Gene/Proteome Database (LMPD)

LMPD ID
LMP013586
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
abhydrolase domain containing 12
Gene Symbol
Alternate Names
monoacylglycerol lipase ABHD12; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12;
Chromosome
3
Map Location
3q41
EC Number
3.1.1.23

Proteins

monoacylglycerol lipase ABHD12
Refseq ID NP_001019485
Protein GI 66730294
UniProt ID Q6AYT7
mRNA ID NM_001024314
Length 398
MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH

Gene Information

Entrez Gene ID
Gene Name
abhydrolase domain containing 12
Gene Symbol
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0032281 IEA:Ensembl C alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0047372 IEA:UniProtKB-EC F acylglycerol lipase activity
GO:0007628 IEA:Ensembl P adult walking behavior
GO:0006660 IEA:Ensembl P phosphatidylserine catabolic process
GO:0010996 IEA:Ensembl P response to auditory stimulus

Domain Information

InterPro Annotations

Accession Description
IPR026605 ABHD12
IPR029058 Alpha/Beta hydrolase fold
IPR029059 Alpha/beta hydrolase fold-5

UniProt Annotations

Entry Information

Gene Name
abhydrolase domain containing 12
Protein Entry
ABD12_RAT
UniProt ID
Species
Rat

Comments

Comment Type Description
Catalytic Activity Hydrolyzes glycerol monoesters of long-chain fatty acids.
Function Lysophosphatidylserine (LPS) lipase, that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. Has 2-arachidonoylglycerol (2-AG) hydrolase activity. May act as a regulator of endocannabinoid signaling pathways (By similarity)
Ptm Glycosylated
Similarity Belongs to the serine esterase family
Subcellular Location Membrane ; Single-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013586 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
66730294 RefSeq NP_001019485 398 monoacylglycerol lipase ABHD12

Identical Sequences to LMP013586 proteins

Reference Database Accession Length Protein Name
GI:66730294 GenBank AAH78918.1 398 Abhydrolase domain containing 12 [Rattus norvegicus]
GI:66730294 GenBank EDL86136.1 398 similar to Protein C20orf22 homolog, isoform CRA_d [Rattus norvegicus]
GI:66730294 SwissProt Q6AYT7.1 398 RecName: Full=Monoacylglycerol lipase ABHD12; AltName: Full=2-arachidonoylglycerol hydrolase; AltName: Full=Abhydrolase domain-containing protein 12 [Rattus norvegicus]

Related Sequences to LMP013586 proteins

Reference Database Accession Length Protein Name
GI:66730294 GenBank AAH78918.1 398 Abhydrolase domain containing 12 [Rattus norvegicus]
GI:66730294 GenBank EDL28584.1 398 abhydrolase domain containing 12, isoform CRA_a [Mus musculus]
GI:66730294 GenBank EDL86136.1 398 similar to Protein C20orf22 homolog, isoform CRA_d [Rattus norvegicus]
GI:66730294 SwissProt Q6AYT7.1 398 RecName: Full=Monoacylglycerol lipase ABHD12; AltName: Full=2-arachidonoylglycerol hydrolase; AltName: Full=Abhydrolase domain-containing protein 12 [Rattus norvegicus]