Gene/Proteome Database (LMPD)

LMPD ID
LMP013416
Gene ID
360420
Species
Rattus norvegicus (Rat)
Gene Name
retinol dehydrogenase 7
Gene Symbol
Rdh7
Synonyms
Rdh3; RoDH(III); RGD1307178;
Alternate Names
retinol dehydrogenase 7; RODH I; RODH III; retinol dehydrogenase 3; retinol dehydrogenase type III; hypothetical gene supported by NM_133543;
Chromosome
7
Map Location
7q22
EC Number
1.1.1.105
Summary
catalyzes the first step in retinoic acid biogenesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Rdh7

Proteins

retinol dehydrogenase 7 precursor
Refseq ID NP_598227
Protein GI 58585242
UniProt ID P55006
mRNA ID NM_133543
Length 317
MWLYLLALVGLWNLLRLFRERKVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEQLRSKTSDRLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGISVPMGPNEWMRKKDFASVLDVNLLGVIEVTLNMLPLVRKARGRVVNIASTMGRMSLLGGGYCISKYGVEAFSDSLRRELTYFGVKVAIIEPGGFKTNVTNMERLSDNLKKLWDQATEEVKEIYGEKFRDSYMKAMESLVNMCSGDLSLVTDCMEHALTSCHPRTRYSAGWDAKFFYLPMSYLPTFLSDAVIYWGSVKPARAL
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2088 peptide sequence: MWLYLLALVGLWNLLRL

Gene Information

Entrez Gene ID
360420
Gene Name
retinol dehydrogenase 7
Gene Symbol
Rdh7
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0004745 IEA:UniProtKB-EC F retinol dehydrogenase activity
GO:0042572 IEA:UniProtKB-UniPathway P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00830 Retinol metabolism
rno00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
retinol dehydrogenase 7
Protein Entry
RDH7_RAT
UniProt ID
P55006
Species
Rat

Comments

Comment Type Description
Catalytic Activity All-trans-retinol-[cellular-retinol-binding- protein] + NAD(+) = all-trans-retinal-[cellular-retinol-binding- protein] + NADH.
Function Acts on retinol bound on cellular retinol-binding protein (CRBP).
Pathway Cofactor metabolism; retinol metabolism.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular Location Microsome. Endoplasmic reticulum .

Identical and Related Proteins

Unique RefSeq proteins for LMP013416 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58585242 RefSeq NP_598227 317 retinol dehydrogenase 7 precursor

Identical Sequences to LMP013416 proteins

Reference Database Accession Length Protein Name
GI:58585242 GenBank AAH88090.1 317 Retinol dehydrogenase 7 [Rattus norvegicus]
GI:58585242 GenBank AAH98650.1 317 Retinol dehydrogenase 7 [Rattus norvegicus]
GI:58585242 GenBank EDM16445.1 317 rCG60224 [Rattus norvegicus]
GI:58585242 SwissProt P55006.1 317 RecName: Full=Retinol dehydrogenase 7; AltName: Full=Retinol dehydrogenase type III; Short=RODH III [Rattus norvegicus]

Related Sequences to LMP013416 proteins

Reference Database Accession Length Protein Name
GI:58585242 GenBank AAH88090.1 317 Retinol dehydrogenase 7 [Rattus norvegicus]
GI:58585242 GenBank AAH98650.1 317 Retinol dehydrogenase 7 [Rattus norvegicus]
GI:58585242 GenBank EDM16445.1 317 rCG60224 [Rattus norvegicus]
GI:58585242 SwissProt P55006.1 317 RecName: Full=Retinol dehydrogenase 7; AltName: Full=Retinol dehydrogenase type III; Short=RODH III [Rattus norvegicus]