Gene/Proteome Database (LMPD)

LMPD ID
LMP013353
Gene ID
312952
Species
Rattus norvegicus (Rat)
Gene Name
inositol monophosphatase domain containing 1
Gene Symbol
Impad1
Synonyms
IMP 3; gPAPP; RGD1306455;
Alternate Names
inositol monophosphatase 3; Ac2-190; IMPase 3; golgi-resident PAP phosphatase; myo-inositol monophosphatase A3; inositol-1(or 4)-monophosphatase 3; inositol monophosphatase domain-containing protein 1; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase;
Chromosome
17
Map Location
chromosome:17
EC Number
3.1.3.25

Proteins

inositol monophosphatase 3
Refseq ID NP_001008772
Protein GI 291049776
UniProt ID D4AD37
mRNA ID NM_001008772
Length 356
MAPMGIRLSPLGVAVFFLLGLGVLYHLYSGFLAGRFSLFGLGGEPAGGAAEVAVDGGTVDLREMLAVAVLAAERGGDEVRRVRESNVLHEKSKGKTREGAEDKMTSGDVLSNRKMFYLLKTAFPNVQINTEEHVDASDKEVIVWNRKIPEDILKEIAAPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPVLGVIHKPFSEYTAWAMVDSGSNVKARSSYNEKTPKIIVSRSHAGMVKQVALQTFGNQTLIIPAGGAGYKVLALLDVPDMTQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLSGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKSGH

Gene Information

Entrez Gene ID
312952
Gene Name
inositol monophosphatase domain containing 1
Gene Symbol
Impad1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008441 IEA:UniProtKB-EC F 3'(2'),5'-bisphosphate nucleotidase activity
GO:0008934 IEA:UniProtKB-EC F inositol monophosphate 1-phosphatase activity
GO:0052832 IEA:UniProtKB-EC F inositol monophosphate 3-phosphatase activity
GO:0052833 IEA:UniProtKB-EC F inositol monophosphate 4-phosphatase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006021 IEA:UniProtKB-UniPathway P inositol biosynthetic process
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko00920 Sulfur metabolism
rno00920 Sulfur metabolism

Domain Information

InterPro Annotations

Accession Description
IPR020550 Inositol monophosphatase, conserved site
IPR000760 Inositol_monophosphatase

UniProt Annotations

Entry Information

Gene Name
inositol monophosphatase domain containing 1
Protein Entry
IMPA3_RAT
UniProt ID
D4AD37
Species
Rat

Comments

Comment Type Description
Catalytic Activity Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
Catalytic Activity Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
Enzyme Regulation Strongly inhibited by lithium.
Function May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation
Pathway Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2.
Ptm Contains N-linked glycan resistant to endoglycosydase H
Similarity Belongs to the inositol monophosphatase family
Subcellular Location Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013353 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
291049776 RefSeq NP_001008772 356 inositol monophosphatase 3

Identical Sequences to LMP013353 proteins

Reference Database Accession Length Protein Name
GI:291049776 GenBank EDM11627.1 356 inositol monophosphatase domain containing 1 [Rattus norvegicus]
GI:291049776 RefSeq XP_008774114.1 356 PREDICTED: inositol monophosphatase 3 [Rattus norvegicus]
GI:291049776 RefSeq XP_008761786.1 356 PREDICTED: inositol monophosphatase 3 [Rattus norvegicus]
GI:291049776 SwissProt D4AD37.1 356 RecName: Full=Inositol monophosphatase 3; Short=IMP 3; Short=IMPase 3; AltName: Full=Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Short=Golgi-resident PAP phosphatase; Short=gPAPP; AltName: Full=Inositol monophosphatase domain-containing protein 1; AltName: Full=Inositol-1(or 4)-monophosphatase 3; AltName: Full=Myo-inositol monophosphatase A3 [Rattus norvegicus]

Related Sequences to LMP013353 proteins

Reference Database Accession Length Protein Name
GI:291049776 GenBank EDM11627.1 356 inositol monophosphatase domain containing 1 [Rattus norvegicus]
GI:291049776 RefSeq XP_008774114.1 356 PREDICTED: inositol monophosphatase 3 [Rattus norvegicus]
GI:291049776 RefSeq XP_008761786.1 356 PREDICTED: inositol monophosphatase 3 [Rattus norvegicus]
GI:291049776 SwissProt D4AD37.1 356 RecName: Full=Inositol monophosphatase 3; Short=IMP 3; Short=IMPase 3; AltName: Full=Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Short=Golgi-resident PAP phosphatase; Short=gPAPP; AltName: Full=Inositol monophosphatase domain-containing protein 1; AltName: Full=Inositol-1(or 4)-monophosphatase 3; AltName: Full=Myo-inositol monophosphatase A3 [Rattus norvegicus]