Gene/Proteome Database (LMPD)

LMPD ID
LMP013450
Gene ID
361676
Species
Rattus norvegicus (Rat)
Gene Name
patatin-like phospholipase domain containing 2
Gene Symbol
Pnpla2
Synonyms
RGD1309044;
Alternate Names
patatin-like phospholipase domain-containing protein 2; adipose triglyceride lipase;
Chromosome
1
Map Location
1q41
EC Number
3.1.1.3

Proteins

patatin-like phospholipase domain-containing protein 2
Refseq ID NP_001101979
Protein GI 189095277
UniProt ID P0C548
mRNA ID NM_001108509
Length 478
MFPRETKWNISFAGCGFLGVYHIGVASCLREHAPFLVANATHIYGASAGALTATALVTGACLGEAGANIIEVSKEARKRFLGPLHPSFNLVKTIRGCLLKTLPADCHTRASGRLGISLTRVSDGENVIISHFSSKDELIQANVCSTFIPVYCGLIPPTLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRITNTSIQFNLRNLYRLSKALFPPEPMVLREMCKQGYRDGLRFLRRNGLLNQPNPLLALPPVVPQEEDAEEAAVTEERTGGEDRILEHLPARLNEALLEACVEPKDLMTTLSNMLPVRLATAMMVPYTLPLESAVSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGDHLPSRLSEQVELRRAQSLPSVPLSCATYSEALPNWVRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPDALRMRAPASPTATDPATPQDPSGLPPC

Gene Information

Entrez Gene ID
361676
Gene Name
patatin-like phospholipase domain containing 2
Gene Symbol
Pnpla2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IEA:UniProtKB-KW C lipid particle
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004806 ISS:UniProtKB F triglyceride lipase activity
GO:0010891 ISS:UniProtKB P negative regulation of sequestering of triglyceride
GO:0010898 ISS:UniProtKB P positive regulation of triglyceride catabolic process
GO:0019433 IEA:UniProtKB-UniPathway P triglyceride catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00098 Acylglycerol degradation
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5954466 Acyl chain remodeling of DAG and TAG
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002641 Patatin/Phospholipase A2-related

UniProt Annotations

Entry Information

Gene Name
patatin-like phospholipase domain containing 2
Protein Entry
PLPL2_RAT
UniProt ID
P0C548
Species
Rat

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Function Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity)
Induction Increased by rosiglitazone in subcutaneous and visceral white adipose tissue
Pathway Glycerolipid metabolism; triacylglycerol degradation.
Ptm May be phosphorylated
Ptm Phosphorylation at Ser-398 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity
Similarity Contains 1 patatin domain
Subcellular Location Lipid droplet . Cell membrane {ECO:0000250}; Single-pass type II membrane protein .
Subunit Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity (By similarity). Interacts with SERPINF1; interacts at one site of interaction (By similarity). Despite a colocalization in lipid droplets, it probably does not interact with PLIN (By similarity). Interacts with PLIN5; prevents interaction with ABHD5. {ECO:0000250, ECO:0000269|PubMed:23408028, ECO:0000269|PubMed:24303154}.

Identical and Related Proteins

Unique RefSeq proteins for LMP013450 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189095277 RefSeq NP_001101979 478 patatin-like phospholipase domain-containing protein 2

Identical Sequences to LMP013450 proteins

Reference Database Accession Length Protein Name
GI:189095277 GenBank EDM12062.1 478 patatin-like phospholipase domain containing 2 (predicted), isoform CRA_b [Rattus norvegicus]
GI:189095277 RefSeq XP_003749062.1 478 PREDICTED: patatin-like phospholipase domain-containing protein 2 [Rattus norvegicus]
GI:189095277 SwissProt P0C548.1 478 RecName: Full=Patatin-like phospholipase domain-containing protein 2; AltName: Full=Adipose triglyceride lipase [Rattus norvegicus]

Related Sequences to LMP013450 proteins

Reference Database Accession Length Protein Name
GI:189095277 GenBank EDM12062.1 478 patatin-like phospholipase domain containing 2 (predicted), isoform CRA_b [Rattus norvegicus]
GI:189095277 RefSeq XP_003749062.1 478 PREDICTED: patatin-like phospholipase domain-containing protein 2 [Rattus norvegicus]
GI:189095277 SwissProt Q8BJ56.1 486 RecName: Full=Patatin-like phospholipase domain-containing protein 2; AltName: Full=Adipose triglyceride lipase; AltName: Full=Desnutrin [Mus musculus]
GI:189095277 SwissProt P0C548.1 478 RecName: Full=Patatin-like phospholipase domain-containing protein 2; AltName: Full=Adipose triglyceride lipase [Rattus norvegicus]