Gene/Proteome Database (LMPD)

LMPD ID
LMP013445
Gene ID
361632
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Gene Symbol
Pik3c2a
Alternate Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphoinositide-3-kinase, class 2, alpha polypeptide; phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha;
Chromosome
1
Map Location
1q34-q35

Proteins

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Refseq ID NP_001101970
Protein GI 157817478
UniProt ID D3ZTF6
mRNA ID NM_001108500
Length 1687
MAQISNNSEFKQCSSSHPEPIRTKDVDKAEALQMEAEALAKLQKDRHMTDSPRGFELSNSTRQRTQGFNKQDYDLMVFPESDSQKRALDIDVEKLTQAELEKILLDDNFETRKTPASPVTPVLSPSFSAQLYLRPAVQRSQWPPGLCGPSTYTLPSIYPSAYSKQATFQNGFSPRMPTFPSTESIYLRLPGQSPYFSYPLTPATPFHPQGSLPVYRPLVSPDMAKLFDKIASTSEFLKNGKARTDLEIANSKASVCNLQISPKSEDINKFDWLDLDPLSKPKIDCVEVLEHEEEKKNPVLLAEDPWDAVLLEERSPTSRHLERKVNGKSLSGATVTRSQSLIVRTTQVTKAQSQVSQKDPNGTSSLATGSSLLQEFEVQNEEVAAFCQSIMKLKTKFPYTDHCTNPGYLLSPVTVQRNMCGENASVKVSIEIEGFQQPVTFTCDVSSTVDIIIMQALCWVHDDLNQVDVGSYILKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIKLQLLTFSAMCQNLARTAEDDEAPVDLNKYLYQIEKPYKEVMTRHPVEELLDSYHYQVELALQTENQHRAIDQVIKAVRKICSALDGVETPAVTEAVKKLKRAVNLPRNKSADVTSLSGGDTSKNSTRGSLNLENPVQVSMDHLTAAIYDLLRLHTNSCKSSTVCPQGSRNIKEAWTATEQLQFTVYAAHGISSNWVSNYEKYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGVLNQSSGSSPDSNKQRKGPEALGKVSLTLFDFKRFLTCGTKLLYLWTSSHTNSIPGAIPQKSYVMERIVLQVDFPSPAFDIIYTSPQIDRNIIQQYKLEALENEIKGKLLDIVHRDSSFGLSKEDKAFLWEKRYYCLKHPNCLPKILASAPNWKWANLAKTYSLLHQWPPLCPLAALELLDAKFADQEVRSLAVSWIEAISDDELTDLLPQFVQALKYEIYLNSSLVRFLLSRALGNIQIAHSLYWLLKDALHDTRFGSRYEHVLGALLSVGGKGLREELSKQMKLVQLLGGVAEKVRQASGSARQVVLQKSMERVQSFFLRNKCRVPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDQGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGHLEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSTGTSPFSPTLGQIGGAVKLSVSYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDTHKTSKRKTKISRKTRNPTFNEMLVYSGYSRETLRQRELQLSVLSAESLRENFFLGGITLPLKDFNLSKETVKWYQLTAATYL

Gene Information

Entrez Gene ID
361632
Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Gene Symbol
Pik3c2a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005942 IBA:RefGenome C phosphatidylinositol 3-kinase complex
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0031982 ISS:UniProtKB C vesicle
GO:0016303 IBA:RefGenome F 1-phosphatidylinositol-3-kinase activity
GO:0035005 IBA:RefGenome F 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0006897 ISS:UniProtKB P endocytosis
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5954103 Clathrin derived vesicle budding
5954251 Golgi Associated Vesicle Biogenesis
5953916 Membrane Trafficking
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954478 PI Metabolism
5953474 Phospholipid metabolism
5954502 Synthesis of PIPs at the Golgi membrane
5954503 Synthesis of PIPs at the early endosome membrane
5954500 Synthesis of PIPs at the late endosome membrane
5954499 Synthesis of PIPs at the plasma membrane
5954104 trans-Golgi Network Vesicle Budding

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR001683 Phox homologous domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Protein Entry
D3ZTF6_RAT
UniProt ID
D3ZTF6
Species
Rat

Comments

Comment Type Description
Similarity Contains 1 C2 domain
Similarity Contains PI3K/PI4K domain
Similarity Contains PIK helical domain

Identical and Related Proteins

Unique RefSeq proteins for LMP013445 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157817478 RefSeq NP_001101970 1687 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Identical Sequences to LMP013445 proteins

Reference Database Accession Length Protein Name
GI:157817478 GenBank EDM17731.1 1687 phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted), isoform CRA_a [Rattus norvegicus]
GI:157817478 RefSeq XP_008757992.1 1687 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [Rattus norvegicus]

Related Sequences to LMP013445 proteins

Reference Database Accession Length Protein Name
GI:157817478 GenBank EDM17731.1 1687 phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (predicted), isoform CRA_a [Rattus norvegicus]
GI:157817478 RefSeq NP_035213.2 1686 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Mus musculus]
GI:157817478 RefSeq XP_008757992.1 1687 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [Rattus norvegicus]
GI:157817478 SwissProt Q61194.2 1686 RecName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Short=PI3K-C2-alpha; Short=PtdIns-3-kinase C2 subunit alpha; AltName: Full=Cpk-m; AltName: Full=Phosphoinositide 3-kinase-C2-alpha; AltName: Full=p170 [Mus musculus]