Gene/Proteome Database (LMPD)
LMPD ID
LMP013453
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol transfer protein, membrane-associated 1
Gene Symbol
Synonyms
Pitpnm;
Alternate Names
membrane-associated phosphatidylinositol transfer protein 1; NIR-2; PITPnm 1; phosphatidylinositol membrane-associated; pyk2 N-terminal domain-interacting receptor 2;
Chromosome
1
Map Location
1q42
Proteins
| membrane-associated phosphatidylinositol transfer protein 1 | |
|---|---|
| Refseq ID | NP_001008370 |
| Protein GI | 56605814 |
| UniProt ID | Q5U2N3 |
| mRNA ID | NM_001008369 |
| Length | 1242 |
| MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGNGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPRLYRSVKTGRGPLADDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWIELSMADIRALEEETARMLAQRMAKCNTGSEGPEAQTPGKPSTETQPGTRTAGTPDGPEAPPGPDASPDASFGKQWSSSSRSSYSSQHGGGVSPQSLSEWRMQNIARDSENSSEEEFFDAHEGFSDSDEVFPKEMTKWNSNDFIDAFASPTEVEGVPDPAIMATKGIEDEARAPRDSEGLDGTGDLGVEACSVHALFLILHSGSILDSGPGDTNSKQADVQTLSTAFEAVTRVHFPEALGHVALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLLATSSSRYQGAVATVIARTNQAYAAFLRSSEGTGFCGQVVLIGDGVGGILGFDALCHSASAGTGSRGSSRRGSMNNEMLSPEVGPVRDPLADGVEVLGRASPEPSALPAQRTSSDMANPDPDGSQNSLQVAPTVTSGEPRRASTASCPPASSEAPDGPTNAARLDFKVSGFFLFGSPLGLVLALRKTVMPALEVAQMRPACEQIYNLFHAADPCASRLEPLLAPKFQAIAPLAVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMMVPSTPTSASGAFWKGNELGNEPAAQPAAPSTTSEVVKILDRWWGNKRIDYSLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQLTECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRPQVLNGRFMYGPLDVVTLTGEKVDVYVMTQPLSGKWIHFGTEVTNSSGRLTFPVPSERALGIGVYPVRMVVRGDHTYAECCLTVVSRGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHAPSGPPRAALAKSSYAVAAPVDFLRKQSQLLRSRGPSQVDLEGPGTPPTTLARGKTRSISLKLDSEE | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol transfer protein, membrane-associated 1
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0005811 | IEA:UniProtKB-KW | C | lipid particle |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0015031 | IEA:UniProtKB-KW | P | protein transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol transfer protein, membrane-associated 1
Protein Entry
PITM1_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Function | Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions (By similarity) |
| Ptm | Phosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1 (By similarity) |
| Ptm | Phosphorylated on threonine residues upon treatment with oleic acid |
| Ptm | Phosphorylated on tyrosine residues by PTK2B |
| Similarity | Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily |
| Similarity | Contains 1 DDHD domain. {ECO:0000255|PROSITE- ProRule:PRU00378}. |
| Subcellular Location | Cytoplasm . Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane ; Peripheral membrane protein . Lipid droplet {ECO:0000250}. Cleavage furrow . Midbody . Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (By similarity) |
| Subunit | Interacts with PIK4CA and VAPB. Interacts with PTK2B via its C-terminus. Interacts with RHOA. Has higher affinity for the inactive, GDP-bound form of RHOA. The CDK1-phosphorylated form interacts with PLK1 (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP013453 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 56605814 | RefSeq | NP_001008370 | 1242 | membrane-associated phosphatidylinositol transfer protein 1 |
Identical Sequences to LMP013453 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:56605814 | GenBank | AAH85945.1 | 1242 | Phosphatidylinositol transfer protein, membrane-associated 1 [Rattus norvegicus] |
| GI:56605814 | GenBank | EDM12363.1 | 1242 | phosphatidylinositol transfer protein, membrane-associated 1, isoform CRA_a [Rattus norvegicus] |
| GI:56605814 | GenBank | EDM12364.1 | 1242 | phosphatidylinositol transfer protein, membrane-associated 1, isoform CRA_a [Rattus norvegicus] |
| GI:56605814 | SwissProt | Q5U2N3.1 | 1242 | RecName: Full=Membrane-associated phosphatidylinositol transfer protein 1; AltName: Full=Phosphatidylinositol transfer protein, membrane-associated 1; Short=PITPnm 1; AltName: Full=Pyk2 N-terminal domain-interacting receptor 2; Short=NIR-2 [Rattus norvegicus] |
Related Sequences to LMP013453 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:56605814 | GenBank | AAH85945.1 | 1242 | Phosphatidylinositol transfer protein, membrane-associated 1 [Rattus norvegicus] |
| GI:56605814 | GenBank | EDM12363.1 | 1242 | phosphatidylinositol transfer protein, membrane-associated 1, isoform CRA_a [Rattus norvegicus] |
| GI:56605814 | GenBank | EDM12364.1 | 1242 | phosphatidylinositol transfer protein, membrane-associated 1, isoform CRA_a [Rattus norvegicus] |
| GI:56605814 | SwissProt | Q5U2N3.1 | 1242 | RecName: Full=Membrane-associated phosphatidylinositol transfer protein 1; AltName: Full=Phosphatidylinositol transfer protein, membrane-associated 1; Short=PITPnm 1; AltName: Full=Pyk2 N-terminal domain-interacting receptor 2; Short=NIR-2 [Rattus norvegicus] |