Gene/Proteome Database (LMPD)

LMPD ID
LMP013434
Gene ID
361344
Species
Rattus norvegicus (Rat)
Gene Name
metallophosphoesterase 1
Gene Symbol
Mppe1
Alternate Names
metallophosphoesterase 1; post-GPI attachment to proteins factor 5;
Chromosome
18
Map Location
18q12.1
EC Number
3.1.-.-

Proteins

metallophosphoesterase 1
Refseq ID NP_001101905
Protein GI 157823043
UniProt ID B1WC86
mRNA ID NM_001108435
Length 394
MALVRWGLRRQNFHLLRRRRVLLLKLTVVVISVLLFCEYFIYYLVLFRCHWPEVKMPARGGRQEPVLKAMFLADTHLLGEIRGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDVFDEGKWSSAQAWADDLHRFQRMFRHGSHVQLKVVIGNHDIGFHYQMSKYRINRFEKVFGSERLFSLKGVNFVMVNSVAMEGDGCTICSEAEAELREISRKLNCSQEQVQGSSQCDHEPRLPLSAPVLLQHYPLYRASDANCSGEDAAPPEERSVPFEEKYDVLSREASQKLLWWLRPRLILSGHTHSACEVLHPGGAPEVSVPSFSWRNRNNPSFIMGSLTSRDYALSKCYLPCEDTVLTTYCAAAAFLLVLILAHFERLPSSFLFGWKLCRSHLRR

Gene Information

Entrez Gene ID
361344
Gene Name
metallophosphoesterase 1
Gene Symbol
Mppe1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005801 ISS:UniProtKB C cis-Golgi network
GO:0070971 ISS:UniProtKB C endoplasmic reticulum exit site
GO:0005793 ISS:UniProtKB C endoplasmic reticulum-Golgi intermediate compartment
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034235 ISS:UniProtKB F GPI anchor binding
GO:0030145 ISS:UniProtKB F manganese ion binding
GO:0008081 ISS:UniProtKB F phosphoric diester hydrolase activity
GO:0006888 ISS:UniProtKB P ER to Golgi vesicle-mediated transport
GO:0006506 ISS:UniProtKB P GPI anchor biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like

UniProt Annotations

Entry Information

Gene Name
metallophosphoesterase 1
Protein Entry
MPPE1_RAT
UniProt ID
B1WC86
Species
Rat

Comments

Comment Type Description
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
Function Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity)
Similarity Belongs to the metallophosphoesterase superfamily. MPPE1 family
Subcellular Location Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Multi-pass membrane protein . Note=Also localizes to endoplasmic reticulum exit site
Subunit Interacts with GPI-anchor proteins. Interacts with TMED10 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013434 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157823043 RefSeq NP_001101905 394 metallophosphoesterase 1

Identical Sequences to LMP013434 proteins

Reference Database Accession Length Protein Name
GI:157823043 GenBank EDM14719.1 394 metallophosphoesterase 1 (predicted), isoform CRA_b [Rattus norvegicus]
GI:157823043 GenBank AAI62043.1 394 Metallophosphoesterase 1 [Rattus norvegicus]
GI:157823043 RefSeq XP_006254941.1 394 PREDICTED: metallophosphoesterase 1 isoform X1 [Rattus norvegicus]
GI:157823043 SwissProt B1WC86.1 394 RecName: Full=Metallophosphoesterase 1; AltName: Full=Post-GPI attachment to proteins factor 5 [Rattus norvegicus]

Related Sequences to LMP013434 proteins

Reference Database Accession Length Protein Name
GI:157823043 GenBank EDM14719.1 394 metallophosphoesterase 1 (predicted), isoform CRA_b [Rattus norvegicus]
GI:157823043 GenBank AAI62043.1 394 Metallophosphoesterase 1 [Rattus norvegicus]
GI:157823043 RefSeq XP_006254941.1 394 PREDICTED: metallophosphoesterase 1 isoform X1 [Rattus norvegicus]
GI:157823043 SwissProt B1WC86.1 394 RecName: Full=Metallophosphoesterase 1; AltName: Full=Post-GPI attachment to proteins factor 5 [Rattus norvegicus]