Rattus norvegicus]
GI:51854229 SwissProt Q704S8.1 626 RecName: Full=Carnitine O-acetyltransferase; Short=Carnitine acetylase; AltName: Full=Carnitine acetyltransferase; Short=CAT; Short=CrAT [Rattus norvegicus]

Related Sequences to LMP013343 proteins

Reference Database Accession Length Protein Name
GI:51854229 EMBL CAF06525.1 626 Carnitine O-acetyltransferase [Rattus norvegicus]
GI:51854229 GenBank AAH83616.1 626 Carnitine acetyltransferase [Rattus norvegicus]
GI:51854229 RefSeq XP_008759885.1 626 PREDICTED: carnitine O-acetyltransferase isoform X1 [Rattus norvegicus]
GI:51854229 SwissProt Q704S8.1 626 RecName: Full=Carnitine O-acetyltransferase; Short=Carnitine acetylase; AltName: Full=Carnitine acetyltransferase; Short=CAT; Short=CrAT [Rattus norvegicus]