Gene/Proteome Database (LMPD)
LMPD ID
LMP013561
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase C, zeta 1
Gene Symbol
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; plcz1 {ECO:0000312|RGD:1359567}; phosphoinositide phospholipase C-zeta-1; PLC-zeta-1 {ECO:0000250|UniProtKB:Q86YW0}; phospholipase C-zeta-1 {ECO:0000250|UniProtKB:Q86YW0}; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1;
Chromosome
4
Map Location
4q44
EC Number
3.1.4.11
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | |
|---|---|
| Refseq ID | NP_001012234 |
| Protein GI | 58866040 |
| UniProt ID | Q5FX52 |
| mRNA ID | NM_001012234 |
| Length | 645 |
| MESHYELAEARWFMSKIQDYFRGGKISAGITHKLLEKLDFPCHFAHVKRIFKENDRHNQGRITTEDFRTIYRCIVHREEIVEIFNTYTENRKILPEDSLIEFLTQEQYEMEMDESSSVEIIQKYEPIAEVKNERQMSIEGFARYMFSSECLLFKETCNTVYQDMNKPLNDYYISSSHNTYLISDQILGPSDIWGYISALVKGCRCLEIDCWDGAQNEPIVYHGYTLTSKLLFKTVIQAINKYAFVTSDYPVVLSLENHCSPGQQEVMTDILQSTFGDFLLSDILDEFPDSLPSPEALKFKILVKNKKVGTLSETRERLGTDKRGIALDLEEEIYENEDEDSGKEPETWDDFLSRVKEEQEADPSTLSGIADAKKKIRKLRVALALSDLVIYTKAEKFRNFQYSRVYQQFNETTSMGESRARKLSKLRAHEFIFHTAAFITRVYPKFTRADSSNFNPQEFWNVGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYVLKPDFLRDTTLGFNPNEPEGDGHPVTLTIRLISGIQLPVNVPSNTSDIIVIIEVYGVPNDHMKQQSRAVKNNAFSPRWNETFTFLIQVPELALIRFVVETQGFLSGNELLGQYTLPVLCMNKGYRRVPLFSKSGANLEPSSLFIYVWYYRE | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IEA:InterPro | C | cytosol |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0006816 | IEA:Ensembl | P | calcium ion transport |
| GO:0007343 | IEA:Ensembl | P | egg activation |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0007275 | IEA:UniProtKB-KW | P | multicellular organismal development |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04020 | Calcium signaling pathway |
| rno04020 | Calcium signaling pathway |
| ko00562 | Inositol phosphate metabolism |
| rno00562 | Inositol phosphate metabolism |
| M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
| rno01100 | Metabolic pathways |
| ko04114 | Oocyte meiosis |
| rno04114 | Oocyte meiosis |
| ko04070 | Phosphatidylinositol signaling system |
| rno04070 | Phosphatidylinositol signaling system |
| rno04919 | Thyroid hormone signaling pathway |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028395 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 |
| IPR000008 | C2 domain |
| IPR002048 | EF-hand domain |
| IPR011992 | EF-hand domain pair |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; |
| Domain | The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity |
| Domain | The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q86YW0, ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:18322275, ECO:0000305}. |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 1 EF-hand domain. {ECO:0000255|PROSITE- ProRule:PRU00448}. |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}. |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}. |
| Subcellular Location | Nucleus . Cytoplasm, perinuclear region . Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity) |
| Subunit | Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro |
Identical and Related Proteins
Unique RefSeq proteins for LMP013561 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 58866040 | RefSeq | NP_001012234 | 645 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 |
Identical Sequences to LMP013561 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:58866040 | GenBank | AAW66659.1 | 645 | phospholipase C zeta [Rattus norvegicus] |
| GI:58866040 | GenBank | EDM01563.1 | 645 | phospholipase C, zeta 1 [Rattus norvegicus] |
| GI:58866040 | RefSeq | XP_006237659.1 | 645 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [Rattus norvegicus] |
| GI:58866040 | SwissProt | Q5FX52.1 | 645 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; AltName: Full=Phosphoinositide phospholipase C-zeta-1; AltName: Full=Phospholipase C-zeta-1; Short=PLC-zeta-1 [Rattus norvegicus] |
Related Sequences to LMP013561 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:58866040 | GenBank | AAW66659.1 | 645 | phospholipase C zeta [Rattus norvegicus] |
| GI:58866040 | GenBank | EDM01563.1 | 645 | phospholipase C, zeta 1 [Rattus norvegicus] |
| GI:58866040 | RefSeq | XP_006237659.1 | 645 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [Rattus norvegicus] |
| GI:58866040 | SwissProt | Q5FX52.1 | 645 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; AltName: Full=Phosphoinositide phospholipase C-zeta-1; AltName: Full=Phospholipase C-zeta-1; Short=PLC-zeta-1 [Rattus norvegicus] |