Gene/Proteome Database (LMPD)

LMPD ID
LMP013417
Gene ID
360426
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A2, group VI (cytosolic, calcium-independent)
Gene Symbol
Pla2g6
Synonyms
iPla2; PNPLA9;
Alternate Names
85/88 kDa calcium-independent phospholipase A2; GVI PLA2; caI-PLA2; iPLA2-beta; group VI phospholipase A2; 85 kDa calcium-independent phospholipase A2; patatin-like phospholipase domain-containing protein 9; intracellular membrane-associated calcium-independent phospholipase A2 beta;
Chromosome
7
Map Location
7q34
EC Number
3.1.1.4
Summary
has Ca2+ independent phospholipase A2 activity; may play a role in regulating transmembrane ionic fluxes in pancreatic beta cells [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pla2g6

Proteins

85/88 kDa calcium-independent phospholipase A2 isoform 1
Refseq ID NP_001005560
Protein GI 53850648
UniProt ID P97570
mRNA ID NM_001005560
Length 807
MQFFGRLVNTLSSVTNLFSNPFRVKEVSLADYASSERVREEGQLILLQNASNRTWDCVLVSPRNPQSGFRLFQLESEADALVNFQQYSSQLPPFYESSVQVLHVEVLQHLTDLIRNHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNPQVLQLLGKNASAGLNQVNNQGLTPLHLACQMGKQEMVRVLLLCNARCNIMGPGGFPIHTAMKFSQKGCAEMIISMDSNQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSASGNTALHVAVTRNRFDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPAFIASKISKLITRKALLTLLKTVGADYHFPFIQGVSTEQSSAAGPHPFFSLDRTQPPTISLNNLELQDLMPVSRARKPAFILSSMRDEKRSHDHLLCLDGGGVKGLVIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEAVREPRCTPNINLKPPTQPADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDMIRKGQGNKVKKLSIVVSLGTGKSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGSDIMLDEVSDAVLVNALWETEVYIYEHREEFQKLVQLLLSP
85/88 kDa calcium-independent phospholipase A2 isoform 2
Refseq ID NP_001257725
Protein GI 399124808
UniProt ID P97570
mRNA ID NM_001270796
Length 752
MQFFGRLVNTLSSVTNLFSNPFRVKEVSLADYASSERVREEGQLILLQNASNRTWDCVLVSPRNPQSGFRLFQLESEADALVNFQQYSSQLPPFYESSVQVLHVEVLQHLTDLIRNHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNPQVLQLLGKNASAGLNQVNNQGLTPLHLACQMGKQEMVRVLLLCNARCNIMGPGGFPIHTAMKFSQKGCAEMIISMDSNQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSASGNTALHVAVTRNRFDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPAFIASKISKQLQDLMPVSRARKPAFILSSMRDEKRSHDHLLCLDGGGVKGLVIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEAVREPRCTPNINLKPPTQPADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDMIRKGQGNKVKKLSIVVSLGTGKSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGSDIMLDEVSDAVLVNALWETEVYIYEHREEFQKLVQLLLSP

Gene Information

Entrez Gene ID
360426
Gene Name
phospholipase A2, group VI (cytosolic, calcium-independent)
Gene Symbol
Pla2g6
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0005743 TAS:Reactome C mitochondrial inner membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0043008 IDA:RGD F ATP-dependent protein binding
GO:0047499 IDA:RGD F calcium-independent phospholipase A2 activity
GO:0032049 IEA:Ensembl P cardiolipin biosynthetic process
GO:0006935 IEA:UniProtKB-KW P chemotaxis
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0060135 IEP:RGD P maternal process involved in female pregnancy
GO:0007613 IMP:RGD P memory
GO:0051967 IMP:RGD P negative regulation of synaptic transmission, glutamatergic
GO:0090238 IMP:RGD P positive regulation of arachidonic acid secretion
GO:2000304 IDA:RGD P positive regulation of ceramide biosynthetic process
GO:0007204 IMP:RGD P positive regulation of cytosolic calcium ion concentration
GO:0045921 IMP:RGD P positive regulation of exocytosis
GO:0035774 IDA:RGD P positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0090037 IMP:RGD P positive regulation of protein kinase C signaling
GO:0001934 IDA:RGD P positive regulation of protein phosphorylation
GO:0090200 IDA:RGD P positive regulation of release of cytochrome c from mitochondria
GO:0045909 IMP:RGD P positive regulation of vasodilation
GO:1901339 IMP:RGD P regulation of store-operated calcium channel activity
GO:0034976 IDA:RGD P response to endoplasmic reticulum stress
GO:0014832 IMP:RGD P urinary bladder smooth muscle contraction

