Gene/Proteome Database (LMPD)

LMPD ID
LMP013440
Gene ID
361465
Species
Rattus norvegicus (Rat)
Gene Name
ethylmalonyl-CoA decarboxylase 1
Gene Symbol
Echdc1
Synonyms
MMCD;
Alternate Names
ethylmalonyl-CoA decarboxylase; methylmalonyl-CoA decarboxylase; enoyl CoA hydratase domain containing 1; enoyl Coenzyme A hydratase domain containing 1; enoyl-CoA hydratase domain-containing protein 1;
Chromosome
1
Map Location
1p11
EC Number
4.1.1.94

Proteins

ethylmalonyl-CoA decarboxylase
Refseq ID NP_001007735
Protein GI 56090598
UniProt ID Q6AYG5
mRNA ID NM_001007734
Length 299
MAKSLLASSLSVRTKILQTGVSLYNTTHGFHEEEVKKILEQFPGGSIDLQKKQNGIGILTLNNSNKMNAFSGAMMLQLLERVIELENWTEGKGLIVHGAKNTFCSGSDLNAVKALSTPENGVALSMFMQNTLTRFMRLPLISVALVQGWAMGGGAELTTACDFRLMTEESVIRFVHKEMGIVPSWGGASRLVEIIGSRQALKVLSGTFKLDSKEALRIGLADEVLQPSDEATALEQAQEWLEQFVSGPAQVIRGLKKSVCSGRELYLEEALQNERDVLETLWGGPANLEAIAKKGKHTK

Gene Information

Entrez Gene ID
361465
Gene Name
ethylmalonyl-CoA decarboxylase 1
Gene Symbol
Echdc1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:UniProtKB C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016831 ISS:UniProtKB F carboxy-lyase activity
GO:0004492 IEA:UniProtKB-EC F methylmalonyl-CoA decarboxylase activity

KEGG Pathway Links

KEGG Pathway ID Description
ko00640 Propanoate metabolism
rno00640 Propanoate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
ethylmalonyl-CoA decarboxylase 1
Protein Entry
ECHD1_RAT
UniProt ID
Q6AYG5
Species
Rat

Comments

Comment Type Description
Catalytic Activity (S)-ethylmalonyl-CoA = butanoyl-CoA + CO(2).
Catalytic Activity (S)-methylmalonyl-CoA = propanoyl-CoA + CO(2).
Function Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity)
Similarity Belongs to the enoyl-CoA hydratase/isomerase family
Subcellular Location Cytoplasm, cytosol .

Identical and Related Proteins

Unique RefSeq proteins for LMP013440 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
56090598 RefSeq NP_001007735 299 ethylmalonyl-CoA decarboxylase

Identical Sequences to LMP013440 proteins

Reference Database Accession Length Protein Name
GI:56090598 GenBank EDL87693.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Rattus norvegicus]
GI:56090598 GenBank EDL87694.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Rattus norvegicus]
GI:56090598 GenBank EDL87695.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Rattus norvegicus]
GI:56090598 RefSeq XP_006227809.1 299 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X1 [Rattus norvegicus]

Related Sequences to LMP013440 proteins

Reference Database Accession Length Protein Name
GI:56090598 GenBank AAH79052.1 299 Enoyl Coenzyme A hydratase domain containing 1 [Rattus norvegicus]
GI:56090598 GenBank EDL87693.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Rattus norvegicus]
GI:56090598 GenBank EDL87694.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Rattus norvegicus]
GI:56090598 RefSeq XP_006227809.1 299 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X1 [Rattus norvegicus]