Gene/Proteome Database (LMPD)

LMPD ID
LMP013350
Gene ID
312781
Species
Rattus norvegicus (Rat)
Gene Name
low density lipoprotein receptor-related protein 6
Gene Symbol
Lrp6
Alternate Names
low-density lipoprotein receptor-related protein 6;
Chromosome
4
Map Location
4q43

Proteins

low-density lipoprotein receptor-related protein 6
Refseq ID NP_001101362
Protein GI 157823966
UniProt ID D3ZUH9
mRNA ID NM_001107892
Length 1234
MYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYEERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLESGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYVYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMAGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYFEPTTILQAVQLPALCTAHYTLQH

Gene Information

Entrez Gene ID
312781
Gene Name
low density lipoprotein receptor-related protein 6
Gene Symbol
Lrp6
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0005901 IBA:RefGenome C caveola
GO:0009986 IBA:RefGenome C cell surface
GO:0031410 IEA:Ensembl C cytoplasmic vesicle
GO:0005769 IEA:Ensembl C early endosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043025 IDA:RGD C neuronal cell body
GO:0005886 IBA:RefGenome C plasma membrane
GO:0043235 IBA:RefGenome C receptor complex
GO:0045202 IDA:RGD C synapse
GO:0042813 IBA:RefGenome F Wnt-activated receptor activity
GO:0017147 IBA:RefGenome F Wnt-protein binding
GO:0034185 IBA:RefGenome F apolipoprotein binding
GO:0015026 IBA:RefGenome F coreceptor activity
GO:0071936 IEA:Ensembl F coreceptor activity involved in Wnt signaling pathway
GO:0019210 IEA:Ensembl F kinase inhibitor activity
GO:0005041 IBA:RefGenome F low-density lipoprotein receptor activity
GO:0019534 IEA:Ensembl F toxin transporter activity
GO:0044332 IBA:RefGenome P Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0021874 IEA:Ensembl P Wnt signaling pathway involved in forebrain neuroblast division
GO:0090244 IBA:RefGenome P Wnt signaling pathway involved in somitogenesis
GO:0009952 IBA:RefGenome P anterior/posterior pattern specification
GO:0090245 IBA:RefGenome P axis elongation involved in somitogenesis
GO:0060349 IBA:RefGenome P bone morphogenesis
GO:0046849 IBA:RefGenome P bone remodeling
GO:0060444 IBA:RefGenome P branching involved in mammary gland duct morphogenesis
GO:0060070 IMP:RGD P canonical Wnt signaling pathway
GO:0061310 IEA:Ensembl P canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0061324 IEA:Ensembl P canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0042074 IEA:Ensembl P cell migration involved in gastrulation
GO:0071397 IEA:Ensembl P cellular response to cholesterol
GO:0021587 IBA:RefGenome P cerebellum morphogenesis
GO:0021795 IEA:Ensembl P cerebral cortex cell migration
GO:0021987 IBA:RefGenome P cerebral cortex development
GO:0060026 IBA:RefGenome P convergent extension
GO:0071542 IEA:Ensembl P dopaminergic neuron differentiation
GO:0048596 IBA:RefGenome P embryonic camera-type eye morphogenesis
GO:0042733 IEA:Ensembl P embryonic digit morphogenesis
GO:0035115 IEA:Ensembl P embryonic forelimb morphogenesis
GO:0035116 IEA:Ensembl P embryonic hindlimb morphogenesis
GO:0030326 IBA:RefGenome P embryonic limb morphogenesis
GO:0009880 IBA:RefGenome P embryonic pattern specification
GO:0060059 IBA:RefGenome P embryonic retina morphogenesis in camera-type eye
GO:0035261 IBA:RefGenome P external genitalia morphogenesis
GO:0060325 IBA:RefGenome P face morphogenesis
GO:0021861 IEA:Ensembl P forebrain radial glial cell differentiation
GO:0021943 IEA:Ensembl P formation of radial glial scaffolds
GO:0001702 IBA:RefGenome P gastrulation with mouth forming second
GO:0001947 IEA:Ensembl P heart looping
GO:0060596 IEA:Ensembl P mammary placode formation
GO:0030901 IBA:RefGenome P midbrain development
GO:0030917 IBA:RefGenome P midbrain-hindbrain boundary development
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:0045599 IEA:Ensembl P negative regulation of fat cell differentiation
GO:2000151 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000168 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in neural tube closure
GO:2000164 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000149 IEA:Ensembl P negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0071901 IEA:Ensembl P negative regulation of protein serine/threonine kinase activity
GO:0034392 IEA:Ensembl P negative regulation of smooth muscle cell apoptotic process
GO:0014033 IBA:RefGenome P neural crest cell differentiation
GO:0014029 IBA:RefGenome P neural crest formation
GO:0001843 IBA:RefGenome P neural tube closure
GO:0042475 IBA:RefGenome P odontogenesis of dentin-containing tooth
GO:0060021 IBA:RefGenome P palate development
GO:0003344 IBA:RefGenome P pericardium morphogenesis
GO:2000055 IEA:Ensembl P positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0045780 IEA:Ensembl P positive regulation of bone resorption
GO:0090263 IEA:Ensembl P positive regulation of canonical Wnt signaling pathway
GO:0045787 IEA:Ensembl P positive regulation of cell cycle
GO:0007204 IMP:RGD P positive regulation of cytosolic calcium ion concentration
GO:0002053 IEA:Ensembl P positive regulation of mesenchymal cell proliferation
GO:0045778 IEA:Ensembl P positive regulation of ossification
GO:0051091 IBA:RefGenome P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944 IBA:RefGenome P positive regulation of transcription from RNA polymerase II promoter
GO:0036342 IEA:Ensembl P post-anal tail morphogenesis
GO:0090009 IBA:RefGenome P primitive streak formation
GO:0090118 IBA:RefGenome P receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0060284 IEA:Ensembl P regulation of cell development
GO:0045598 IBA:RefGenome P regulation of fat cell differentiation
GO:0030278 IBA:RefGenome P regulation of ossification
GO:0006355 IMP:RGD P regulation of transcription, DNA-templated
GO:0051593 IEA:Ensembl P response to folic acid
GO:0043434 IEP:RGD P response to peptide hormone
GO:0016337 IMP:RGD P single organismal cell-cell adhesion
GO:0007268 IMP:RGD P synaptic transmission
GO:0021794 IBA:RefGenome P thalamus development
GO:0060535 IBA:RefGenome P trachea cartilage morphogenesis