KEGG Pathway Links

KEGG Pathway ID Description
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
ko00565 Ether lipid metabolism
rno00565 Ether lipid metabolism
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko00591 Linoleic acid metabolism
rno00591 Linoleic acid metabolism
rno01100 Metabolic pathways
rno04014 Ras signaling pathway
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954472 Acyl chain remodeling of CL
5954464 Acyl chain remodelling of PC
5954471 Acyl chain remodelling of PE
5953784 Fcgamma receptor (FCGR) dependent phagocytosis
5953473 Glycerophospholipid biosynthesis
5953410 Immune System
5953409 Innate Immune System
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5953783 Role of phospholipids in phagocytosis

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR002641 Patatin/Phospholipase A2-related

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group VI (cytosolic, calcium-independent)
Protein Entry
PLPL9_RAT
UniProt ID
P97570
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P97570-1; Sequence=Displayed; Name=Short; IsoId=P97570-2; Sequence=VSP_044365;
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Enzyme Regulation Inhibited by calcium-activated calmodulin
Function Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods (By similarity)
Similarity Contains 1 patatin domain
Similarity Contains 7 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular Location Isoform Long: Membrane ; Peripheral membrane protein. Note=Recruited to the membrane- enriched pseudopod upon MCP1/CCL2 stimulation in monocytes
Subcellular Location Isoform Short: Cytoplasm .
Tissue Specificity Found in brain, lung, spleen, kidney, liver, heart and skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP013417 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
53850648 RefSeq NP_001005560 807 85/88 kDa calcium-independent phospholipase A2 isoform 1
399124808 RefSeq NP_001257725 752 85/88 kDa calcium-independent phospholipase A2 isoform 2

Identical Sequences to LMP013417 proteins

Reference Database Accession Length Protein Name
GI:53850648 GenBank AAH81916.1 807 Phospholipase A2, group VI (cytosolic, calcium-independent) [Rattus norvegicus]
GI:399124808 GenBank EDM15809.1 752 phospholipase A2, group VI, isoform CRA_a [Rattus norvegicus]
GI:53850648 GenBank AEU43314.1 807 Sequence 63 from patent US 8052970
GI:399124808 GenBank AEU43408.1 752 Sequence 157 from patent US 8052970
GI:399124808 GenBank AEU43409.1 752 Sequence 158 from patent US 8052970
GI:53850648 GenBank AEU43438.1 807 Sequence 187 from patent US 8052970
GI:399124808 RefSeq XP_006242068.1 752 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X1 [Rattus norvegicus]
GI:53850648 SwissProt P97570.2 807 RecName: Full=85/88 kDa calcium-independent phospholipase A2; Short=CaI-PLA2; AltName: Full=Group VI phospholipase A2; Short=GVI PLA2; AltName: Full=Intracellular membrane-associated calcium-independent phospholipase A2 beta; Short=iPLA2-beta; AltName: Full=Patatin-like phospholipase domain-containing protein 9; Short=PNPLA9 [Rattus norvegicus]

Related Sequences to LMP013417 proteins

Reference Database Accession Length Protein Name
GI:53850648 GenBank AAH81916.1 807 Phospholipase A2, group VI (cytosolic, calcium-independent) [Rattus norvegicus]
GI:399124808 GenBank EDM15809.1 752 phospholipase A2, group VI, isoform CRA_a [Rattus norvegicus]
GI:53850648 GenBank AEU43314.1 807 Sequence 63 from patent US 8052970
GI:399124808 GenBank AEU43408.1 752 Sequence 157 from patent US 8052970
GI:399124808 GenBank AEU43409.1 752 Sequence 158 from patent US 8052970
GI:53850648 GenBank AEU43438.1 807 Sequence 187 from patent US 8052970
GI:399124808 RefSeq XP_006242068.1 752 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X1 [Rattus norvegicus]
GI:53850648 SwissProt P97570.2 807 RecName: Full=85/88 kDa calcium-independent phospholipase A2; Short=CaI-PLA2; AltName: Full=Group VI phospholipase A2; Short=GVI PLA2; AltName: Full=Intracellular membrane-associated calcium-independent phospholipase A2 beta; Short=iPLA2-beta; AltName: Full=Patatin-like phospholipase domain-containing protein 9; Short=PNPLA9 [Rattus norvegicus]