Gene/Proteome Database (LMPD)

LMPD ID
LMP013537
Gene ID
366463
Species
Rattus norvegicus (Rat)
Gene Name
3-oxoacid CoA transferase 2A
Gene Symbol
Oxct2a
Alternate Names
succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; SCOT-t1; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; testis-specific succinyl CoA:3-oxoacid CoA-transferase 1; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; succinyl-CoA:3-ketoacid-coenzyme A transferase 2A, mitochondrial;
Chromosome
5
Map Location
5q36
EC Number
2.8.3.5

Proteins

succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor
Refseq ID NP_001012221
Protein GI 58866010
UniProt ID Q5XIJ9
mRNA ID NM_001012221
Length 520
MAALRLLAWAFSRRVSAHRPQPTLPHHLIRHYPTTRCGKVKFYTDPVKAVEGIKDGASVMLGGFGLCGIPENLIGALKTKGVKDLKIISSNVGVDDFGLGILLASKQVRRVVCSYLGENKLCEQLYLAGKLELEMTPQGTLAERIRAGGTGVPAFYTPTGYGTQVQEGGVPIRYSPEGHLITLSQPREVREFEGQHHLLERAIRADFALIKGWKADRSGNVIFRGSARNFNVPMCKAADISVVEVEEIVDVGTFAPEDIHIPNIYVKRVIKGPRFEKRIERLTTRDSPPAPGSKDQDPKRTRIIKRAALEFKDGMYANLGIGIPVLASNYISPKMTVYLHSENGILGLGPFPLKKEVDPDIINAGKQTVTVIPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMVPGKKVKGMGGAMDLVSSKKTKVVVTMEHCTKTKQPKILEKCTMPLTGKSCVDLIITEKAVFEVDRSKGLKLVELWEGSSLDEVKATTGCSFKVCPNLKPMQQIKSDA
transit_peptide: 1..39 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q5XIJ9.1) calculated_mol_wt: 4547 peptide sequence: MAALRLLAWAFSRRVSAHRPQPTLPHHLIRHYPTTRCGK mat_peptide: 40..520 product: Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q5XIJ9.1) calculated_mol_wt: 52371 peptide sequence: VKFYTDPVKAVEGIKDGASVMLGGFGLCGIPENLIGALKTKGVKDLKIISSNVGVDDFGLGILLASKQVRRVVCSYLGENKLCEQLYLAGKLELEMTPQGTLAERIRAGGTGVPAFYTPTGYGTQVQEGGVPIRYSPEGHLITLSQPREVREFEGQHHLLERAIRADFALIKGWKADRSGNVIFRGSARNFNVPMCKAADISVVEVEEIVDVGTFAPEDIHIPNIYVKRVIKGPRFEKRIERLTTRDSPPAPGSKDQDPKRTRIIKRAALEFKDGMYANLGIGIPVLASNYISPKMTVYLHSENGILGLGPFPLKKEVDPDIINAGKQTVTVIPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMVPGKKVKGMGGAMDLVSSKKTKVVVTMEHCTKTKQPKILEKCTMPLTGKSCVDLIITEKAVFEVDRSKGLKLVELWEGSSLDEVKATTGCSFKVCPNLKPMQQIKSDA

Gene Information

Entrez Gene ID
366463
Gene Name
3-oxoacid CoA transferase 2A
Gene Symbol
Oxct2a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0008260 IEA:UniProtKB-EC F 3-oxoacid CoA-transferase activity
GO:0046952 IEA:InterPro P ketone body catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
ko00072 Synthesis and degradation of ketone bodies
rno00072 Synthesis and degradation of ketone bodies
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

Domain Information

InterPro Annotations

Accession Description
IPR014388 3-oxoacid_CoA-transferase
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR004164 Coenzyme A transferase active site
IPR004163 Coenzyme A transferase binding site
IPR004165 Coenzyme A transferase family I

UniProt Annotations

Entry Information

Gene Name
3-oxoacid CoA transferase 2A
Protein Entry
SCO2A_RAT
UniProt ID
Q5XIJ9
Species
Rat

Comments

Comment Type Description
Catalytic Activity Succinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA
Function Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa (By similarity)
Pathway Ketone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA: step 1/1.
Similarity Belongs to the 3-oxoacid CoA-transferase family
Subcellular Location Mitochondrion .
Subunit Homodimer
Tissue Specificity Expressed in flagella of epididymal sperm

Identical and Related Proteins

Unique RefSeq proteins for LMP013537 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58866010 RefSeq NP_001012221 520 succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor

Identical Sequences to LMP013537 proteins

Reference Database Accession Length Protein Name
GI:58866010 GenBank AAH83681.1 520 3-oxoacid CoA transferase 2A [Rattus norvegicus]
GI:58866010 SwissProt Q5XIJ9.1 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 2A; AltName: Full=Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; Short=SCOT-t1; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013537 proteins

Reference Database Accession Length Protein Name
GI:58866010 GenBank AAH83681.1 520 3-oxoacid CoA transferase 2A [Rattus norvegicus]
GI:58866010 GenBank EDL80379.1 520 rCG31267 [Rattus norvegicus]
GI:58866010 RefSeq XP_008762334.1 552 PREDICTED: succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial [Rattus norvegicus]
GI:58866010 SwissProt Q5XIJ9.1 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 2A; AltName: Full=Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; Short=SCOT-t1; Flags: Precursor [Rattus norvegicus]