Gene/Proteome Database (LMPD)
Proteins
metallophosphoesterase 1 | |
---|---|
Refseq ID | NP_001101905 |
Protein GI | 157823043 |
UniProt ID | B1WC86 |
mRNA ID | NM_001108435 |
Length | 394 |
MALVRWGLRRQNFHLLRRRRVLLLKLTVVVISVLLFCEYFIYYLVLFRCHWPEVKMPARGGRQEPVLKAMFLADTHLLGEIRGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDVFDEGKWSSAQAWADDLHRFQRMFRHGSHVQLKVVIGNHDIGFHYQMSKYRINRFEKVFGSERLFSLKGVNFVMVNSVAMEGDGCTICSEAEAELREISRKLNCSQEQVQGSSQCDHEPRLPLSAPVLLQHYPLYRASDANCSGEDAAPPEERSVPFEEKYDVLSREASQKLLWWLRPRLILSGHTHSACEVLHPGGAPEVSVPSFSWRNRNNPSFIMGSLTSRDYALSKCYLPCEDTVLTTYCAAAAFLLVLILAHFERLPSSFLFGWKLCRSHLRR |
Gene Information
Entrez Gene ID
Gene Name
metallophosphoesterase 1
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005801 | ISS:UniProtKB | C | cis-Golgi network |
GO:0070971 | ISS:UniProtKB | C | endoplasmic reticulum exit site |
GO:0005793 | ISS:UniProtKB | C | endoplasmic reticulum-Golgi intermediate compartment |
GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0034235 | ISS:UniProtKB | F | GPI anchor binding |
GO:0030145 | ISS:UniProtKB | F | manganese ion binding |
GO:0008081 | ISS:UniProtKB | F | phosphoric diester hydrolase activity |
GO:0006888 | ISS:UniProtKB | P | ER to Golgi vesicle-mediated transport |
GO:0006506 | ISS:UniProtKB | P | GPI anchor biosynthetic process |
Domain Information
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Cofactor | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ; |
Function | Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity) |
Similarity | Belongs to the metallophosphoesterase superfamily. MPPE1 family |
Subcellular Location | Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein . Note=Also localizes to endoplasmic reticulum exit site |
Subunit | Interacts with GPI-anchor proteins. Interacts with TMED10 (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP013434 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
157823043 | RefSeq | NP_001101905 | 394 | metallophosphoesterase 1 |
Identical Sequences to LMP013434 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:157823043 | GenBank | EDM14719.1 | 394 | metallophosphoesterase 1 (predicted), isoform CRA_b [Rattus norvegicus] |
GI:157823043 | GenBank | AAI62043.1 | 394 | Metallophosphoesterase 1 [Rattus norvegicus] |
GI:157823043 | RefSeq | XP_006254941.1 | 394 | PREDICTED: metallophosphoesterase 1 isoform X1 [Rattus norvegicus] |
GI:157823043 | SwissProt | B1WC86.1 | 394 | RecName: Full=Metallophosphoesterase 1; AltName: Full=Post-GPI attachment to proteins factor 5 [Rattus norvegicus] |
Related Sequences to LMP013434 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:157823043 | GenBank | EDM14719.1 | 394 | metallophosphoesterase 1 (predicted), isoform CRA_b [Rattus norvegicus] |
GI:157823043 | GenBank | AAI62043.1 | 394 | Metallophosphoesterase 1 [Rattus norvegicus] |
GI:157823043 | RefSeq | XP_006254941.1 | 394 | PREDICTED: metallophosphoesterase 1 isoform X1 [Rattus norvegicus] |
GI:157823043 | SwissProt | B1WC86.1 | 394 | RecName: Full=Metallophosphoesterase 1; AltName: Full=Post-GPI attachment to proteins factor 5 [Rattus norvegicus] |