Gene/Proteome Database (LMPD)

LMPD ID
LMP013382
Gene ID
315165
Species
Rattus norvegicus (Rat)
Gene Name
N-acetyl galactosaminidase, alpha
Gene Symbol
Naga
Alternate Names
alpha-N-acetylgalactosaminidase; alpha-galactosidase B;
Chromosome
7
Map Location
7q34
EC Number
3.2.1.49

Proteins

alpha-N-acetylgalactosaminidase precursor
Refseq ID NP_001012120
Protein GI 58865810
UniProt ID Q66H12
mRNA ID NM_001012120
Length 415
MLQKTVLLLALVAQVLMLENGLLRTPPMGWLAWERFRCNINCEEDPKNCISERLFMEMADRLAQDGWRDLGYVYLNIDDCWIGGRDATGRLIPDPKRFPHGIAFLADYAHSLGLKLGIYEDMGKMTCMGYPGTTLDKVELDAATFAEWKVDMLKLDGCYSTPKERAEGYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTEVAGTCNLWRNYKDIQDSWKSVLSILDWFVKHQDILQPVSGPGHWNDPDMLLIGNFGLSFDESRAQMALWTVLAAPLFMSTDLRTISPQNIDILQNPLLIKINQDPLGIQGRLIFKSKSHIEVFKRNLSDDASALVFFSRRTDMPYHFHCSLLELNYPKGSVYEGQNVFTGDIISGLHPETNFTVIINPSGVVMWYLYPVKGLGIYTMMSQL
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1884 peptide sequence: MLQKTVLLLALVAQVLM mat_peptide: 18..415 product: Alpha-N-acetylgalactosaminidase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q66H12.1) calculated_mol_wt: 45005 peptide sequence: LENGLLRTPPMGWLAWERFRCNINCEEDPKNCISERLFMEMADRLAQDGWRDLGYVYLNIDDCWIGGRDATGRLIPDPKRFPHGIAFLADYAHSLGLKLGIYEDMGKMTCMGYPGTTLDKVELDAATFAEWKVDMLKLDGCYSTPKERAEGYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTEVAGTCNLWRNYKDIQDSWKSVLSILDWFVKHQDILQPVSGPGHWNDPDMLLIGNFGLSFDESRAQMALWTVLAAPLFMSTDLRTISPQNIDILQNPLLIKINQDPLGIQGRLIFKSKSHIEVFKRNLSDDASALVFFSRRTDMPYHFHCSLLELNYPKGSVYEGQNVFTGDIISGLHPETNFTVIINPSGVVMWYLYPVKGLGIYTMMSQL

Gene Information

Entrez Gene ID
315165
Gene Name
N-acetyl galactosaminidase, alpha
Gene Symbol
Naga
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IBA:RefGenome C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0008456 ISS:UniProtKB F alpha-N-acetylgalactosaminidase activity
GO:0004557 IBA:RefGenome F alpha-galactosidase activity
GO:0016052 ISS:UniProtKB P carbohydrate catabolic process
GO:0019377 ISS:UniProtKB P glycolipid catabolic process
GO:0016139 IBA:RefGenome P glycoside catabolic process
GO:0046477 IBA:RefGenome P glycosylceramide catabolic process
GO:0009311 IBA:RefGenome P oligosaccharide metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00603 Glycosphingolipid biosynthesis - globo series
rno00603 Glycosphingolipid biosynthesis - globo series
ko04142 Lysosome
rno04142 Lysosome

Domain Information

InterPro Annotations

Accession Description
IPR013785 Aldolase-type TIM barrel
IPR017853 Glycoside hydrolase superfamily
IPR000111 Glycoside hydrolase, clan GH-D
IPR002241 Glycoside hydrolase, family 27
IPR013780 Glycosyl hydrolase, family 13, all-beta

UniProt Annotations

Entry Information

Gene Name
N-acetyl galactosaminidase, alpha
Protein Entry
NAGAB_RAT
UniProt ID
Q66H12
Species
Rat

Comments

Comment Type Description
Catalytic Activity Cleavage of non-reducing alpha-(1->3)-N- acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids.
Function Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (By similarity)
Similarity Belongs to the glycosyl hydrolase 27 family
Subcellular Location Lysosome .
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP013382 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865810 RefSeq NP_001012120 415 alpha-N-acetylgalactosaminidase precursor

Identical Sequences to LMP013382 proteins

Reference Database Accession Length Protein Name
GI:58865810 GenBank EDM15661.1 415 rCG59517, isoform CRA_b [Rattus norvegicus]
GI:58865810 RefSeq XP_006242149.1 415 PREDICTED: alpha-N-acetylgalactosaminidase isoform X1 [Rattus norvegicus]
GI:58865810 RefSeq XP_006242150.1 415 PREDICTED: alpha-N-acetylgalactosaminidase isoform X1 [Rattus norvegicus]
GI:58865810 SwissProt Q66H12.1 415 RecName: Full=Alpha-N-acetylgalactosaminidase; AltName: Full=Alpha-galactosidase B; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013382 proteins

Reference Database Accession Length Protein Name
GI:58865810 GenBank AAH82084.1 415 N-acetyl galactosaminidase, alpha [Rattus norvegicus]
GI:58865810 RefSeq XP_006242149.1 415 PREDICTED: alpha-N-acetylgalactosaminidase isoform X1 [Rattus norvegicus]
GI:58865810 RefSeq XP_006242150.1 415 PREDICTED: alpha-N-acetylgalactosaminidase isoform X1 [Rattus norvegicus]
GI:58865810 SwissProt Q66H12.1 415 RecName: Full=Alpha-N-acetylgalactosaminidase; AltName: Full=Alpha-galactosidase B; Flags: Precursor [Rattus norvegicus]