Gene/Proteome Database (LMPD)
LMPD ID
LMP013586
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
abhydrolase domain containing 12
Gene Symbol
Alternate Names
monoacylglycerol lipase ABHD12; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12;
Chromosome
3
Map Location
3q41
EC Number
3.1.1.23
Proteins
| monoacylglycerol lipase ABHD12 | |
|---|---|
| Refseq ID | NP_001019485 |
| Protein GI | 66730294 |
| UniProt ID | Q6AYT7 |
| mRNA ID | NM_001024314 |
| Length | 398 |
| MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH | |
Gene Information
Entrez Gene ID
Gene Name
abhydrolase domain containing 12
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0032281 | IEA:Ensembl | C | alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex |
| GO:0047372 | IEA:UniProtKB-EC | F | acylglycerol lipase activity |
| GO:0007628 | IEA:Ensembl | P | adult walking behavior |
| GO:0006660 | IEA:Ensembl | P | phosphatidylserine catabolic process |
| GO:0010996 | IEA:Ensembl | P | response to auditory stimulus |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Hydrolyzes glycerol monoesters of long-chain fatty acids. |
| Function | Lysophosphatidylserine (LPS) lipase, that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. Has 2-arachidonoylglycerol (2-AG) hydrolase activity. May act as a regulator of endocannabinoid signaling pathways (By similarity) |
| Ptm | Glycosylated |
| Similarity | Belongs to the serine esterase family |
| Subcellular Location | Membrane ; Single-pass membrane protein . |
Identical and Related Proteins
Unique RefSeq proteins for LMP013586 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 66730294 | RefSeq | NP_001019485 | 398 | monoacylglycerol lipase ABHD12 |
Identical Sequences to LMP013586 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:66730294 | GenBank | AAH78918.1 | 398 | Abhydrolase domain containing 12 [Rattus norvegicus] |
| GI:66730294 | GenBank | EDL86136.1 | 398 | similar to Protein C20orf22 homolog, isoform CRA_d [Rattus norvegicus] |
| GI:66730294 | SwissProt | Q6AYT7.1 | 398 | RecName: Full=Monoacylglycerol lipase ABHD12; AltName: Full=2-arachidonoylglycerol hydrolase; AltName: Full=Abhydrolase domain-containing protein 12 [Rattus norvegicus] |
Related Sequences to LMP013586 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:66730294 | GenBank | AAH78918.1 | 398 | Abhydrolase domain containing 12 [Rattus norvegicus] |
| GI:66730294 | GenBank | EDL28584.1 | 398 | abhydrolase domain containing 12, isoform CRA_a [Mus musculus] |
| GI:66730294 | GenBank | EDL86136.1 | 398 | similar to Protein C20orf22 homolog, isoform CRA_d [Rattus norvegicus] |
| GI:66730294 | SwissProt | Q6AYT7.1 | 398 | RecName: Full=Monoacylglycerol lipase ABHD12; AltName: Full=2-arachidonoylglycerol hydrolase; AltName: Full=Abhydrolase domain-containing protein 12 [Rattus norvegicus] |