Gene/Proteome Database (LMPD)
LMPD ID
LMP013478
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
ALG6, alpha-1,3-glucosyltransferase
Gene Symbol
Alternate Names
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; asparagine-linked glycosylation protein 6 homolog; dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase; dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog; asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase); asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase);
Chromosome
5
Map Location
5q33
EC Number
2.4.1.267
Proteins
| dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor | |
|---|---|
| Refseq ID | NP_001028881 |
| Protein GI | 76096358 |
| UniProt ID | Q3T1L5 |
| mRNA ID | NM_001033709 |
| Length | 507 |
| MESWTWMTVVVLLGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHWQEITLNLPVKQWYFNSSDNNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWVALHTSRGYESQAHKLFMRTTVLAADLLIYIPAVLLYCYSLKEISPKRKIASALCILLYPGLILIDYGHFQYNSVSLGFALWGVLGVSCDWDLLGSLAFCLALNYKQMELYHSLPFFCFLLGKCFKKGLRGKGSALFIRIACTVVASFLLCWLPFLTEREHALQVVRRLFPVDRGLFEDKVANIWCSLNVFLKIKDILPRHIQIAISFCFTFLSLLPACIKLTVQPSAKGFRFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLTEIPFMSTWFLLVSTFSMLPLLLKDQLLLPSVVTVMAFLIACSTFFPMFENTSEEQLQLKSFAVSVRRHLPGFTFLPRIIQCLFLSSVITMILLTILSVTLDPPQKLPDLFSVLICFVSCVNFVFFLVYFNIVIMWDSKNGRNRKKID | |
| sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2595 peptide sequence: MESWTWMTVVVLLGLTVRWTVS | |
Gene Information
Entrez Gene ID
Gene Name
ALG6, alpha-1,3-glucosyltransferase
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | IEA:InterPro | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016758 | IEA:InterPro | F | transferase activity, transferring hexosyl groups |
| GO:0006486 | IEA:UniProtKB-UniPathway | P | protein glycosylation |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR004856 | Glycosyl transferase, ALG6/ALG8 |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Dolichyl beta-D-glucosyl phosphate + D-Man- alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha- (1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))- D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D- GlcNAc-diphosphodolichol = D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)- D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man- alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha- (1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc- diphosphodolichol + dolichyl phosphate. |
| Function | Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity) |
| Pathway | Protein modification; protein glycosylation. |
| Similarity | Belongs to the ALG6/ALG8 glucosyltransferase family |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein . |
Identical and Related Proteins
Unique RefSeq proteins for LMP013478 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 76096358 | RefSeq | NP_001028881 | 507 | dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor |
Identical Sequences to LMP013478 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:76096358 | GenBank | AAI01851.1 | 507 | Asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) [Rattus norvegicus] |
| GI:76096358 | SwissProt | Q3T1L5.1 | 507 | RecName: Full=Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; AltName: Full=Asparagine-linked glycosylation protein 6 homolog; AltName: Full=Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; AltName: Full=Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase [Rattus norvegicus] |
Related Sequences to LMP013478 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:76096358 | DBBJ | BAE42720.1 | 507 | unnamed protein product [Mus musculus] |
| GI:76096358 | GenBank | AAI01851.1 | 507 | Asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) [Rattus norvegicus] |
| GI:76096358 | RefSeq | NP_001074733.1 | 507 | dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor [Mus musculus] |
| GI:76096358 | SwissProt | Q3T1L5.1 | 507 | RecName: Full=Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; AltName: Full=Asparagine-linked glycosylation protein 6 homolog; AltName: Full=Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; AltName: Full=Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase [Rattus norvegicus] |