Gene/Proteome Database (LMPD)

LMPD ID
LMP013484
Gene ID
362676
Species
Rattus norvegicus (Rat)
Gene Name
family with sequence similarity 213, member B
Gene Symbol
Fam213b
Synonyms
RGD1308251;
Alternate Names
prostamide/prostaglandin F synthase; prostamide/PGF synthase; prostamide/PG F synthase;
Chromosome
5
Map Location
5q36
EC Number
1.11.1.20;

Proteins

prostamide/prostaglandin F synthase
Refseq ID NP_001102167
Protein GI 157822867
UniProt ID D3ZVR7
mRNA ID NM_001108697
Length 201
MSTLDLGRVGACVLKHAVTGEAVELRSLWQEKACVVAGLRRFGCMVCRWIAQDLSNLRGILDQNDVRLVGIGPEALGLQEFLDGGYFSGELYLDESKQIYKELGFKRYNSLSILPAALGKPVRDVASKAKAVGIQGNLSGDLLQSGGLLVVSKGGDRVLLHFIQSSPGDYVPQENILQALGISAEVCSSKPPQCDEEVCGR

Gene Information

Entrez Gene ID
362676
Gene Name
family with sequence similarity 213, member B
Gene Symbol
Fam213b
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProt C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0005783 ISS:UniProt C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0043209 IDA:UniProt C myelin sheath
GO:0016616 ISS:UniProtKB F oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047017 ISS:UniProt F prostaglandin-F synthase activity
GO:0001516 ISS:UniProtKB P prostaglandin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953493 Arachidonic acid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953492 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Domain Information

InterPro Annotations

Accession Description
IPR012336 Thioredoxin-like fold

UniProt Annotations

Entry Information

Gene Name
family with sequence similarity 213, member B
Protein Entry
PGFS_RAT
UniProt ID
D3ZVR7
Species
Rat

Comments

Comment Type Description
Catalytic Activity Thioredoxin + prostaglandin H(2) = thioredoxin disulfide + prostaglandin F(2-alpha).
Function Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity)
Similarity Belongs to the peroxiredoxin-like FAM213 family. Prostamide/prostaglandin F synthase subfamily
Subcellular Location Cytoplasm, cytosol .

Identical and Related Proteins

Unique RefSeq proteins for LMP013484 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157822867 RefSeq NP_001102167 201 prostamide/prostaglandin F synthase

Identical Sequences to LMP013484 proteins

Reference Database Accession Length Protein Name
GI:157822867 GenBank EDL81278.1 201 similar to RIKEN cDNA 2810405K02 (predicted) [Rattus norvegicus]
GI:157822867 SwissProt D3ZVR7.1 201 RecName: Full=Prostamide/prostaglandin F synthase; Short=Prostamide/PG F synthase; Short=Prostamide/PGF synthase [Rattus norvegicus]

Related Sequences to LMP013484 proteins

Reference Database Accession Length Protein Name
GI:157822867 GenBank AAH30453.1 201 RIKEN cDNA 2810405K02 gene [Mus musculus]
GI:157822867 GenBank EDL81278.1 201 similar to RIKEN cDNA 2810405K02 (predicted) [Rattus norvegicus]
GI:157822867 SwissProt Q9DB60.1 201 RecName: Full=Prostamide/prostaglandin F synthase; Short=Prostamide/PG F synthase; Short=Prostamide/PGF synthase [Mus musculus]
GI:157822867 SwissProt D3ZVR7.1 201 RecName: Full=Prostamide/prostaglandin F synthase; Short=Prostamide/PG F synthase; Short=Prostamide/PGF synthase [Rattus norvegicus]