Gene/Proteome Database (LMPD)
Proteins
| free fatty acid receptor 3 | |
|---|---|
| Refseq ID | NP_001102382 |
| Protein GI | 157817578 |
| UniProt ID | B2GV46 |
| mRNA ID | NM_001108912 |
| Length | 319 |
| MDTSFFPGNHWLFFSVDLLVFLVGLPLNVMALVVFVNKLRRRPVAVDLLLLNLTISDLLLLLFLPFRIVEAACGMKWILPFIFCPLSGFLFFTTIYLTSLFLMTVSIERFLSVAYPLWYKTRPRLAQAGLVSGICWFLASAHCSVIYVTEYWGNATYSQGTNGTCYLEFREDQLAILLPVRLEMAVVLFMVPLCITSYCYSRLVWILSQGASRRRRKRVMGLLVATLLIFFVCFGPYNMSHVVGYVRGESPTWRSYVLLLSTLNSCIDPLVFYFSSSKFQADFHQLLSRLIRACVPWTQEVSLELKVKNGEEPSKECPS | |
Gene Information
Entrez Gene ID
Gene Name
free fatty acid receptor 3
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | ISS:UniProtKB | C | plasma membrane |
| GO:0004930 | IDA:UniProtKB | F | G-protein coupled receptor activity |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0007193 | ISS:UniProtKB | P | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
| GO:0071398 | IDA:UniProtKB | P | cellular response to fatty acid |
| GO:0007186 | IDA:UniProtKB | P | G-protein coupled receptor signaling pathway |
| GO:0006954 | IEA:UniProtKB-KW | P | inflammatory response |
| GO:0002385 | ISS:UniProtKB | P | mucosal immune response |
| GO:0045776 | ISS:UniProtKB | P | negative regulation of blood pressure |
| GO:0045760 | IEA:Ensembl | P | positive regulation of action potential |
| GO:0002879 | ISS:UniProtKB | P | positive regulation of acute inflammatory response to non-antigenic stimulus |
| GO:0032722 | ISS:UniProtKB | P | positive regulation of chemokine production |
| GO:0002720 | ISS:UniProtKB | P | positive regulation of cytokine production involved in immune response |
| GO:2001275 | ISS:UniProtKB | P | positive regulation of glucose import in response to insulin stimulus |
| GO:0003062 | IEA:Ensembl | P | regulation of heart rate by chemical signal |
| GO:0046885 | ISS:UniProtKB | P | regulation of hormone biosynthetic process |
| GO:0014061 | ISS:UniProtKB | P | regulation of norepinephrine secretion |
| GO:0090276 | ISS:UniProtKB | P | regulation of peptide hormone secretion |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954122 | Class A/1 (Rhodopsin-like receptors) |
| 5954300 | Free fatty acid receptors |
| 5953653 | G alpha (q) signalling events |
| 5953537 | Gastrin-CREB signalling pathway via PKC and MAPK |
| 5953642 | GPCR downstream signaling |
| 5953758 | GPCR ligand binding |
| 5953391 | Signaling by GPCR |
| 5953381 | Signal Transduction |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases (PubMed:24305827). Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis (PubMed:24412651). May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:24305827, ECO:0000269|PubMed:24412651}. |
| Similarity | Belongs to the G-protein coupled receptor 1 family |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Expressed in the sympathetic nervous system |
Identical and Related Proteins
Unique RefSeq proteins for LMP013520 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 157817578 | RefSeq | NP_001102382 | 319 | free fatty acid receptor 3 |
Identical Sequences to LMP013520 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157817578 | EMBL | CAC69578.1 | 319 | unnamed protein product [Rattus sp.] |
| GI:157817578 | GenBank | EDM07705.1 | 319 | G protein-coupled receptor 41 (predicted) [Rattus norvegicus] |
| GI:157817578 | GenBank | AAI66522.1 | 319 | Free fatty acid receptor 3 [Rattus norvegicus] |
| GI:157817578 | SwissProt | B2GV46.1 | 319 | RecName: Full=Free fatty acid receptor 3; AltName: Full=G-protein coupled receptor 41 [Rattus norvegicus] |
Related Sequences to LMP013520 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157817578 | EMBL | CAC69578.1 | 319 | unnamed protein product [Rattus sp.] |
| GI:157817578 | GenBank | EDM07705.1 | 319 | G protein-coupled receptor 41 (predicted) [Rattus norvegicus] |
| GI:157817578 | GenBank | AAI66522.1 | 319 | Free fatty acid receptor 3 [Rattus norvegicus] |
| GI:157817578 | SwissProt | B2GV46.1 | 319 | RecName: Full=Free fatty acid receptor 3; AltName: Full=G-protein coupled receptor 41 [Rattus norvegicus] |