Gene/Proteome Database (LMPD)

LMPD ID
LMP013436
Gene ID
361401
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A2, group XV
Gene Symbol
Pla2g15
Synonyms
ACS; LLPL; LPLA2; Lypla3; 1-O-acylceramidesynthase;
Alternate Names
group XV phospholipase A2; ACS {ECO:0000303|PubMed:15294901}; LLPL {ECO:0000250|UniProtKB:Q8VEB4}; LPLA2 {ECO:0000303|PubMed:15294901}; lysophospholipase 3 {ECO:0000250|UniProtKB:Q8VEB4}; 1-O-acylceramide synthase {ECO:0000303|PubMed:15294901}; group XV phospholipase A2 {ECO:0000312|EMBL:AAH98894.1}; LCAT-like lysophospholipase {ECO:0000250|UniProtKB:Q8VEB4}; pla2g15 {ECO:0000312|Ensembl:ENSRNOP00000026996, ECO:0000312|RGD:1302982}; lysosomal phospholipase A2 {ECO:0000303|PubMed:15294901, ECO:0000312|EMBL:AAS66767.1};
Chromosome
19
Map Location
19q12
EC Number
2.3.1.-
Summary
displays calcium independent phospholipase activity toward phosphatidylcholine and phosphatidylethanolamine; may play a role in degradation of pulmonary surfactant phospholipids [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pla2g15

Proteins

group XV phospholipase A2 precursor
Refseq ID NP_001004277
Protein GI 51948522
UniProt ID Q675A5
mRNA ID NM_001004277
Length 413
MDRHLCICREIQLRSGLLFPFLLLMMLADLALPAQRHPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKRTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRTTQFPDGVDVRVPGFGETFSLEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALQEMIEEMYQMYGGPVVLVAHSMGNMYMLYFLQRQPQAWKDKYIQAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTWSHEKVFVYTPTANYTLRDYHRFFQDIGFEDGWFMRQDTQGLVEALVPPGVELHCLYGTGVPTPNSFYYENFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHKVSLQELPGSEHIEMLANATTLAYLKRVLLEEP
sig_peptide: 1..33 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3844 peptide sequence: MDRHLCICREIQLRSGLLFPFLLLMMLADLALP

Gene Information

Entrez Gene ID
361401
Gene Name
phospholipase A2, group XV
Gene Symbol
Pla2g15
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 ISS:UniProtKB C lysosome
GO:0005739 IEA:Ensembl C mitochondrion
GO:0008374 IDA:UniProtKB F O-acyltransferase activity
GO:0047499 IDA:RGD F calcium-independent phospholipase A2 activity
GO:0006672 IEA:Ensembl P ceramide metabolic process
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0046470 IMP:RGD P phosphatidylcholine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
ko04142 Lysosome
rno04142 Lysosome

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group XV
Protein Entry
PAG15_RAT
UniProt ID
Q675A5
Species
Rat

Comments

Comment Type Description
Biophysicochemical Properties pH dependence: Optimum pH is 4.5. ;
Enzyme Regulation Transacylase activity is inhibited by MJ33
Function Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid
Ptm N-glycosylated
Similarity Belongs to the AB hydrolase superfamily. Lipase family
Subcellular Location Secreted {ECO:0000250|UniProtKB:Q8NCC3, ECO:0000250|UniProtKB:Q8VEB4}. Lysosome .
Tissue Specificity Widely expressed. Expressed at highest levels in alveolar macrophages

Identical and Related Proteins

Unique RefSeq proteins for LMP013436 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51948522 RefSeq NP_001004277 413 group XV phospholipase A2 precursor

Identical Sequences to LMP013436 proteins

Reference Database Accession Length Protein Name
GI:51948522 GenBank AAH98894.1 413 Phospholipase A2, group XV [Rattus norvegicus]
GI:51948522 GenBank EDL92440.1 413 rCG51420, isoform CRA_b [Rattus norvegicus]
GI:51948522 GenBank AEU43524.1 413 Sequence 273 from patent US 8052970
GI:51948522 SwissProt Q675A5.1 413 RecName: Full=Group XV phospholipase A2; AltName: Full=1-O-acylceramide synthase; Short=ACS; AltName: Full=LCAT-like lysophospholipase; Short=LLPL; AltName: Full=Lysophospholipase 3; AltName: Full=Lysosomal phospholipase A2; Short=LPLA2; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013436 proteins

Reference Database Accession Length Protein Name
GI:51948522 GenBank AAS66767.1 413 lysosomal phospholipase A2 [Rattus norvegicus]
GI:51948522 GenBank AAH98894.1 413 Phospholipase A2, group XV [Rattus norvegicus]
GI:51948522 GenBank EDL92440.1 413 rCG51420, isoform CRA_b [Rattus norvegicus]
GI:51948522 GenBank AEU43524.1 413 Sequence 273 from patent US 8052970