Gene/Proteome Database (LMPD)

LMPD ID
LMP013474
Gene ID
362434
Species
Rattus norvegicus (Rat)
Gene Name
lysophosphatidylcholine acyltransferase 3
Gene Symbol
Lpcat3
Synonyms
Oact5; Grcc3f; Mboat5;
Alternate Names
lysophospholipid acyltransferase 5; LPLAT 5; gene rich cluster, C3f; lyso-PC acyltransferase 3; 1-acylglycerophosphocholine O-acyltransferase; O-acyltransferase domain-containing protein 5; membrane bound O-acyltransferase domain containing 5; O-acyltransferase (membrane bound) domain containing 5; membrane-bound O-acyltransferase domain-containing protein 5;
Chromosome
4
Map Location
4q42
EC Number
2.3.1.-

Proteins

lysophospholipid acyltransferase 5
Refseq ID NP_001012189
Protein GI 58865950
UniProt ID Q5FVN0
mRNA ID NM_001012189
Length 487
MASTADGDVGETLGQMRGLWPGVEDLSLNKLATSLGASEQALRLIFSIFLGYPLALFYRHYLFYKDSYLIHLFHAFSGLSIAYFNFGHQFYHSLLCVVLQFLILRLMGRTITAVFTTLCFQMAYLLAGYYYTATGDYDIKWTMPHCVLTLKLIGLSIDYYDGGKDRNSLSSEQQKYAILGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVKGQLTDVPGKMPNSTIPALKRLSLGLVYLVGYTLLSPHITEDYLLTEDYDTRPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILSGLGFNGFEENGTVKWDACANMKVWLFETTPRFTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLICFQMEFLIVIVEKQATNLIRDSPALSSLASITALQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYRSIYFLGHVFFLSLLFTLPYVYKAMVPRKEKLKKRE

Gene Information

Entrez Gene ID
362434
Gene Name
lysophosphatidylcholine acyltransferase 3
Gene Symbol
Lpcat3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0047184 IEA:UniProtKB-EC F 1-acylglycerophosphocholine O-acyltransferase activity
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process
GO:0097006 IEA:Ensembl P regulation of plasma lipoprotein particle levels

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954464 Acyl chain remodelling of PC
5954471 Acyl chain remodelling of PE
5954470 Acyl chain remodelling of PS
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT

UniProt Annotations

Entry Information

Gene Name
lysophosphatidylcholine acyltransferase 3
Protein Entry
MBOA5_RAT
UniProt ID
Q5FVN0
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
Domain The di-lysine motif confers endoplasmic reticulum localization
Function Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity)
Pathway Lipid metabolism; phospholipid metabolism.
Similarity Belongs to the membrane-bound acyltransferase family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013474 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865950 RefSeq NP_001012189 487 lysophospholipid acyltransferase 5

Identical Sequences to LMP013474 proteins

Reference Database Accession Length Protein Name
GI:58865950 GenBank AAH89869.1 487 Lysophosphatidylcholine acyltransferase 3 [Rattus norvegicus]
GI:58865950 GenBank EDM01950.1 487 rCG29915 [Rattus norvegicus]
GI:58865950 SwissProt Q5FVN0.1 487 RecName: Full=Lysophospholipid acyltransferase 5; Short=LPLAT 5; AltName: Full=1-acylglycerophosphocholine O-acyltransferase; AltName: Full=Lysophosphatidylcholine acyltransferase 3; Short=Lyso-PC acyltransferase 3; AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 5; Short=O-acyltransferase domain-containing protein 5 [Rattus norvegicus]

Related Sequences to LMP013474 proteins

Reference Database Accession Length Protein Name
GI:58865950 GenBank AAH06753.2 487 Lysophosphatidylcholine acyltransferase 3 [Mus musculus]
GI:58865950 GenBank AAH89869.1 487 Lysophosphatidylcholine acyltransferase 3 [Rattus norvegicus]
GI:58865950 GenBank EDM01950.1 487 rCG29915 [Rattus norvegicus]
GI:58865950 SwissProt Q5FVN0.1 487 RecName: Full=Lysophospholipid acyltransferase 5; Short=LPLAT 5; AltName: Full=1-acylglycerophosphocholine O-acyltransferase; AltName: Full=Lysophosphatidylcholine acyltransferase 3; Short=Lyso-PC acyltransferase 3; AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 5; Short=O-acyltransferase domain-containing protein 5 [Rattus norvegicus]