Gene/Proteome Database (LMPD)

LMPD ID
LMP013397
Gene ID
316033
Species
Rattus norvegicus (Rat)
Gene Name
galactosidase, beta 1
Gene Symbol
Glb1
Alternate Names
beta-galactosidase;
Chromosome
8
Map Location
8q32
EC Number
3.2.1.23
Summary
mutation of the human homolog causes GM1 gangliosidosis and Morquio B disease [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Glb1

Proteins

beta-galactosidase precursor
Refseq ID NP_001101662
Protein GI 157824103
UniProt ID D3ZUM4
mRNA ID NM_001108192
Length 647
MFRVPLCMLLPLLALLQLLGAAHSFYNVSQRTFELDYKRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLDAIQTYVPWNFHEPQPGQYDFSGDRDVEHFIQLAHQLGLLVILRPGPYICAEWDMGGLPAWLLEKESIVLRSSDPDYLAAVDKWLAVLLPKMKRLLYQNGGPIITVQVENEYGSYFACDYNYLRFLEHRFRYHLGNDIILFTTDGAAEKLLKCGTLQDLYATVDFGTTGNITRAFLIQRNFEPKGPLINSEFYTGWLDHWGQPHSKVNTKKLVASLYNLLAYGASVNLYMFIGGTNFAYWNGANMPYAPQPTSYDYDAPLSEAGDLTEKYFAVRDVIRKFKEVPEGPIPPSTPKFAYGKVALRKFKTVTEALGILCPNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPINGVRDRAYVSVDGVPQGILDRNRMNVLNIRGKAGATLDILVENMGRVNYGNSIKDFKGLISNMTLNFTVLTNWTMFPLDTEALARSHLGNWEAADEGHLDGHSTLRSSNFTLPTFYVGNFSIPSGIPDLPQDTFIQFPGWAKGQVWINGFNLGRYWPTKGPQMTLFVPRNILTTSAPNNITVLELESSPCSNGTLELCTVEFVDTPVIG
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2621 peptide sequence: MFRVPLCMLLPLLALLQLLGAAHS

Gene Information

Entrez Gene ID
316033
Gene Name
galactosidase, beta 1
Gene Symbol
Glb1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IDA:RGD C lysosome
GO:0004565 IDA:RGD F beta-galactosidase activity
GO:0016936 IDA:RGD F galactoside binding
GO:0019388 IDA:RGD P galactose catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00052 Galactose metabolism
rno00052 Galactose metabolism
ko00531 Glycosaminoglycan degradation
rno00531 Glycosaminoglycan degradation
ko00604 Glycosphingolipid biosynthesis - ganglio series
rno00604 Glycosphingolipid biosynthesis - ganglio series
M00079 Keratan sulfate degradation
ko04142 Lysosome
rno04142 Lysosome
rno01100 Metabolic pathways
ko00511 Other glycan degradation
rno00511 Other glycan degradation
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953739 Asparagine N-linked glycosylation
5953738 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5953253 Disease
5953252 Glycogen storage diseases
5953861 Glycosaminoglycan metabolism
5954485 Glycosphingolipid metabolism
5954498 HS-GAG degradation
5954347 Heparan sulfate/heparin (HS-GAG) metabolism
5954494 Keratan sulfate degradation
5954345 Keratan sulfate/keratin metabolism
5953870 MPS I - Hurler syndrome
5953869 MPS II - Hunter syndrome
5953872 MPS IIIA - Sanfilippo syndrome A
5953864 MPS IIIB - Sanfilippo syndrome B
5953867 MPS IIIC - Sanfilippo syndrome C
5953871 MPS IIID - Sanfilippo syndrome D
5953866 MPS IV - Morquio syndrome A
5953873 MPS IV - Morquio syndrome B
5953862 MPS IX - Natowicz syndrome
5953865 MPS VI - Maroteaux-Lamy syndrome
5953868 MPS VII - Sly syndrome
5953250 Metabolism
5953249 Metabolism of carbohydrates
5953289 Metabolism of lipids and lipoproteins
5953345 Metabolism of proteins
5953863 Mucopolysaccharidoses
5953251 Myoclonic epilepsy of Lafora
5953728 Post-translational protein modification
5954270 Sialic acid metabolism
5954267 Sphingolipid metabolism
5953737 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR026283 Beta-galactosidase 1-like
IPR008979 Galactose-binding domain-like
IPR017853 Glycoside hydrolase superfamily
IPR013781 Glycoside hydrolase, catalytic domain
IPR001944 Glycoside hydrolase, family 35
IPR019801 Glycoside hydrolase, family 35, conserved site

UniProt Annotations

Entry Information

Gene Name
galactosidase, beta 1
Protein Entry
D3ZUM4_RAT
UniProt ID
D3ZUM4
Species
Rat

Comments

Comment Type Description
Catalytic Activity Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides
Similarity Belongs to the glycosyl hydrolase 35 family

Identical and Related Proteins

Unique RefSeq proteins for LMP013397 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157824103 RefSeq NP_001101662 647 beta-galactosidase precursor

Identical Sequences to LMP013397 proteins

Reference Database Accession Length Protein Name
GI:157824103 GenBank EDL76992.1 647 galactosidase, beta 1 (mapped) [Rattus norvegicus]

Related Sequences to LMP013397 proteins

Reference Database Accession Length Protein Name
GI:157824103 DBBJ BAE42549.1 647 unnamed protein product [Mus musculus]
GI:157824103 GenBank AAA37293.1 647 beta-galactosidase [Mus musculus]
GI:157824103 GenBank EDL76992.1 647 galactosidase, beta 1 (mapped) [Rattus norvegicus]
GI:157824103 SwissProt P23780.1 647 RecName: Full=Beta-galactosidase; AltName: Full=Acid beta-galactosidase; Short=Lactase; Flags: Precursor [Mus musculus]