KEGG Pathway Links

KEGG Pathway ID Description
ko04310 Wnt signaling pathway
rno04310 Wnt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953253 Disease
5954027 RNF mutants show enhanced WNT signaling and proliferation
5953381 Signal Transduction
5953965 Signaling by WNT in cancer
5953803 Signaling by Wnt
5954025 TCF dependent signaling in response to WNT
5954028 XAV939 inhibits tankyrase, stabilizing AXIN
5954029 disassembly of the destruction complex and recruitment of AXIN to the membrane
5954026 misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
5954626 negative regulation of TCF-dependent signaling by WNT ligand antagonists
5954637 regulation of FZD by ubiquitination

Domain Information

InterPro Annotations

Accession Description
IPR000742 Epidermal growth factor-like domain
IPR000033 LDLR class B repeat
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
IPR011042 Six-bladed beta-propeller, TolB-like

UniProt Annotations

Entry Information

Gene Name
low density lipoprotein receptor-related protein 6
Protein Entry
D3ZUH9_RAT
UniProt ID
D3ZUH9
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP013350 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157823966 RefSeq NP_001101362 1234 low-density lipoprotein receptor-related protein 6

Identical Sequences to LMP013350 proteins

Reference Database Accession Length Protein Name
GI:157823966 GenBank EDM01658.1 1234 low density lipoprotein receptor-related protein 6 (predicted) [Rattus norvegicus]

Related Sequences to LMP013350 proteins

Reference Database Accession Length Protein Name
GI:157823966 GenBank EDM01658.1 1234 low density lipoprotein receptor-related protein 6 (predicted) [Rattus norvegicus]
GI:157823966 RefSeq XP_001501348.1 1613 PREDICTED: low-density lipoprotein receptor-related protein 6 isoform 1 [Equus caballus]
GI:157823966 RefSeq XP_006237581.1 1613 PREDICTED: low-density lipoprotein receptor-related protein 6 isoform X1 [Rattus norvegicus]
GI:157823966 RefSeq XP_006976604.1 1462 PREDICTED: low-density lipoprotein receptor-related protein 6 [Peromyscus maniculatus bairdii]