Gene/Proteome Database (LMPD)

LMPD ID
LMP013410
Gene ID
353229
Species
Rattus norvegicus (Rat)
Gene Name
sphingomyelin synthase 1
Gene Symbol
Sgms1
Synonyms
Mob; Tmem23;
Alternate Names
phosphatidylcholine:ceramide cholinephosphotransferase 1; mob-1; protein Mob; transmembrane protein 23;
Chromosome
1
Map Location
1q52
EC Number
2.7.8.27
Summary
alpha-chemokine; involved in inducing lung inflammation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Sgms1

Proteins

phosphatidylcholine:ceramide cholinephosphotransferase 1
Refseq ID NP_852051
Protein GI 78214321
UniProt ID Q7TSX5
mRNA ID NM_181386
Length 419
MLSASTMKEVVYWSPKKVADWLLENAMPEYCEPLGHFTGQDLINLTQEDFTKPPLCRVSSDNGQRLLDMIETLKMEHHIEAHKNGHANGHLSIGVDIPNPDGSFSIKIKPNGMPNGFRKEMIKIPMPEPERSQYPMEWGKTLLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLFQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQVRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPLPWPVVHLSRQVKYSRLVNDT

Gene Information

Entrez Gene ID
353229
Gene Name
sphingomyelin synthase 1
Gene Symbol
Sgms1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000138 IEA:Ensembl C Golgi trans cisterna
GO:0030173 ISS:UniProtKB C integral component of Golgi membrane
GO:0047493 ISS:UniProtKB F ceramide cholinephosphotransferase activity
GO:0016301 IEA:UniProtKB-KW F kinase activity
GO:0033188 ISS:HGNC F sphingomyelin synthase activity
GO:0006915 IEA:UniProtKB-KW P apoptotic process
GO:0016049 ISS:HGNC P cell growth
GO:0071222 IEP:RGD P cellular response to lipopolysaccharide
GO:0071356 IEP:RGD P cellular response to tumor necrosis factor
GO:0006954 IDA:RGD P inflammatory response
GO:2001237 IEA:Ensembl P negative regulation of extrinsic apoptotic signaling pathway
GO:0010628 IDA:RGD P positive regulation of gene expression
GO:0006686 ISS:HGNC P sphingomyelin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954266 Sphingolipid de novo biosynthesis
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR025749 Sphingomyelin synthase-like domain
IPR001660 Sterile alpha motif domain
IPR013761 Sterile alpha motif/pointed domain

UniProt Annotations

Entry Information

Gene Name
sphingomyelin synthase 1
Protein Entry
SMS1_RAT
UniProt ID
Q7TSX5
Species
Rat

Comments

Comment Type Description
Catalytic Activity A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide (By similarity)
Sequence Caution Sequence=AAP37281.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the sphingomyelin synthase family
Similarity Contains 1 SAM (sterile alpha motif) domain
Subcellular Location Golgi apparatus membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013410 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
78214321 RefSeq NP_852051 419 phosphatidylcholine:ceramide cholinephosphotransferase 1

Identical Sequences to LMP013410 proteins

Reference Database Accession Length Protein Name
GI:78214321 GenBank AAH81693.1 419 Sphingomyelin synthase 1 [Rattus norvegicus]
GI:78214321 GenBank EDM13135.1 419 transmembrane protein 23, isoform CRA_a [Rattus norvegicus]
GI:78214321 SwissProt Q7TSX5.2 419 RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1; AltName: Full=Protein Mob; AltName: Full=Sphingomyelin synthase 1; AltName: Full=Transmembrane protein 23 [Rattus norvegicus]

Related Sequences to LMP013410 proteins

Reference Database Accession Length Protein Name
GI:78214321 GenBank AAP37281.1 413 MOB protein [Rattus norvegicus]
GI:78214321 GenBank AAH81693.1 419 Sphingomyelin synthase 1 [Rattus norvegicus]
GI:78214321 GenBank EDM13135.1 419 transmembrane protein 23, isoform CRA_a [Rattus norvegicus]
GI:78214321 SwissProt Q7TSX5.2 419 RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1; AltName: Full=Protein Mob; AltName: Full=Sphingomyelin synthase 1; AltName: Full=Transmembrane protein 23 [Rattus norvegicus]