Gene/Proteome Database (LMPD)

LMPD ID
LMP013565
Gene ID
497942
Species
Rattus norvegicus (Rat)
Gene Name
chemokine (C-X-C motif) ligand 16
Gene Symbol
Cxcl16
Alternate Names
C-X-C motif chemokine 16; small-inducible cytokine B16; transmembrane chemokine CXCL16;
Chromosome
10
Map Location
10q24

Proteins

C-X-C motif chemokine 16 precursor
Refseq ID NP_001017478
Protein GI 62945312
UniProt ID Q6AXU5
mRNA ID NM_001017478
Length 247
MRRGFGPLALTLFLFFFALLTLPGDGNQGSVAGSCYCDRTIPSGTQIPPATLNHMRKYLKTFHRCQFFIRFQLQSKSVCGGSQDQWVRELVNCFEHKQCGIGHGQSFHHQKHVPQASTRIPEATEGKPPDTSTAVQFQSTQQSTFPSGAPSLNKELTRHWETTILPSGYGLEARPVAEANEKQHKQQKEPGAGAGTQALVPVLSLLAIVFFLVAAMVCVLCNRRVTRQSSSGLQLCYTPVEPRPQGL
sig_peptide: 1..26 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2871 peptide sequence: MRRGFGPLALTLFLFFFALLTLPGDG mat_peptide: 27..247 product: C-X-C motif chemokine 16 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6AXU5.1) calculated_mol_wt: 24343 peptide sequence: NQGSVAGSCYCDRTIPSGTQIPPATLNHMRKYLKTFHRCQFFIRFQLQSKSVCGGSQDQWVRELVNCFEHKQCGIGHGQSFHHQKHVPQASTRIPEATEGKPPDTSTAVQFQSTQQSTFPSGAPSLNKELTRHWETTILPSGYGLEARPVAEANEKQHKQQKEPGAGAGTQALVPVLSLLAIVFFLVAAMVCVLCNRRVTRQSSSGLQLCYTPVEPRPQGL

Gene Information

Entrez Gene ID
497942
Gene Name
chemokine (C-X-C motif) ligand 16
Gene Symbol
Cxcl16
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IEA:UniProtKB-KW C extracellular space
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005041 IEA:Ensembl F low-density lipoprotein receptor activity
GO:0005044 IEA:Ensembl F scavenger receptor activity
GO:0048247 IEA:InterPro P lymphocyte chemotaxis
GO:0030307 IEA:InterPro P positive regulation of cell growth
GO:0030335 IEA:InterPro P positive regulation of cell migration
GO:0034341 IEA:InterPro P response to interferon-gamma
GO:0034612 IEA:InterPro P response to tumor necrosis factor

KEGG Pathway Links

KEGG Pathway ID Description
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
ko04060 Cytokine-cytokine receptor interaction
rno04060 Cytokine-cytokine receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954120 Chemokine receptors bind chemokines
5954122 Class A/1 (Rhodopsin-like receptors)
5954152 G alpha (i) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954121 Peptide ligand-binding receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR026296 CXC chemokine 16

UniProt Annotations

Entry Information

Gene Name
chemokine (C-X-C motif) ligand 16
Protein Entry
CXL16_RAT
UniProt ID
Q6AXU5
Species
Rat

Comments

Comment Type Description
Function Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity)
Induction By interleukin-18 and the induction is strongly mediated by an activator protein-1-dependent pathway
Ptm Glycosylated
Similarity Belongs to the intercrine alpha (chemokine CxC) family
Subcellular Location Membrane ; Single-pass type I membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013565 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62945312 RefSeq NP_001017478 247 C-X-C motif chemokine 16 precursor

Identical Sequences to LMP013565 proteins

Reference Database Accession Length Protein Name
GI:62945312 GenBank AAY42602.1 247 CXCL16 [Rattus norvegicus]
GI:62945312 GenBank EDM05007.1 247 similar to chemokine (C-X-C motif) ligand 16, isoform CRA_b [Rattus norvegicus]
GI:62945312 GenBank EDM05009.1 247 similar to chemokine (C-X-C motif) ligand 16, isoform CRA_b [Rattus norvegicus]
GI:62945312 SwissProt Q6AXU5.1 247 RecName: Full=C-X-C motif chemokine 16; AltName: Full=Small-inducible cytokine B16; AltName: Full=Transmembrane chemokine CXCL16; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013565 proteins

Reference Database Accession Length Protein Name
GI:62945312 GenBank AAH79312.1 247 Chemokine (C-X-C motif) ligand 16 [Rattus norvegicus]
GI:62945312 GenBank AAY42602.1 247 CXCL16 [Rattus norvegicus]
GI:62945312 GenBank EDM05007.1 247 similar to chemokine (C-X-C motif) ligand 16, isoform CRA_b [Rattus norvegicus]
GI:62945312 GenBank EDM05009.1 247 similar to chemokine (C-X-C motif) ligand 16, isoform CRA_b [Rattus norvegicus]