Gene/Proteome Database (LMPD)

LMPD ID
LMP013378
Gene ID
314553
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylserine synthase 1
Gene Symbol
Ptdss1
Synonyms
PSS-1;
Alternate Names
phosphatidylserine synthase 1; ptdSer synthase 1; serine-exchange enzyme I;
Chromosome
7
Map Location
7q22
EC Number
2.7.8.29

Proteins

phosphatidylserine synthase 1
Refseq ID NP_001012113
Protein GI 58865796
UniProt ID Q5PQL5
mRNA ID NM_001012113
Length 473
MASCVGSRTLSKDDVNYRMHFRMINEQQVEDITIDFFYRPHTITLLSFTIISLMYFAFTRDDCVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADIMEYAVNCHVITWERIVSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLSWCRILFIGCITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVVLWLLCVAFTTFLCLYGMVWYAEHYGHREKTYSECEDGTYSPEISWYHGKGSKGSEDSPPKHSNNNESHSSRRRNRHSKSKVTNGVGKK

Gene Information

Entrez Gene ID
314553
Gene Name
phosphatidylserine synthase 1
Gene Symbol
Ptdss1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016740 IEA:UniProtKB-KW F transferase activity
GO:0006659 IEA:UniProtKB-UniPathway P phosphatidylserine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954479 Synthesis of PS

Domain Information

InterPro Annotations

Accession Description
IPR004277 Phosphatidyl serine synthase

UniProt Annotations

Entry Information

Gene Name
phosphatidylserine synthase 1
Protein Entry
PTSS1_RAT
UniProt ID
Q5PQL5
Species
Rat

Comments

Comment Type Description
Catalytic Activity L-1-phosphatidylethanolamine + L-serine = L-1- phosphatidylserine + ethanolamine.
Function Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity)
Pathway Phospholipid metabolism; phosphatidylserine biosynthesis.
Similarity Belongs to the phosphatidyl serine synthase family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . Note=Highly enriched in the mitochondria-associated membrane (MAM)

Identical and Related Proteins

Unique RefSeq proteins for LMP013378 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865796 RefSeq NP_001012113 473 phosphatidylserine synthase 1

Identical Sequences to LMP013378 proteins

Reference Database Accession Length Protein Name
GI:58865796 GenBank AAH87129.1 473 Phosphatidylserine synthase 1 [Rattus norvegicus]
GI:58865796 SwissProt Q5PQL5.1 473 RecName: Full=Phosphatidylserine synthase 1; Short=PSS-1; Short=PtdSer synthase 1; AltName: Full=Serine-exchange enzyme I [Rattus norvegicus]

Related Sequences to LMP013378 proteins

Reference Database Accession Length Protein Name
GI:58865796 GenBank AAH87129.1 473 Phosphatidylserine synthase 1 [Rattus norvegicus]
GI:58865796 GenBank ERE60460.1 473 phosphatidylserine synthase 1-like protein [Cricetulus griseus]
GI:58865796 RefSeq XP_005368204.1 473 PREDICTED: phosphatidylserine synthase 1 [Microtus ochrogaster]
GI:58865796 SwissProt Q5PQL5.1 473 RecName: Full=Phosphatidylserine synthase 1; Short=PSS-1; Short=PtdSer synthase 1; AltName: Full=Serine-exchange enzyme I [Rattus norvegicus]