Gene/Proteome Database (LMPD)
LMPD ID
LMP013531
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
Gene Symbol
Synonyms
Pip5k1b;
Alternate Names
phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; PIP5KIalpha; PIP5K1-alpha; ptdIns(4)P-5-kinase 1 alpha; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha;
Chromosome
2
Map Location
2q34
Proteins
| phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | |
|---|---|
| Refseq ID | NP_001036086 |
| Protein GI | 110835721 |
| mRNA ID | NM_001042621 |
| Length | 546 |
| MASASSGPAAAGFSPLDSGVPAGTAASGIKRGTVSEGPYASLMPVKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELSNSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHMKYDLKGSTYKRRASQKEREKTLPTFKDLDFLQDIPDGLFLDADMYSALCKTLQRDCLVLQSFKIMDYSLLMSIHNMDHAQREPMNSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTVETEDHMGGIPARNNKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPTKKFRSGPSFSRRSGPSGNSCTPSQPTASGEHKAQVTTKAEVEPDIHLGRPDVLPQTPPLEEISEGSPVPGPSFSPAVGQPLQILNLSSTLEKLDVAESELTH | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0030027 | IEA:Ensembl | C | lamellipodium |
| GO:0005847 | IEA:Ensembl | C | mRNA cleavage and polyadenylation specificity factor complex |
| GO:0016607 | IEA:Ensembl | C | nuclear speck |
| GO:0032587 | IEA:Ensembl | C | ruffle membrane |
| GO:0016308 | IEA:UniProtKB-EC | F | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0031532 | IEA:Ensembl | P | actin cytoskeleton reorganization |
| GO:0032863 | IEA:Ensembl | P | activation of Rac GTPase activity |
| GO:0060326 | IEA:Ensembl | P | cell chemotaxis |
| GO:0010761 | IEA:Ensembl | P | fibroblast migration |
| GO:0048041 | IEA:Ensembl | P | focal adhesion assembly |
| GO:0008654 | IEA:Ensembl | P | phospholipid biosynthetic process |
| GO:0072661 | IEA:Ensembl | P | protein targeting to plasma membrane |
| GO:0097178 | IEA:Ensembl | P | ruffle assembly |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04144 | Endocytosis |
| rno04144 | Endocytosis |
| ko04666 | Fc gamma R-mediated phagocytosis |
| rno04666 | Fc gamma R-mediated phagocytosis |
| ko00562 | Inositol phosphate metabolism |
| rno00562 | Inositol phosphate metabolism |
| M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
| rno01100 | Metabolic pathways |
| ko04070 | Phosphatidylinositol signaling system |
| rno04070 | Phosphatidylinositol signaling system |
| ko04810 | Regulation of actin cytoskeleton |
| rno04810 | Regulation of actin cytoskeleton |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR023610 | Phosphatidylinositol-4-phosphate 5-kinase |
| IPR027483 | Phosphatidylinositol-4-phosphate 5-kinase, C-terminal |
| IPR027484 | Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain |
| IPR002498 | Phosphatidylinositol-4-phosphate 5-kinase, core |
| IPR016034 | Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| Function | Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where it acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (By similarity). {ECO:0000250}. |
| Similarity | Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}. |
| Subcellular Location | Cell membrane {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm. Cell projection, ruffle {ECO:0000250}. |
| Subunit | Interacts with RAC1. Interacts with TUT1. Forms a complex with CDH1/E-cadherin, CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP013531 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 110835721 | RefSeq | NP_001036086 | 546 | phosphatidylinositol 4-phosphate 5-kinase type-1 alpha |
Identical Sequences to LMP013531 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP013531 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:110835721 | DBBJ | BAE34344.1 | 546 | unnamed protein product [Mus musculus] |
| GI:110835721 | GenBank | AAH31774.1 | 546 | Phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha [Mus musculus] |
| GI:110835721 | RefSeq | XP_008759537.1 | 548 | PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [Rattus norvegicus] |
| GI:110835721 | SwissProt | D3ZSI8.1 | 546 | RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; Short=PIP5K1-alpha; Short=PtdIns(4)P-5-kinase 1 alpha; AltName: Full=68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Short=PIP5KIalpha [Rattus norvegicus] |