Gene/Proteome Database (LMPD)

LMPD ID
LMP013555
Gene ID
432367
Species
Rattus norvegicus (Rat)
Gene Name
NPC1-like 1
Gene Symbol
Npc1l1
Alternate Names
Niemann-Pick C1-like protein 1; Niemann-Pick disease, type C1-like 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1;
Chromosome
14
Map Location
chromosome:14
Summary
mouse homolog plays a role in intestinal cholesterol absorption [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Npc1l1

Proteins

Niemann-Pick C1-like protein 1 precursor
Refseq ID NP_001002025
Protein GI 50300485
UniProt ID Q6T3U3
mRNA ID NM_001002025
Length 1331
MAAAWLGWLLWALLLSAAQGELYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNTPARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNFVSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYESCSQVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKIAPCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALIIIFTAVFVLLSAVLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPHTILGRFFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSYKYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNTSLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLALSCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKEMESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRVAVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPFLLHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLASEAAVAPEPSCPQYPSPADADANVNYGFAPELAHGANAARSSLPKSDQKF
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2143 peptide sequence: MAAAWLGWLLWALLLSAAQG mat_peptide: 21..1331 product: Niemann-Pick C1-like protein 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6T3U3.1) calculated_mol_wt: 144292 peptide sequence: ELYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSNTPARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDNFVSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYESCSQVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGKIAPCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALIIIFTAVFVLLSAVLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPHTILGRFFQNWGTRVASWPLTVLALSFIVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSYKYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYNTSLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLALSCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKEMESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRVAVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAIILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPFLLHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLSSDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLASEAAVAPEPSCPQYPSPADADANVNYGFAPELAHGANAARSSLPKSDQKF

Gene Information

Entrez Gene ID
432367
Gene Name
NPC1-like 1
Gene Symbol
Npc1l1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031526 IDA:RGD C brush border membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008144 IDA:RGD F drug binding
GO:0008158 IEA:InterPro F hedgehog receptor activity
GO:0006695 IEA:Ensembl P cholesterol biosynthetic process
GO:0030299 IEA:Ensembl P intestinal cholesterol absorption
GO:0042157 IEA:Ensembl P lipoprotein metabolic process
GO:0042493 IEP:RGD P response to drug

KEGG Pathway Links

KEGG Pathway ID Description
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption

REACTOME Pathway Links

REACTOME Pathway ID Description
5953754 Lipid digestion, mobilization, and transport
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954097 Trafficking of dietary sterols

Domain Information

InterPro Annotations

Accession Description
IPR004765 Niemann-Pick C type protein
IPR003392 Patched
IPR000731 Sterol-sensing domain

UniProt Annotations

Entry Information

Gene Name
NPC1-like 1
Protein Entry
NPCL1_RAT
UniProt ID
Q6T3U3
Species
Rat

Comments

Comment Type Description
Function Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption (By similarity). Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity)
Ptm Highly glycosylated.
Similarity Belongs to the patched family
Similarity Contains 1 SSD (sterol-sensing) domain
Subcellular Location Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein.
Subunit Interacts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion (By similarity). Interacts with NPC2 (By similarity)
Tissue Specificity Small intestine showed the highest level of expression. Expression in other tissues including gall bladder, liver, testis and stomach is also observed. Along the duodenum- ileum axis, the levels vary in different segments of the intestine with peak expression in the proximal jejunum. Protein expression is confined to the enterocyte. Discrete localization to the epithelial layer bordering the luminal space along the crypt- villus axis. Protein expression in the enterocyte is observed closest to the luminal space. Expression in enterocytes from the proximal (jejunum) but not in the distal (ileum) region

Identical and Related Proteins

Unique RefSeq proteins for LMP013555 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
50300485 RefSeq NP_001002025 1331 Niemann-Pick C1-like protein 1 precursor

Identical Sequences to LMP013555 proteins

Reference Database Accession Length Protein Name
GI:50300485 EMBL CCB07358.1 1331 unnamed protein product [Rattus sp.]
GI:50300485 EMBL CDM55517.1 1331 unnamed protein product [Rattus sp.]
GI:50300485 EMBL CDM63606.1 1331 unnamed protein product [Rattus sp.]
GI:50300485 GenBank AED59492.1 1331 Sequence 2 from patent US 7901893

Related Sequences to LMP013555 proteins

Reference Database Accession Length Protein Name
GI:50300485 EMBL CDM55517.1 1331 unnamed protein product [Rattus sp.]
GI:50300485 EMBL CDM63606.1 1331 unnamed protein product [Rattus sp.]
GI:50300485 GenBank EDM00336.1 1331 NPC1 (Niemann-Pick disease, type C1, gene)-like 1 [Rattus norvegicus]
GI:50300485 SwissProt Q6T3U3.1 1331 RecName: Full=Niemann-Pick C1-like protein 1; Flags: Precursor [Rattus norvegicus]