Gene/Proteome Database (LMPD)

LMPD ID
LMP013458
Gene ID
361801
Species
Rattus norvegicus (Rat)
Gene Name
retinoid X receptor beta
Gene Symbol
Rxrb
Synonyms
RXR-beta;
Alternate Names
retinoic acid receptor RXR-beta; retinoic acid receptor, beta; nuclear receptor coregulator 1; nuclear receptor co-regulator 1; nuclear receptor subfamily 2 group B member 2;
Chromosome
20
Map Location
20p12
Summary
forms a dimer with the retinoic acid receptor and other nuclear receptors; enhances retinoic acid receptor, thyroid hormone receptor, and vitamin D receptor transcriptional regulation activities [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Rxrb

Proteins

retinoic acid receptor RXR-beta
Refseq ID NP_996731
Protein GI 77404367
mRNA ID NM_206849
Length 518
MSWATRPPFLPPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAGEQQTLEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLSQGIPPSSPPGPPHTPSAPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA

Gene Information

Entrez Gene ID
361801
Gene Name
retinoid X receptor beta
Gene Symbol
Rxrb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004886 IDA:RGD F 9-cis retinoic acid receptor activity
GO:0046982 IDA:RGD F protein heterodimerization activity
GO:0042974 IDA:RGD F retinoic acid receptor binding
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0046966 IDA:RGD F thyroid hormone receptor binding
GO:0030375 IDA:RGD F thyroid hormone receptor coactivator activity
GO:0042809 IDA:RGD F vitamin D receptor binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:2000273 IDA:GOC P positive regulation of receptor activity
GO:0031641 IDA:RGD P regulation of myelination
GO:0048384 IDA:GOC P retinoic acid receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko04920 Adipocytokine signaling pathway
rno04920 Adipocytokine signaling pathway
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
rno05200 Pathways in cancer
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko05216 Thyroid cancer
rno05216 Thyroid cancer
rno04919 Thyroid hormone signaling pathway
ko05202 Transcriptional misregulation in cancer
rno05202 Transcriptional misregulation in cancer

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR000003 Retinoid X receptor/HNF4
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoid X receptor beta
Species
Rat

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).
Sequence Caution Sequence=AAA42025.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.

Identical and Related Proteins

Unique RefSeq proteins for LMP013458 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
77404367 RefSeq NP_996731 518 retinoic acid receptor RXR-beta

Identical Sequences to LMP013458 proteins

Reference Database Accession Length Protein Name
GI:77404367 GenBank EDL96823.1 518 rCG60716 [Rattus norvegicus]

Related Sequences to LMP013458 proteins

Reference Database Accession Length Protein Name
GI:77404367 DBBJ BAA04858.1 520 RXR-beta1 isoform [Mus musculus]
GI:77404367 GenBank EDL96823.1 518 rCG60716 [Rattus norvegicus]
GI:77404367 RefSeq XP_005360472.1 517 PREDICTED: retinoic acid receptor RXR-beta isoform X2 [Microtus ochrogaster]
GI:77404367 RefSeq XP_006256022.1 689 PREDICTED: retinoic acid receptor RXR-beta isoform X1 [Rattus norvegicus]